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  • 1
    Electronic Resource
    Electronic Resource
    A phase II study of cisplatin, oral administration of etoposide, OK-432 and radiation therapy for inoperable stage III non-small cell lung cancer (1998)
    Springer
    International journal of clinical oncology 3 (1998), S. 365-369 
    Details
    ISSN: 1437-7772
    Keywords: Stage III non-small cell lung cancer ; CDDP ; VP-16 ; Conventional radiotherapy ; Concurrent chemoand radiotherapy ; Accelerated proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. This study was designed to evaluate the feasibility and efficiency of giving cisplatin, etoposide, and OK432 concurrently with conventional radiotherapy (RTx) for patient's with inoperable stage III, based on the TNM classification according to the International Union against Cancer staging system for lung cancer (1987) non-small cell lung cancer (NSCLC). Methods. From January 1992 to December 1994,31 patients with cytologically or histologically confirmed stage III NSCLC were treated with RTx, to a total dose of 56–64 Gy, with concurrent daily oral administration of etoposide (25mg) and cisplatin (20mg) for 5 days during the third or fourth week from the start of RTx. The subcutaneous injection of 1 or 2 KE of OK-432, three times a week, for the duration of radiotherapy also started from the beginning of RTx. Results. The number of eligible patients was 29 (26 men and 3 women). Their mean age was 66 years (range, 55–77 years). Six patients had an Eastern Cooperative Oncology Group performance status (PS) of 0; 15, 1; 8; 2. Three were stage IIIA, and 26, stage ITIB. Histologically, 2 had adenocarcinoma, 23, squamous cell carcinoma, and 4, large cell carcinoma. In 27 of the 29 patients, the RTx schedule was completed. There were no treatment-related deaths. Grade 4 toxicity (according to World Health Organisation criteria) leukopenia (700/μl was observed in 1 patient. The response rate was 79% and the median survival was 17 months. Survival rates at 1, 2 and 3 years were 62%, 31%, and 21%, respectively. The local failure rate was 51%. Conclusion. The combination of cisplatin, etoposide, and K-432, given concurrently with conventional RTx is feasible and effective for inoperable stage III NSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539214
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  • 2
    Electronic Resource
    Electronic Resource
    A low-Na+ diet enhances expression of mRNA for epithelial Na+ channel in rat renal inner medulla (1997)
    Springer
    Pflügers Archiv 434 (1997), S. 756-763 
    Details
    ISSN: 1432-2013
    Keywords: Key words Inner medulla ; Inner medullary collecting duct ; Low-Na+ diet ; mRNA expression ; Polymerase chain reaction ; Reverse transcriptase ; Rat epithelial Na+ channel ; rENaC ; Na+ transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The purpose of the present study was to determine whether the renal inner medulla expresses mRNA for the rat epithelial Na+ channel (rENaC) and, if so, to define its regulatory properties using a low-Na+ diet model. We detected α, β and γ subunit mRNA in rat renal inner medulla using reverse transcriptase-polymerase chain reaction (RT-PCR) with primers specific for rENaC α, β and γ subunits. Moreover, we have developed a specific probe for the α subunit using RT-PCR with rENaC α-subunit-specific primers. The resulting cDNA was verified by sequencing and was then used in Northern blot analysis of distal colon, whole kidney and inner medulla. The probe for the rENaC α subunit hybridized not only to distal colon RNA but also to inner medulla RNA derived from rats fed a normal diet. Furthermore, we examined the effect of a low-Na+ diet on α, β and γ subunit mRNA expression of rENaC using full-length cDNA as a probe. A marked elevation of rENaC α subunit mRNA abundance in the inner medulla was observed in response to a high plasma aldosterone concentration induced by dietary Na+ deprivation. On the other hand, neither β nor γ subunit mRNA expression was enhanced by a low-Na+ diet. From these results, it is suggested that rENaC is responsible for Na+ transport in the renal inner medulla and that is probably regulated via transcriptional control of the α subunit of ENaC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050462
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    Paper (German National Licenses)
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