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  • 1
    Electronic Resource
    Electronic Resource
    CHEMICAL ROUTES TO COENZYME B12 AND ANALOGUES (1964)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 112 (1964), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1964.tb45032.x
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  • 2
    Electronic Resource
    Electronic Resource
    Partial Synthesis of Vitamin B 12 Coenzyme and Analogues (1962)
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 1175-1175 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The reaction product from fully reduced hydroxocobalamin and 5'-tosyl-2',3'-isopropylideneadenosine was purified via phenol extraction and passage of an aqueous solution through columns of DEAE-cellulose and CM-cellulose in series. The product passed rapidly through the former and more slowly ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1941175a0
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  • 3
    Electronic Resource
    Electronic Resource
    Sulphitocobalamin (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 170-171 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Preliminary experiments directed towards the synthesis of the vitamin B12 coenzyme1 consisted of a re-investigation of the action of certain sulphur-containing reducing agents on hydroxocobalamin following the report of Pawelkiewicz2, who claimed a synthesis of the coenzyme form of Factor B by the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/199170b0
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  • 4
    Electronic Resource
    Electronic Resource
    The Stainable Mucin of Joint Tissues and Synovial Fluid (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 835-836 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present work, specimens of synovial membrane were removed immediately after death from the parapatellar region of the knee-joint of 5 rats, 10 guinea pigs, 10 rabbits, 10 cats, 5 dogs, 5 sheep and 4 monkeys, and from 4 human subjects at postmortem. In addition, specimens of articular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/190835a0
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  • 5
    Electronic Resource
    Electronic Resource
    Biotin production under limiting growth conditions by Agrobacterium/Rhizobium HK4 transformed with a modified Escherichia coli bio operon (1999)
    Springer
    Journal of industrial microbiology and biotechnology 22 (1999), S. 590-599 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: biotin production; E. coli bio operon; Agrobacterium/Rhizobium HK4; limiting growth conditions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: E. coli biotin (bio) operon was modified to improve biotin production by host cells: (a) the divergently transcribed wild-type bio operon was re-organized into one transcriptional unit; (b) the wild-type bio promoter was replaced with a strong artificial (tac) promoter; (c) a potential stem loop structure between bioD and bioA was removed; and (d) the wild-type bioB ribosomal binding site (RBS) was replaced with an artificial RBS that resulted in improved bioB expression. The effects of the modifications on the bio operon were studied in E. coli by measuring biotin and dethiobiotin production, and bio gene expression with mini-cells and two-dimensional polyacrylamide gel electrophoresis. The modified E. coli bio operon was introduced into a broad host-range plasmid and used to transform Agrobacterium/Rhizobium HK4, which then produced 110 mg L−1 of biotin in a 2-L fermenter, growing on a defined medium with diaminononanoic acid as the starting material. Biotin production was not growth-phase dependent in this strain, and the rate of production remained high under limiting (maintenance) and zero growth conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900669
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  • 6
    Electronic Resource
    Electronic Resource
    The Diffusion of Bromine into CdTe (1995)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 182-184 (Feb. 1995), p. 57-62 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.182-184.57.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Inhaled nitric oxide does not increase lipid peroxidation in preterm infants (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 1033-1033 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050994
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  • 8
    Electronic Resource
    Electronic Resource
    Conjunctival impression cytology in the preterm infant and it's relation to outcome (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 471-475 
    Details
    ISSN: 1432-1076
    Keywords: Key words Conjunctival cytology  ;  Newborn Retinol status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The preterm infant is deficient in vitamin A (retinol) and this has been implicated in the pathogenesis of chronic lung disease of prematurity. Conjunctival impression cytology (CIC) has been used in adults to assess retinol status. We aimed to assess the feasibility of performing CIC in the preterm infant and to determine the significance of abnormal CIC findings. CIC samples were collected during routine retinopathy screening, and classified as inadequate, normal, borderline normal or abnormal. Ninety preterm infants were studied. Seventy-four (82%) CIC specimens produced a positive yield, whereas 16 (18%) were inadequate. Of the 74 adequate samples, 61 (82%) were normal or borderline normal and 13 (18%) abnormal. Seventy-three CIC specimens were assessed by a second histopathologist with complete agreement on 64 (88%) samples and disagreement on 9 (12%) samples. Ten sets of conjunctival impressions, taken from both eyes, gave identical results in all adequate samples. Birth weight was significantly lower in this abnormal group. Four infants (32%) in the abnormal group required treatment for retinopathy compared to two (3%) in the normal/borderline normal group. (P 〈 0.01) Conclusion Conjunctival impression cytology is simple and reproducible technique which maybe easily applied to the preterm infant. Abnormal CIC is associated with retinopathy of prematurity requiring treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050642
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  • 9
    Electronic Resource
    Electronic Resource
    Outcome predictors in pregnant opiate and polydrug users (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 748-749 
    Details
    ISSN: 1432-1076
    Keywords: Key words Opiate ; Drugs ; Pregnancy ; Neonatal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A retrospective case note study of 93 women was performed in order to assess the effect of maternal factors on neonatal outcome in a group of women attending a specialist clinic for pregnant drug users. There were no significant differences in outcome for chaotic drug users compared with non-chaotic drug users, or for cocaine users compared with non-cocaine using drug users. Women who reduced their methadone dose during pregnancy delivered babies of significantly higher birth weight than those whose methadone dose remained the same or increased (median 3027 g, range 1780–3629 g vs 2645 g, range 580–3720 g). Women who abused benzodiazepines during pregnancy produced babies of significantly lower birth weight than those women who did not use benzodiazepines (median 2100 g, range 580–3520 g vs 2767 g, range 1530–3720 g). Conclusion The results of this study give healthcare staff evidence to use in encouraging drug-using women to avoid benzodiazepines during pregnancy and to reduce their methadone dosage. The treatment received from a specialist clinic may mitigate against some of the other recognised effects of drug use during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051193
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  • 10
    Electronic Resource
    Electronic Resource
    The use of pulse oximetry in the prevention of hyperoxaemia in preterm infants (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 222-224 
    Details
    ISSN: 1432-1076
    Keywords: Key words Oximetry ; Hyperoxaemia ; Preterm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When deciding an appropriate upper limit for pulse oxygen saturation (SpO2) in preterm infants the usefuleness of current data is limited by the fact that previous studies have examined a population of more mature infants and children or have applied various exclusion criteria which produce results unrepresentative of clinical practice. We tested the hypothesis of previous workers that maintaining the SpO2 below 98% would ensure an arterial oxygen tension (PaO2) less than 12 kPa. A total of 477 simultaneous measurements of PaO2 and SpO2 were made using Ohmeda Biox oximeters on 43 infants who were less than 33 weeks gestation and receiving supplementary oxygen. Of 435 measurements performed when the SpO2 was 97% or less, 26 (6%) had a PaO2 greater than 12 kPa. Further examination of the data showed that of 108 estimations performed when the SpO2 was less than 94%, none had a PaO2 greater than 12 kPa. Conclusion When using Ohmeda Biox pulse oximeters an upper limit of 97% for SaO2 is not effective in preventing hyperoxaemia; however, a limit of 93% is likely to maintain the PaO2 below 12 kPa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954276
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