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  • 1
    Electronic Resource
    Electronic Resource
    Immunological and detoxication interaction in p,p-DDT fed rabbits (1971)
    Springer
    Bulletin of environmental contamination and toxicology 6 (1971), S. 426-435 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Thirty-one rabbits were immunized against Salmonella or SRBC. These rabbits had an impaired immunological response when they received 200 ppm p,p′-DDT in their drinking water during a period of 38 days. The total gamma globulins as reflected by the 7 S fraction were significantly decreased in the p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. This decrease was not statistically significant in the p,p′-DDT-SRBC receiving rabbits when compared with the rabbits receiving only SRBC. The antibody titer against Salmonella was significantly decreased in p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. The decrease of the SRBC antibody titer in the p,p′-DDT-SRBC receiving rabbits was not statistically significant. The plasma total DDT level differed significantly in the two groups receiving p,p′-DDT (p,p′-DDT-Salmonella and p,p′-DDT-SRBC receiving rabbits). This finding may explain the different degree of impairment of the immunological response, the higher plasma DDT level having a more marked effect. These differences in total DDT plasma level in the two groups of rabbits which received the same amount of p,p′-DDT in their drinking water may be considered as a consequence of the concomitant presence of a different kind of foreign antigen in the internal milieu. The bi-directional relationship between a detoxication process and an immunological response is emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684364
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  • 2
    Electronic Resource
    Electronic Resource
    Storage of organochlorine insecticides in adipose tissue of ugandans (1974)
    Springer
    Bulletin of environmental contamination and toxicology 12 (1974), S. 501-508 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary In the framework of a WHO — International Agency Program for Research on Cancer, people from five African, three Asian, and two South American countries were studied for the storage level of organochlorine insecticide storage in the adipose tissue of Ugandans. Specimens of adipose tissue (75) collected during autopsy from Ugandans living in the Kampala area, who had no occupational exposure to organochlorine insecticides were analyzed by the gas chromatographic method for organochlorine insecticides (DDT-derived material, the beta isomer of BHC, dieldrin and heptachlor epoxide). In the 0–4 year age group, DDT-derived material averaged 2.3 ppm; DDT constituted 59.6% of total DDT. In the 5–24 year age group, total DDT averaged 3.84 ppm. DDE constituted 50.2% of total DDT. In the 25–44 year age group, total DDT averaged 2.9 ppm DDE constituted 63.2% of total DDT. In the 45 and over age group, total DDT averaged 2.4 ppm and DDE constituted 53.6% of total DDT. Dieldrin and the beta isomer of BHC were stored at levels below 0.1 ppm and heptachlor epoxide below levels of 0.2 ppm. Males generally stored more OCI than females. Lower storage levels of total DDT were observed in the group aged 45 years and over, when compared to the 5–24 and 25–44 year age groups. In comparison to other populations in Africa, Asia, and South America, people from Uganda stored the lowest amount of OCI. It is proposed that the 25–44 year age group may characterise the OCI storage level of a community since in this age group DDT-derived material tends to be stored at higher concentrations in the adipose tissue of people in several countries, when compared to lower age groups. (In the over 45 year age groups the level of DDT-derived material varies from country to country being higher or lower than in the 25–44 year age group.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684989
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of organochlorine compounds on serum proteins (1973)
    Springer
    Bulletin of environmental contamination and toxicology 10 (1973), S. 42-50 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Many OCC are at present current constituents of the global ecosystem. Their biological effects are of great interest to ecologists and environmental toxicologists. This paper deals with the interrelationship between OCC (p,p′-DDT, Dieldrin and Arochlor 1221) and the serum level of protein fractions in rabbits receiving the above-mentioned compounds. Sixty rabbits were divided into 6 groups given respectively no OCC, 200 ppm p,p′-DDT, 50 ppm Dieldrin, 200 ppm Arochlor-1221, 100 ppm p,p′-DDT and 100 ppm Arochlor-1221, 25 ppm Dieldrin and 100 ppm Arochlor in their drinking water which contained 6‰ ethyl alcohol in all groups. After p,p′-DDT administration the increased plasma levels of DDT were accompanied by increased levels of Dieldrin,γ-BHC and PCBs, although the animals did not receive extra dosage of these OCC, except the amounts currently present in food and water. Dieldrin administration led to a concomitant increase in total DDT plasma level. A moderate increase in total DDT plasma level occurred also after the administration of PCBs. When administered concomitantly, in half doses, the same results were obtained at a lower level. Variations in plasma level of different OCC as a result of feeding a given compound may explain differences in the degree of toxicity based on the resultant of metabolic interrelationships of OCC in the animal body. The serum level of gamma globulin fractions (IgG and IgM) shows a tendency to decrease in rabbits given OCC. The serum albumin level rose in rabbits receiving OCI and fell in those receiving PCBs. In regard to the biological effects of OCC these facts point to a moderation of the activity of the immunological system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684753
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of adrenalectomy on the storage of organochlorine insecticides (1971)
    Springer
    Bulletin of environmental contamination and toxicology 5 (1971), S. 373-378 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539953
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of organochlorine insecticides on serum cholesterol level in people occupationally exposed (1971)
    Springer
