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  • 1
    Electronic Resource
    Electronic Resource
    Effects of a small dose of triazolam on P300 and resting EEG (1996)
    Springer
    Psychopharmacology 125 (1996), S. 179-184 
    Details
    ISSN: 1432-2072
    Keywords: EEG ; ERP ; P300 ; Benzodiazepine ; Hypnotics ; Cognition ; Sleepiness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to clarify whether cognitive impairments caused by benzodiazepines (BDZs) are a consequence of their specific direct effects on cognitive function or whether they are explained as secondary effects of increased sleepiness. Ten healthy men (mean age, 33.9 years) participated in two experimental sessions in a randomized cross-over, double-blind study: in one session subjects were given a placebo and in the other they were given 0.125 mg triazolam (TRZ). Each experimental session was conducted on 1 day. After a pre-drug EEG recording and an event-related potential (ERP) recording, under an oddball paradigm, subjects took the TRZ or placebo orally at 1000 hours. Thereafter, EEG and ERP recording sessions, following the same procedure as the pre-drug sessions, were conducted at 1, 2, 4, 6 and 8 h after drug administration. The EEG and ERP recordings from Cz and Pz referred to the bilaterally linked ear electrodes were used. We found that P300 latency was significantly prolonged in TRZ condition at 2 h (Pz) and 4 h (Cz and Pz) after TRZ, and that the P300 amplitude was significantly reduced at 2 h (Cz and Pz) and 4 h (Pz) after TRZ, compared to the same times after placebo. The absolute power values for the theta (4–7 Hz), alpha 1 (8–9 Hz), and alpha 2 (10–12 Hz) bands did not differ at any measurement time between the treatments. Only the beta band (13–19 Hz) power value was significantly elevated after the TRZ administration (versus placebo). No significant sedative effects were detected in subjective measurements. These results indicate that a single oral dose of 0.125 mg TRZ caused cortical changes without distinct general sedation or subjective sleepiness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249418
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  • 2
    Electronic Resource
    Electronic Resource
    CMV protecton in transgenic cucumber plants with an introduced CMV-O cp gene (1996)
    Springer
    Theoretical and applied genetics 93 (1996), S. 672-678 
    Details
    ISSN: 1432-2242
    Keywords: CMV-cp gene ; Transgenic cucumber plants ; CMV resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We introduced the CMV-O coat-protein gene into cucumber plants, using a Ti-Agrobacterium-mediated transformation system, with the aim of producing cucumber plants with CMV resistance. The RNA transcripts from the CaMV 35s-cp gene could be detected in the leaves of the R0 transgenic cucumber plants, as well as in the epicotyls containing two cotyledons of transgenic progeny plants, by Northern-blot analysis; but the presence of coat protein originating from the CaMV 35s-cp gene could not be detected in the cotyledons or leaves of R0 and transgenic progeny plants by Westernblot analysis. The progenies of a cross between cv “Sharp 1” and transgenic plants (pure line “1021”) possessing the cp gene displayed strong resistance to inoculation of the CMV-Y strain, although both the control cv “Sharp 1” and segregated cp - plants displayed many spotted disease symptons on their leaves 5–6 days after CMV-Y inoculation on the cotyledons. The control “1021” had a slight tolerance toward CMV-Y inoculation. The transgenic cucumber plants displayed the absence of resistance to ZYMV. However, transgenic plants showed a reduced degree of disease symptom development following a double inoculation of CMV and ZYMV. The CMV resistance of the present transgenic cucumber plants seems to be due to the synergism of the slight CMV tolerance in the pure line “1021” and the protection against CMV afforded by the introduction of the CMV cp gene. This leads to the possibility of producing cucumber plants with the agronomic characteristics of very strong CMV resistance by the combination of genotypes of cucumbers and the CMV cp gene. The transgenic plants possessing the cp gene should thus be useful as a genetic source for producing cucumber plants with the agronomic characteristic of CMV resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224061
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    Paper (German National Licenses)
    Fulltext
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