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  • 1995-1999  (2)
  • 1940-1944
  • Diels-Alder reactions  (1)
  • Graft-versus-host disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    [a]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 97-102 
    Details
    ISSN: 1434-4475
    Keywords: 3-Vinylindoles ; Carbazoles ; Diels-Alder reactions ; Cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die aus den methoxysubstituierten 3-Vinylindolen1 und2 zugänglichen Cycloaddukte3,5 und7 lassen sich mitDDQ zu den coplanar-anellierten Carbazolen4,6 und8 dehydrieren. Verbindung4a, die auch durch eine Röntǵenstrukturanalyse charakterisiert wurde, zeigt signifikante Cytotoxizität gegen Humantumor-Zellinien (K562 und RXF93).
    Notes: Summary The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807414
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  • 2
    Electronic Resource
    Electronic Resource
    Graft-versus-host disease following second syngeneic stem cell transplantation for relapsed chronic myeloid leukemia (1998)
    Springer
    Annals of hematology 77 (1998), S. 283-286 
    Details
    ISSN: 1432-0584
    Keywords: Key words Chronic myeloid leukemia ; Graft-versus-host disease ; Transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Allogeneic bone marrow transplantation is the only curative treatment for patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML); however, recurrence of disease remains a major cause of treatment failure. A 26-year-old man with chronic myeloid leukemia who had a cytogenetic relapse 49 months after his first syngeneic bone marrow transplant (BMT) and hematologic relapse 23 months thereafter progressed to blast crisis despite treatment with IFN-alpha for 15 months. He underwent a second transplantation in early second blast crisis, 92 months after the first BMT with PBPC from his previous donor. Successful hematological reconstitution occurred. On day 50 after the second transplantation the patient developed a generalized rash, hepatomegaly, and cholestatic signs. Skin and liver biopsy revealed changes compatible with acute graft-versus-host disease (GVHD). Treatment with cyclosporin A (CSA) and prednisone was started, and the GVHD resolved. Fifteen months after PBPC transplantation he had a molecular relapse. Despite discontinuation of CSA, the patient progressed into blast crisis 7 months later. The occurrence of GVHD and disappearance of the BCR-ABL-positive clone suggest that a graft-versus-leukemia (GVL) effect may have been operative for 15 months in a patient given a second syngeneic BMT in blast crisis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050459
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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