    Bulletin of environmental contamination and toxicology 5 (1971), S. 368-372 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary Serum cholesterol was determined in 206 workers occupationally exposed to organochlorine insecticides (OCI) and in 86 workers non-occupationally exposed to these chemicals. In both groups of workers the serum cholesterol level increased with age. The increase was greater in exposed workers but the difference between the two groups was statistically significant only in the over 45 years age group. It is thought that OCI induce an increase of cholesterol synthesis, but this process is masked by a concomitant breakdown. In the over 45 years age group a diminished reactivity of homeostatic processes may explain the finding of enhanced cholesterol synthesis which is no longer masked by concomitant catabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539952
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of organochlorine insecticides on serum PBI level in occupationally exposed people (1971)
    Springer
    Bulletin of environmental contamination and toxicology 6 (1971), S. 85-88 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Conclusions This paper reports on the level of serum PBI in a group of 42 workers handling OCI as compared to a control group of 51 workers not occupationally exposed to these insecticides. Practically all the serum PBI values were within the range considered as normal. However, the serum PBI was significantly lower in workers occupationally exposed to OCI when compared to the non-occupationally exposed workers (p〈0.01). It is suggested that the presence of OCI in the human body affects the metabolism of thyroxine. Homeostasis is maintained by a sustained effort of the hypophyso-thyroid system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01559078
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of dieldrin and gamma BHC on serum proteins and PBI (1972)
    Springer
    Bulletin of environmental contamination and toxicology 8 (1972), S. 177-185 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684474
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  • 8
    Electronic Resource
    Electronic Resource
    The fine structure of adrenal zona glomerulosa in the adult rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 235-243 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal zona glomerulosa ; Rat ; Normal ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This paper reports on an electron microscopic study of the adrenal zona glomerulosa in the normal rat, with special emphasis on the structural diversity of mitochondria in its parenchymatous cells. The mitochondria of cristae may be tubulo-vesicular, plate-like and/or straight tubular, any one mitochondrion containing one or more types of cristae. The mitochondrial features of the zona glomerulosa parenchymatous cells are attributed to the biochemical stages of aldosterone synthesis, taking place in different mitochondria of these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222276
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  • 9
    Electronic Resource
    Electronic Resource
    Quantitative determination of effective dipole and monopole moments of magnetic force microscopy tips (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 3410-3417 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present experimental results on the characterization of commercially available magnetic force microscopy (MFM) thin film tips as a function of an external magnetic field. Well defined magnetic stray fields are produced using current carrying rings with radii ranging between 603 and 2369 nm fabricated by electron-beam lithography directly imaged by MFM. Treating the MFM tip as a point probe, the analysis of the image contrast as a function of both the magnetic stray field and the lift height allows for a quantitative determination of effective magnetic dipole and monopole moments of the tip as well as their imaginary location within the real physical tip. Our systematic study gives a quantitative relationship on how absolute values of the magnetic dipole and monopole moments and their location within the tip depend on a characteristic decay length of the z component of the magnetic field being detected. From this we can estimate the effective tip volume of the real physical thin film tip relevant in MFM imaging. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371222
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  • 10
    Electronic Resource
    Electronic Resource
    Ease of wound closure as an endpoint of treatment efficacy (1999)
    Oxford, UK : Blackwell Science Inc
    Wound repair and regeneration 7 (1999), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: New treatments for chronic wounds require carefully performed clinical trials with significant endpoints. Total wound closure is the only endpoint currently accepted by the Food and Drug Administration. This study describes a scale that measures ease of wound closure and applies it to a four-arm prospectively randomized, blinded pressure ulcer trial of recombinant human platelet-derived growth factor-BB. Following validation of interrater reliability, 83 evaluable subjects' photographs were given a weekly ease of closure score by four raters blinded to treatment. The change of ease of closure score was correlated with the change of wound area and volume. Each ease of closure score was given a procedural cost. Results showed ease of closure did not directly correlate with either wound area or volume, suggesting that it was measuring additional information. The mean change in ease of closure score was 6 for subjects treated with 100 μg recombinant human platelet-derived growth factor-BB daily; 5 for those treated with 300 μg growth factor daily or 100 μg recombinant human platelet-derived growth factor-BB bid; and 4 for those treated with placebo. The cost savings ranged from $7200 for the group receiving 100 μg recombinant human platelet-derived growth factor-BB daily to $6300 for the controls. Outcomes in all 4 groups were significantly improved from their starting evaluation (p 〈 0.001). Based on this study, ease of closure is a verifiable endpoint that can be related to cost efficiency and may be a measure of efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-475X.1999.00090.x
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