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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis of the first Japanese patient with 3-oxo-δ 4-steroid 5β-reductase deficiency by use of immunoblot analysis (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 386-390 
    Details
    ISSN: 1432-1076
    Keywords: Key words 3-Oxo-Δ4-steroid 5β-reductase deficiency ; 3-oxo-Δ4 bile acid ; Immunoblot analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 3-oxo-Δ4-steroid 5β-reductase (5β-reductase) deficiency is difficult to diagnose because severe liver damage can result in a similar pattern of metabolite excretion. We investigated the usefulness of immunoblot analysis for diagnosis of 5β-reductase deficiency and quantitatively analysed urinary bile acids by gas chromatography-mass spectrometry in a 5-month-old Japanese boy with severe neonatal cholestasis associated with hypertyrosinaemia. A liver sample was examined by immunoblot analysis using monoclonal antibodies against 5β-reductase. Urinary 3-oxo-Δ4 bile acids accounted for 88.3% of total bile acids, 5α-bile acids for 0.9%, and primary bile acids for 9.1%. Immunoblot analysis of the liver tissue showed an indistinct band of 5β-reductase. Conclusions These findings suggest that this patient had a secondary 5β-reductase deficiency due to severe liver damage, even though 3-oxo-Δ4 bile acids constituted more than 70% of total urinary bile acids. However, the patient may possibly have had an inherited 5β-reductase deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050835
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term increases in neuronal activity in the motor cortex evoked by simultaneous stimulation of the thalamus and somatosensory cortex in cats (1999)
    Springer
    Neuroscience and behavioral physiology 29 (1999), S. 475-481 
    Details
    ISSN: 1573-899X
    Keywords: Long-term potentiation ; motor cortex ; somatosensory cortex (SCx) ; thalamus ; ventrolateral nucleus (VL) ; cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Experiments on anesthetized cats were used to study the activity of motor cortex neurons (field 4γ) in response to separate and simultaneous stimulation of the ventrolateral nucleus of the thalamus and the somatosensory cortex (field 2) of the brain. Long-term potentiation of motor cortex neuron activity in response to simultaneous stimulation of the ventrolateral nucleus and somatosensory cortex arose only in regions receiving corticocortical projections from the stimulation site in the somatosensory cortex of the brain, while regions lacking corticocortical projections from the somatosensory cortex showed no such effect. Experiments demonstrated that the duration of increased motor cortex neuron activity following stimulation of the ventrolateral nucleus of the thalamus and somatosensory cortex was greater than one hour after recording was started. These data led to the conclusion that simultaneous stimulation of corticocortical and thalamocortical afferents can alter the level of neuronal activity in the motor cortex only in regions with convergent sensory inputs from the thalamus and somatosensory cortex of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02461088
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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