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  • 1
    Electronic Resource
    Electronic Resource
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a total of 77 patients with epithelial ovarian carcinomas, new biologic parameters [estrogen and progesterone receptor (ER, PR), DNA-ploidy (DP), S-phase fraction (Spf), cycling index (Ki67), Her2b/neu oncoprotein, epidermal growth factor receptor (EGF-R), cathepsin D and P170 glycoprotein] have been simultaneously detected and correlated to the clinical outcome [progression-free (PFI) and overall survival (OAS)] in a preliminary study. Apart from conventional prognosticators (age, stage, grade, residual tumor) and the postoperative serum marker Ca125, DP (P = 0.01), Spf (P = 0.009), Ki67 (P = 0.05) and PR (P = 0.01) could predict a short OAS (log rank test), whereas cathepsin D was of borderline significance only. Prognostic significance could be improved by using combinations of different factors [two markers of differentiation (DP, PR), one marker of proliferation (Spf) and one marker describing local tumor spread (cathepsin D)]. The difference in prognosis between patients with either all or three favorable tumor factors and patients with two to four unfavorable tumor factors reached a similar significance as can be obtained using FIGO stage as a prognostic factor (P = 0.007 for PFI, P = 0.0005 for OAS). These results were similar if early stages (FIGO I and II) were excluded. However, in a Cox regression analysis, including stage and residual tumor, this combination was significantly independent for PFI and OAS and could give additional information. Therefore, the large number of new biologic tumor markers could be restricted to only a few significant prognosticators to predict prognosis in primary epithelial ovarian carcinoma. In the future tumor characterizations may allow more individualized treatment with more aggressive, or even without, cytotoxic therapy after primary surgery.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The q-profile measurement presented in this article is based on the observation of pellets injected into the plasma and viewed with a fast-framing camera. The pellets sublimate in the plasma and the ablated material is ionized. The ions move along the magnetic field lines, while an ablation cloud is forming. This ablation cloud contains a small fraction of neutral particles which emit visible light after collisional excitation. It is therefore possible to visualize the magnetic field lines along which the pellet passes. The inclination angle of the magnetic field lines with respect to the torus midplane can be determined from this observation. The results are compared with the inclination angles delivered by an equilibrium code. Further analysis shows that it is not meaningful to determine the q-profile from the data of only the pellet ablation, in the case of an elongated plasma as in ASDEX Upgrade. However, the accuracy of the q-profile determined by an equilibrium code, especially in the plasma center, can be greatly improved by using the pellet measurements as additional input data. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During normoventilation and‘light’, haemodynamically stable, steady-state anaesthesia with isoflurane 0.3%, the effect of ketamine intravenously was investigated in 24 patients randomly assigned to one of the following groups: group 1 (control group) no ketamine, group 2 (ketamine group) ketamine 2mg.kg, group 3 (ketamine/midazolam group) ketamine 2mg.kg-1 after pretreatment with midazolam and group 4 (ketamine/esmolol group) ketamine 2mg.kg -1 while maintaining mean arterial blood pressure at a preketamine level with esmolol. Ketamine-induced cerebrovascular changes were measured by means of transcranial Doppler ultrasonography. Control readings in patients without ketamine challenge demonstrated stable cardiovascular and cerebrovascular baseline conditions. Cerebral blood flow velocity and mean arterial blood pressure, however, significantly increased after administration of ketamine without pretreatment. The increase in cerebral blood flow velocity could not be blocked by maintaining mean arterial blood pressure at baseline value with esmolol. In contrast, the effects of ketamine on cerebral blood flow velocity and mean arterial blood pressure were prevented by prior administration of midazolam. The results suggest that ketamine may significantly influence intracerebral haemodynamics via a direct drug effect rather than via a secondary effect due to changes in arterial carbon dioxide and/or mean arterial blood pressure.