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  • 1
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Elektronenstrahl CT ; Koronarkalzifikationen ; Koronargefäßscreening ; Key words Electron beam CT ; Coronary calcification ; Coronary screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: To compare electron beam CT (EBCT) und prospectively ECG gated conventional CT for the detection and quantification of coronary artery calcifications. Methods: 42 patients (mean age 62.8±8.8 years) were scanned, both with EBCT and ECG gated sequential CT. For quantification, the traditional „total calcium score” (TCS) according to the Agatson method as well as the ”volumetric calcium score” (VCS) as determined with a stand-alone workstation (NetraMD) was calculated for both modalities. Results: There was close correlation between EBCT and conventional CT, both for TCS (r=0.984) as well as for VCS (r=0.986) score values. The median difference was 17% for TCS and 13% for VCS. The difference between the two modalities was not statistically significant (p=0.44). Conclusion: EBCT and prospectively ECG triggered conventional CT are equivalent for the quantification of coronary artery calcifications. The extent of calcifications can be established with both modalities using either TCS or VCS score values.
    Notes: Zusammenfassung Fragestellung: Zwei alternative Methoden zur Quantifizierung von Koronarkalzifikationen bei einer vergleichenden Untersuchung mit einem Elektronenstrahl-CT (EBCT) und einem konventionellen CT mit prospektiver EKG-Triggerung (SEQ) sollten untersucht werden. Methodik: 42 Patienten (62,8±8,8 Jahre) wurden sowohl mit dem EBCT als auch mit dem SEQ untersucht. Zur Quantifizierung wurde bei beiden Modalitäten der „Traditional Calcium Score” (TCS) nach Agatston als auch der „Calcium Volumetric Score” (CVS) mit einer externen Workstation (NetraMD) ermittelt. Ergebnisse: Es zeigte sich sowohl für den TCS (r=0,984) als auch für den CVS (r=0,986) eine sehr gute Korrelation der Scorewerte zwischen EBCT und SEQ. Der Median der prozentualen Differenz lag für TCS bei 17% und für CVS bei 13%. Der Unterschied zwischen den beiden Scoringverfahren war statistisch nicht signifikant (p=0,44). Schlußfolgerung: EBCT und SEQ liefern vergleichbare Daten zur Quantifizierung von Koronarkalzifikationen. Das Ausmaß der Verkalkungen kann mit beiden Modalitäten sowohl mit dem TCS als auch mit dem CVS gleichermaßen festgestellt werden.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Key words Schizophrenia ; Hippocampus ; Ibotenic acid ; Social behaviour ; Anxiety ; Animal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Rationale: Neonatal ibotenic acid lesion of the ventral hippocampus was proposed as a relevant animal model of schizophrenia reflecting positive as well as negative symptoms of this disease. Before and after reaching maturity, specific alterations in the animals’ social behaviour were found. Objective: In this study, social behaviour of ventral hippocampal lesioned rats was analysed. For comparison, rats lesioned either in the ventral hippocampus or the dorsal hippocampus at the age of 8 weeks were tested. Methods: Rats on day 7 of age were lesioned with ibotenic acid in the ventral hippocampus and social behaviour was tested at the age of 13 weeks. For comparison, adult 8-week-old rats were lesioned either in the ventral or the dorsal hippocampus. Their social behaviour was tested at the age of 18 weeks. Results: It was found that neonatal lesion resulted in significantly decreased time spent in social interaction and an enhanced level of aggressive behaviour. This shift is not due to anxiety because we could not find differences between control rats and lesioned rats in the elevated plus-maze. Lesion in the ventral and dorsal hippocampus, respectively, in 8-week-old rats did not affect social behaviour. Conclusions: The results of our study indicate that ibotenic acid-induced hippocampal damage per se is not related to the shift in social behaviour. We favour the hypothesis that these changes are due to lesion-induced impairments in neurodevelopmental processes at an early stage of ontogenesis.
    Type of Medium: Electronic Resource
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