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Intestinal mucosal lipid peroxidation and absorptive function In Salmonella typhimurium mediated intestinal infection (1998)

Mehta, Alka ; Singh, Surjit ; Dhawan, Veena ; [et al.]

Springer

Molecular and cellular biochemistry 178 (1998), S. 345-352

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ISSN: 1573-4919

Keywords: Salmonella typhimurium ; brush border membrane ; lipid peroxidation ; free radicals ; antioxidants

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract S. typhimurium infection is associated with neutrophil infiltration within the intestinal mucosa. Neutrophil activation provides a major source of reactive oxygen species (ROS). The mucosal pathology of S. typhimurium infection may be in part due to the excessive production of these reactive species. This study was carried out to investigate if ROS play a role in mediating the changes in the structural components and functional properties of brush border membrane (BBM) in rats during S. typhimurium infection. This was done by determining the changes in the BBM extent of lipid peroxidation and absorptive function. A significant increase in the extent of lipid peroxidation of BBM during S. typhimurium infection was observed as judged by malondialdehyde (MDA) and conjugated diene formation and depletion of α-tocopherol and protein associated thiol groups. A significant decrease in the BBMV (brush border membrane vesicle) transport of amino acids was also observed. However there was no change in the transport of D-glucose. The decrease in amino acid transport further led to a significant decrease in the enterocyte level of protein synthesis. Exposure of BBMV to a free radical donor, cumene hydroperoxide, also led to an increase in the extent of lipid peroxidation and a decrease in the amino acid transport. Possibly ROS might play a significant role in mediating the mucosal damage during S. typhimurium infection.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006891019115

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Ab initio molecular orbital calculations on the associated complexes of lithium cyanide with ammonia (1995)

Mohandas, P. ; Shivaglal, M. C. ; Chandrasekhar, J. ; [et al.]

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 55 (1995), S. 477-484

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ISSN: 0020-7608

Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Ab initio molecular orbital (MO) calculations with the 3-21G and 6-31G basis sets are carried out on a series of complexes of NH3 with Li+, C≡N-, LiCN, and its isomer LiNC. The BSSE-corrected interaction energies, geometrical parameters, internal force constants, and harmonic vibrational frequencies are evaluated for 15 species. Complexes with trifurcated (C3v) structures are calculated to be saddle points on the potential energy surfaces and have one imaginary frequency each. Calculated energies, geometrical parameters, internal force constants, and harmonic vibrational frequencies of the various species considered are discussed in terms of the nature of association of LiCN with ammonia. The vibrational frequencies of the relevant complexed species are compared with the experimental frequencies reported earlier for solutions of lithium cyanide in liquid ammonia. © 1995 John Wiley & Sons, Inc.

Additional Material: 1 Ill.