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 4 (1998), S. 959-963 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Seit unserer ersten Übersicht der Therapiestudien beim Mammakarzinom in Deutschland (s. Heft 3/1995) konnten ein Teil der Studien erfolgreich abgeschlossen werden, einige mußten aufgrund schlechter Rekrutierung abgebrochen werden und ein großer Teil, insbesondere die adjuvanten Therapiestu- dien der German Adjuvant Breast Cancer Group (GABG), sind weiterhin aktiv und aktuell. In diesem Update soll vor allem auf neue, in der Zwischenzeit initiierte Studien eingegangen werden. Wie vorher kann jedoch kein Anspruch auf Vollständigkeit gegeben werden, da die Zahl größerer und kleinerer Untersuchungen unermeßlich ist.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 3 (1997), S. 364-368 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Als besondere Lokalisation der primären Manifestation sind die axillären Lymphknoten anzusehen. Hier ist die zugrundeliegende Erkrankung meist gut behandelbar und die Prognose ist günstiger als bei UPC (unknown primary carcinoma) mit anderer Lokalisation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Im europäischen Raum hat sich für die Rekonstruktion der Vagina weitgehend die Technik nach Vecchietti durchgesetzt. Der Nachteil des klassischen Verfahrens, die dazu notwendige Laparotomie, kann durch die neue mikroinvasive Präparationstechniken ersetzt und ausgeglichen werden. Die dargestellte endoskopische Technik der Scheidenrekonstruktion stellt eine wichtige Erweiterung des operativen Spektrums dar. Sie führt gegenüber der klassischen Methode nach Vecchietti zu keiner erhöhten Komplikationsrate. Sie erfüllt alle Vorteile, die an eine gute Technik zur Vaginalrekonstruktion gestellt werden. Sie ermöglicht funktionell hervorragende Resultate, vermeidet Probleme im Entnahmebereich, wie sie bei Darmtransplantaten und Hauttransplantaten auftreten und ist eine atraumatische operative Technik ohne die Notwendigkeit einer Laparotomie.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-0879
    Keywords: Bladder cancer ; Urothelium ; CD44V2 ; Alternative splicing ; Immunohistochemistry ; Diagnostic marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD44 is the principal cell surface receptor for hyaluronate. Variant forms of the receptor, produced by alternative splicing, have been found to be associated with tumor progression in a variety of cancers. Based on investigations at the RNA level, it has recently been proposed that expression of CD44 variant V2 was present in urothelial cancer but not in normal urothelium. Since a distinctive marker for urothelial cancer would be extremely useful, frozen sections of normal urothelium and urothelial cancer were examined for expression of standard CD44 and CD44V2. Frozen sections of specimens of 35 patients with transitional cell carcinoma of the bladder, 16 specimens of normal bladder and 5 ureters were examined. Immunohistochemical staining was performed using a polyclonal antibody to CD44V2 (PAB CD44V2), a monoclonal antibody to CD44V2 (MAB CD44V2) and a monoclonal antibody to CD44S (MAB CD44S). CD44V2 and CD44S were also measured in lysates of urine sediments from 21 patients by enzyme-linked immunoabsorbent assay (ELISA). All investigated transitional cell carcinomas expressed CD44V2. There was no differentiation between invasive and noninvasive carcinoma. CD44V2 was also expressed in normal urothelium. Standard CD44 was expressed by the transitional cell carcinoma, normal urothelium, musculature and interstitial tissue. The amount of CD44V2 and CD44S in lysates of urine sediments is not correlated to diagnosis. In contrast to investigations at the RNA level, CD44V2 on the protein level seems not to be a distinctive marker for urothelial cancer. Therefore, CD44V2 will not be a useful diagnostic marker for detection of transitional cell carcinoma.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Electrical engineering 14 (1925), S. 448-464 
