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  • 1995-1999  (4)
  • 1970-1974
  • Kramer-Mesner method  (2)
  • Transcranial magnetic stimulation  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 107 (1996), S. 479-485 
    ISSN: 1432-1106
    Keywords: Transcranial magnetic stimulation ; Learning and memory ; Cortical physiology ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the role of the dorsolateral prefrontal cortex in procedural learning. Normal subjects completed several blocks of a serial reaction time task using only one hand without or with concurrent non-invasive repetitive transcranial magnetic stimulation. To disrupt their function transiently, stimulation was applied at low intensity over the supplementary motor area or over the dorsolateral prefrontal cortex contralateral or ipsilateral to the hand used for the test. Stimulation to the contralateral dorsolateral prefrontal cortex markedly impaired procedural implicit learning, as documented by the lack of significant change in response times during the task. Stimulation over the other areas did not interfere with learning. These results support the notion of a critical role of contralateral dorsolateral prefrontal structures in learning of motor sequences.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Motor cortex ; Exercise ; Transcranial magnetic stimulation ; Inhibition ; Paired stimuli ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transcranial magnetic stimulation (TMS) causes the corticospinal system to become refractory to subsequent stimuli for up to 200 ms. We examined the phenomenon of paired pulse inhibition with TMS under conditions of rest, ongoing voluntary activation (isometric force generation), and at variable delays following activation (postactivation) of the wrist extensors of seven normal subjects. Paired stimuli were delivered to the motor cortex with a circular coil at 1.1 times motor evoked potential (MEP) threshold, with various interstimulus intervals. Voluntary activation caused a marked decrease in the variability of the ratio of the amplitude of the MEP evoked by the test pulse to that of the MEP evoked by the conditioning pulse. Marked inhibition of the MEP evoked by the test pulse was still present. Postactivation, however, caused a dramatic reversal of the inhibitory effect of the conditioning pulse in all subjects at interstimulus intervals ranging from 40 to 120 ms. This effect lasted for up to 10 s following the cessation of activation. MEPs to transcranial electrical stimulation were also inhibited by conditioning TMS, but postactivation did not reverse this inhibition, indicating that the reversal of paired pulse inhibition is intracortical. We conjecture that paired pulse inhibition reflects activity of inhibitory interneurons or inhibitory connections between cortical output cells that are inactivated in the postactivation state.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Designs, codes and cryptography 15 (1998), S. 5-27 
    ISSN: 1573-7586
    Keywords: t-design ; Kramer-Mesner method ; intersection number ; isomorphism problem ; group action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract We show the existence of simple 8-(31,10,93) and 8-(31,10,100) designs. For each value of λ we show 3 designs in full detail. The designs are constructed with a prescribed group of automorphisms PSL(3,5) using the method of Kramer and Mesner KramerMesner76. They are the first 8-designs with small parameters which are known explicitly. We do not yet know if PSL(3,5) is the full group of automorphisms of the given designs. There are altogether 138 designs with λ = 93 and 1658 designs with λ = 100 and PSL(3,5) as a group of automorphisms. We prove that they are all pairwise non-isomorphic. For this purpose, a brief account on the intersection numbers of these designs is given. The proof is done in two different ways. At first, a quite general group theoretic observation shows that there are no isomorphisms. In a second approach we use the block intersection types as invariants, they classify the designs completely.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Designs, codes and cryptography 17 (1999), S. 181-186 
    ISSN: 1573-7586
    Keywords: t-design ; Steiner system ; Kramer-Mesner method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Up to now, all known Steiner 5-designs are on q + 1 points where q ≡ 3 (mod 4) is a prime power and the design is admitting PSL(2, q) as a group of automorphisms. In this article we present a 5-(36,6,1) design admitting PGL(2, 17) × C 2 as a group of automorphisms. The design is unique with this automorphism group and even for the commutator group PSL(2, 17) × Id 2 of this automorphism group there exists no further design with these parameters. We present the incidence matrix of t-orbits and block orbits.
    Type of Medium: Electronic Resource
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