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  • 1995-1999  (2)
  • Alternating high magnetic fields  (1)
  • Schizophrenia  (1)
  • reproduction  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Biological responses inCaenorhabditis elegans to high magnetic fields (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 284-288 
    Details
    ISSN: 1420-9071
    Keywords: Alternating high magnetic fields ; eddy current ; magnetic flux concentration ; Caenorhabditis elegans ; growth ; reproduction ; behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Here we describe a device for testing possible influences of high magnetic fields on biological processes, by which alternating-current magnetic stimuli as high as 1.7 T can be administered. Experiments with a simple multicellular organism, the nematodeCaenorhabditis elegans, revealed that intermittent exposure to the magnetic fields modestly inhibited the animal's reproduction as well as its post-embryonic development, and caused a marked but transient derangement in its locomotory behavior. Available evidence indicates that alternating high magnetic fields can elicit both chronic and acute biological effects, but that the effects may be well tolerated or compensated for by the living organism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01931113
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Novel variants in the promoter region of the CREB gene in schizophrenic patients (1999)
    Springer
    Journal of human genetics 44 (1999), S. 428-430 
    Details
    ISSN: 1435-232X
    Keywords: Key words cAMP-responsive element-binding protein ; Transcription factor ; Promoter ; Variant ; Schizophrenia ; Clinical characteristics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used by most dopamine and serotonin receptor subtypes. In addition, CREB stimulates the expression of a number of genes, alterations in the expression of which may be associated with schizophrenia. The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia. Eighty unrelated schizophrenics and 100 healthy controls were screened for genetic variants of the CREB gene by SSCP analysis, followed by direct sequencing of PCR products. Two novel variants (−933T?C and −413G?A) were found only in schizophrenics. A patient with the −933T?C variant had unusual clinical characteristics in addition to typical schizophrenic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050196
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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