    ISSN: 1432-0487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Zusammenfassung Die folgenden Ausführungen bilden einen Auszug aus der gleichnamigen Schrift, welche als Dissertation bei der Eidgenössischen Technischen Hochschule, Zürich, eingereicht wurde. In diesem Auszuge ist von mathematischen Ableitungen so weit als möglich abgesehen, und nur das für die Anwendung der Theorie Wichtige wiedergegeben, in der Meinung, dafэ im vorliegenden Falle weniger die theoretischen Untersuchungen, als die praktischen Anwendungen von allgemeinem Interesse sind. Die Anregung zu den Untersuchungen über die Analogien der elektrischen und der elastischen Systeme ergab sich aus der Schrift von Dr. Fr. Natalis: Die Berechnung von Gleich- und Wechselstromsystemen. In dieser Schrift sind auch die Grundlagen der im folgenden verwerteten Rechnungsverfahren gegeben.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 18 (1997), S. 417-444 
    ISSN: 1432-0541
    Keywords: Key words. Parallel computation, Algorithms, Packet routing, Meshes, Buses, Lower bounds, Randomization, Coloring.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. We consider the problem of routing packets on an $n\times\cdots\times n$ MIMD mesh-connected array of processors augmented with row and column buses. We give lower bounds and randomized algorithms for the problem of routing k-permutations (where each processor is the source and destination of exactly k packets) on a d-dimensional mesh with buses, which we call the (k,d)-routing problem. We give a general class of ``hard'' permutations which we use to prove lower bounds for the (k,d)-routing problem, for all k,d≥ 1. For the (1,1)- and (1,2)-routing problems the worst-case permutations from this class are identical to ones published by other authors, as are the resulting lower bounds. However, we further show that the (1,d)-routing problem requires 0.72 ... n steps for d=3, 0.76 ... n steps for d=4, and slightly more than $(1-1/d)\cdot n$ steps for all d≥ 5. We also obtain new lower bounds for the (k,d)-routing problem for k,d 〉 1, which improve on the bisection lower bound in some cases. These lower bounds hold for off-line routing as well. We develop efficient algorithms for the (k,1)-routing problem and for the problem of routing k-randomizations (where each processor has k packets initially and each packet is routed to a random destination) on the one-dimensional mesh and use them in a general (k,d)-routing algorithm which improves considerably on previous results. In particular, the routing time for the (1,d)-routing problem is bounded by $(2-1/d) \cdot n + o(n)$ steps with high probability (whp), whenever $d\leq n^{1/2-\epsilon}$ for some constant ε 〉 0, and the routing time for the (k,d)-routing problem is $k\cdot n/3+o(k\cdot n)$ steps whp whenever $d=(k\cdot n)^{1/2-\epsilon}$ for some constant ε 〉 0 and k≥ 3.6 ... d, matching the bisection lower bound. We then present a simple algorithm for the (2,2)-routing problem running in 1.39 ... n+o(n) steps whp. Finally, for the important special case of routing permutations on two-dimensional meshes with buses, the (1,2)-routing problem, we give a more sophisticated algorithm that runs in 0.78 ... n+o(n) steps whp.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 19 (1997), S. 427-446 
    ISSN: 1432-0541
    Keywords: Key words. Graph algorithms, Triangulation, Planarity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. Triangulation of planar graphs under constraints is a fundamental problem in the representation of objects. Related keywords are graph augmentation from the field of graph algorithms and mesh generation from the field of computational geometry. We consider the triangulation problem for planar graphs under the constraint to satisfy 4-connectivity. A 4-connected planar graph has no separating triangles, i.e., cycles of length 3 which are not a face. We show that triangulating embedded planar graphs without introducing new separating triangles can be solved in linear time and space. If the initial graph had no separating triangle, the resulting triangulation is 4-connected. If the planar graph is not embedded, then deciding whether there exists an embedding with at most k separating triangles is NP-complete. For biconnected graphs a linear-time approximation which produces an embedding with at most twice the optimal number is presented. With this algorithm we can check in linear time whether a biconnected planar graph can be made 4-connected while maintaining planarity. Several related remarks and results are included.
    Type of Medium: Electronic Resource
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