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Plasmid RNA polymerase-like mitochondrial sequences inAgaricus bitorquis (1996)

Robison, Mary M. ; Horgen, Paul A.

Springer

Current genetics 29 (1996), S. 370-376

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ISSN: 1432-0983

Keywords: Plasmid ; RNA polymerase ; Mitochondrion ; Agaricus

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract A linear mitochondrial plasmid, pEM, found in certain isolates of the basidiomyceteAgaricus bitorquis potentially encodes virus-like DNA and RNA polymerases. Mitochondrial DNA fromAgaricus bisporus that hybridizes to an internal region of pEM contains a fragmented and potentially non-functional version of the carboxy terminal end of the plasmid RNA polymerase. In this study, we present the sequence of the corresponding region of mitochondrial DNA fromA. bitorquis. This sequence contained the same region of the plasmid RNA polymerase gene as was reported for the mitochondrial DNA ofA. bisporus, and the level of similarity between theA. bisporus andA. bitorquis mitochondrial sequences was much higher than the level of similarity between either mitochondrial sequence and the plasmid. We propose that this plasmid RNA polymerase-like sequence was present in theAgaricus mitochondrial genome before the divergence ofA. bisporus andA. bitorquis, and thus is unlikely to be a recent derivative of the plasmid pEM.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02208618

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New strategies for treating AIDS (1996)

Sandstrom, Paul A. ; Folks, Thomas M.

New York, NY : Wiley-Blackwell

BioEssays 18 (1996), S. 343-346

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ISSN: 0265-9247

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for anti-retroviral drugs(1). The second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection(2).

Additional Material: 2 Ill.