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  • 1995-1999  (2)
  • 5-Hydroxytryptamine 2A receptor antagonist  (1)
  • Anaerobic treatment  (1)
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  • 1995-1999  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    γ-Mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist (1997)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1997), S. 25-31 
    Details
    ISSN: 1432-1912
    Keywords: Key wordsγ-Mangostin ; 5-Hydroxytryptamine ; 5-Hydroxytryptamine 2A receptor antagonist ; Rabbit aorta ; Rat coronary ; Rabbit platelet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract γ-Mangostin, purified from the fruit hull of the medicinal plant Garcinia mangostana caused a parallel rightwards shift of the concentration/response curve for the contraction elicited by 5-hydroxytryptamine (5-HT) in the rabbit aorta (pA2 = 8.2) without affecting the contractile responses to KCl, phenylephrine (α1) or histamine (H1). The perfusion pressure response of rat coronary artery to 5-HT (5-HT2A) was reduced concentration dependently by γ-mangostin (IC50 = 0.32 μM). 5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by γ-mangostin (IC50 = 0.29 μM), whereas that induced by thrombin was not affected, nor did γ-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists. Furthermore, 5-HT-induced contraction of the rat fundus (5-HT2B) and 5-HT-induced relaxation of the rabbit aorta in the presence of ketanserin (5-HT1) and carbachol-induced contraction of the guinea-pig ileum (muscarinic M3) were not affected by γ-mangostin (5 μM). γ-Mangostin inhibited [3H]spiperone binding to cultured rat aortic myocytes (IC50 = 3.5 nM). The K d for [3H]spiperone binding was increased by γ-mangostin (3 nM) from 11.7 to 27.4 nM without affecting B max. These results suggest that γ-mangostin is a novel competitive antagonist, free from a nitrogen atom, for the 5-HT2A receptors in vascular smooth muscles and platelets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005134
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Methanogenic granular sludge formation in an upflow anaerobic sludge blanket reactir treating synthetic methanolic waste (1995)
    Springer
    World journal of microbiology and biotechnology 11 (1995), S. 631-637 
    Details
    ISSN: 1573-0972
    Keywords: Anaerobic treatment ; granular sludge characteristics ; granulation ; methanolic waste ; UASB reactor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A laboratory upflow anaerobic sludge blanket reactor, seeded with fine, suspended, bacterial floc with 1.76 g volatile suspended solids/l, was used to treat synthetic methanolic waste. After 180 days of continuous peration, granular sludge with discrete granules of 1 to 2 mm diam. was formed, with 52 g volatile suspended solids/l. Granules were brown, relatively soft and had a settling velocity of 1.61 cm/s. Extracellular polymeric matter extracted from the granular sludge had high carbohydrate content but low nucleic acid content. The ash of the granular sludge contained Na+, K+ and Mg2+ up to 15.0, 11.7 and 3.75 mg/g, respectively. Scanning and transmission electron microscopy revealed that the granular sludge was dominated by methanogens resembling Methanosarcina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361005
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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