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  • 1995-1999  (3)
  • 1970-1974
  • litter clearance and accumulation  (2)
  • Gamma-amino  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Baclofen, a gamma-aminobutyric acid-b receptor agonist, delays diabetes onset in the non-obese diabetic mouse (1995)
    Springer
    Acta diabetologica 32 (1995), S. 53-56 
    Details
    ISSN: 1432-5233
    Keywords: Non-obese diabetic mouse ; Gamma-amino ; butyric acid ; Glutamic acid decarboxylase ; Baclofen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glutamic acid decarboxylase (GAD) is the enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA). GAD has been identified as a 64-kDa antigen expressed in pancreatic beta-cells, to which autoantibodies are generated prior to the onset of type 1 (insulin-dependent) diabetes mellitus. GAD may therefore be an initiating factor in beta-cell destruction. We administered baclofen, a GABA-B receptor agonist, to non-obese diabetic (NOD) mice in an attempt to down-regulate GAD expression and thereby reduce the incidence of diabetes. Twenty-four female NOD mice were given baclofen in their drinking water at a final dose of 50 mg/kg body weight daily from weaning to 30 weeks of age. Twentyfour sex-and litter-matched mice were used as controls. At 30 weeks there was no difference in the incidence of diabetes in the treated group compared with the controls. However, there was a significant delay in the onset of diabetes in the treated group (P〈0.001, parallelism test). The degree of insulitis and the GAD activity in the pancreas per mg of protein were unchanged by baclofen treatment with respect to controls. These results suggest that baclofen may be effective in delaying diabetes onset in NOD mice by stimulating GABA activity, as this neurotransmitter, localised in the islets, may modulate insulin secretion and the antigen expression associated with it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581047
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    MOVEMENT PATTERNS OF RIVERINE LITTER (1997)
    Springer
    Water, air & soil pollution 98 (1997), S. 119-139 
    Details
    ISSN: 1573-2932
    Keywords: litter clearance and accumulation ; riverine litter ; time of travel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Aspects of litter movement were looked at in a variety of ways. River bank clearances provided valuable information on litter accumulation and movement, showing a distinctive correlation between flood events and litter movement. Introduction of litter outside of channel deposition (diffuse sources) were limited in the study area in South Wales, UK. A rise in litter deposition occurred for some time after flood events, with the main accumulation occurring in the mid-bank zone. As only some litter types have an increased input during flood events e.g. sewage-derived material from combined sewer outfalls (CSO), accumulation of other litter types, e.g. plastic sheeting could be due to their distribution throughout the catchment. A positive correlation between litter stranding and vegetation was found. During high flows, (75.59 cumecs) litter is removed from sites with little restraining vegetation and deposited where stranding potential is high. Smaller items such as feminine hygiene products were more susceptible to stranding than larger plastic sheeting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026424715108
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Movement patterns of riverine litter (1997)
    Springer
    Water, air & soil pollution 98 (1997), S. 119-139 
    Details
    ISSN: 1573-2932
    Keywords: litter clearance and accumulation ; riverine litter ; time of travel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Aspects of litter movement were looked at in a variety of ways. River bank clearances provided valuable information on litter accumulation and movement, showing a distinctive correlation between flood events and litter movement. Introduction of litter outside of channel deposition (diffuse sources) were limited in the study area in South Wales, UK. A rise in litter deposition occurred for some time after flood events, with the main accumulation occurring in the mid-bank zone. As only some litter types have an increased input during flood events e.g. sewage-derived material from combined sewer outfalls (CSO), accumulation of other litter types, e.g. plastic sheeting could be due to their distribution throughout the catchment. A positive correlation between litter stranding and vegetation was found. During high flows, (75.59 cumecs) litter is removed from sites with little restraining vegetation and deposited where stranding potential is high. Smaller items such as feminine hygiene products were more susceptible to stranding than larger plastic sheeting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02128653
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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