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  • 1
    ISSN: 1434-5196
    Keywords: Key words Internal cerebral vein thrombosis ; Sinovenous thrombosis ; Colitis ulcerosa ; Trauma ; Schlüsselwörter Hirnvenenthrombose ; Sinusthrombose ; Trauma ; Colitis ulcerosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Venöse Abflußstörungen des Gehirns werden mit unterschiedlicher Häufigkeit im Obduktionsgut aufgeführt. Neben entzündlichen Prozessen, hämorheologischen Störungen und Neoplasien kommen bei der forensischen Begutachtung traumatische Ursachen für die Genese von Thrombosen in Frage. Berichtet wird über eine 14 Jahre alt gewordene Schülerin, die 2 1/2 Tage nach einer tätlichen Auseinandersetzung verstarb. Anamnestisch wurde von einer Colitis ulcerosa berichtet. Initial waren weder äußere Verletzungen noch neurologische Auffälligkeiten erkennbar. In der Nacht wurde sie komatös in der Klinik aufgenommen. Die kranielle computertomographische Untersuchung zeigte eine zunehmende intraventrikuläre und intrazerebrale Blutung, Zeichen der venösen Stauung und ein Hirnödem. Die Patientin verstarb im dissoziierten Hirntod. Neuropathologisch fand sich eine in Organisation stehende Thrombose des Sinus sagittalis superior, die sich in die inneren Hirnvenen fortsetzte und die durch die entzündliche Darmerkrankung verursacht war. Eine traumatische Genese war somit auszuschließen.
    Notes: Abstract Thromboses of the cerebral veins which occur at a frequency of 3.75 to 9.3% in autopsy material are caused by local or systemic inflammatory processes, hematological disorders, neoplasms or traumatic brain damage. We report on a 14-year-old girl who suffered from colitis ulcerosa during the last 4 years of life. Immediately after a brawl with a schoolboy she complained of headache and vertigo, but no physical abnormality was detected by the physician. She was admitted to the hospital after becoming comatose during the following night. On neurological examination she was comatous with a decerebrate state, the pupils were small and non-reactive to light, divergent ocular bulbi and bilateral extensor plantar responses. A cerebral computer tomogramm showed a cerebral edema and a hemorrhage in the left basal ganglia and both cerebral ventricles which subsequently increased to the right cerebral ganglia, the corpus callosum and the right cerebral hemisphere. Despite antiedematous therapy the girl died on the second day after the brawl. A neuropathology examination revealed thrombosis of the superior sagittal sinus extending to the internal cerebral veins and a bilateral hemorrhagic infarction of the thalamus and the basal ganglia with intraventricular hemorrhage. As the thrombus in the sagittal sinus showed signs of organisation, a postraumatic origin alone is improbable and a hemorrheological disorder due to colitis ulcerosa seemed to be the main cause.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Key words Isotopic analysis ; Overall fractionation factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In this study we investigated the contribution of diffusion limitation to the exercise-induced hypoxaemia in interstitial lung disease (ILD). We applied isotopic analysis to the composition of the stable isotopic oxygen molecules 16O2 and 16O18O in expiratory gas mixtures obtained from six ILD patients and six healthy subjects at rest and during ergometer work (60 W). The changes in the 16O18O/16O2 ratios were interpreted by using the overall fractionation factor of respiration (α O) which would be increased towards 1.03 on increasing diffusion limitation. In addition, the O2 partial pressures of alveolar gas and arterial blood (P AO2, P aO2) were determined. In the patients, α O was significantly reduced from 1.0066 ± 0.0004 (mean ± SD) at rest to 1.0035 ± 0.0004 during exercise and in the healthy subjects from 1.0072 ± 0.0008 to 1.0044 ± 0.0004. Furthermore, the exercise-induced reduction of P aO2 (from 77 to 69 mmHg) was due to a drop of alveolar PO2 found in each patient, whereas in each healthy subject P aO2 was increased on exercise. On the basis of a resistance model we conclude that the patients’ data were inconsistent with increasing diffusion limitation but showed an increasing impairment of O2 transport by ventilation.
    Type of Medium: Electronic Resource
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