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  • 1
    Electronic Resource
    Electronic Resource
    Macrophage inflammatory protein-1 alpha expression in non-neoplastic and neoplastic lung tissue (1996)
    Springer
    Virchows Archiv 428 (1996), S. 107-111 
    Details
    ISSN: 1432-2307
    Keywords: Macrophage inflammatory protein-1 alpha ; Monoclonal antibody ; Alveolar type II cell ; Fibroblast ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The chemokines are members of a bipartite superfamily of soluble proteins that have been implicated in a wide range of acute and chronic inflammatory processes, as well as other immunoregulatory functions. Macrophage inflammatory protein-1 alpha (MIP-1α) belongs to the C-C subfamily of these chemokines and is primarily a potent chemoattractant and activator of monocytes. MIP-1α is also thought to play a role in host defence. We examined the expression of MIP-1α in normal lung, inflammatory lung tissue and lung cancer cells by the immunoperoxidase method using a MIP-1α monoclonal antibody. MIP-1α protein was found to be expressed not only by alveolar macrophages, but also by bronchial ciliated cells, hyperplastic alveolar type II cells and activated fibroblasts surrounding malignant tissue. Of 33 cases of lung cancer, 23 (70%) expressed MIP-1α. These observations suggest that lung cancer cells, non-neoplastic alveolar type II cells and fibroblasts can participate in inflammatory cell recruitment via the production of MIP-1α. Tumour derived MIP-α may also affect the interaction between lung cancer and host inflammatory cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193938
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic analysis of disease resistance to all strains of BaYMV in a Chinese barley landrace, Mokusekko 3 (1997)
    Springer
    Theoretical and applied genetics 94 (1997), S. 871-877 
    Details
    ISSN: 1432-2242
    Keywords: Key words Hordeum vulgare L. ; Barley yellow mosaic virus (BaYMV) ; Disease resistance ; Linkage ; Esterase isozyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A Chinese landrace of barley, Mokusekko 3, is unique in being completely resistant against all strains of barley yellow mosaic virus (BaYMV). The present investigation revealed that the resistance of Mokusekko 3 is governed by two recessive genes. As one of the resistance genes was known to be tightly linked with alleles at the Est complex locus, consisting of the Est1, Est2 and Est4 loci for esterase isozymes, each of the resistance genes could be separated by means of marker-assisted selection using an isozyme allelic combination as a marker. One of the resistance genes, ym1, is linked to K (hooded lemma) and gl3 (glossy leaf 3) with recombination values of 25.3% and 9.7% respectively, and these three genes are located in the order K-gl3-ym1 on chromosome 4. Another newly designated resistance gene, ym5, is linked to alleles at the Est complex locus and cu2 (curly growth 2), with recombination values of 1.9% and 19.5% respectively, in the order cu2-Est-ym5 from proximal to distal on the long arm of chromosome 3. The complete resistance of Mokusekko 3 is caused by combining two resistance genes, ym1 and ym5. However, almost all the “resistant” cultivars derived from crosses with Mokusekko 3 are susceptible to the recently detected strain BaYMV-III in Japan, since they contain only one resistance gene, ym5. Marker-assisted selection to combine resistance genes into a cultivar is discussed for the breeding of stabilizing resistance to BaYMV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050489
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    Paper (German National Licenses)
    Fulltext
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