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  • 1995-1999  (10)
  • Visual evoked potentials  (3)
  • temperature  (3)
  • Cardiomyoplasty  (2)
  • INFLAMMATORY BOWEL DISEASE  (2)
  • 1
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Optic neuritis ; Multiple sclerosis ; Visual evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MRI of the optic nerves was obtained in 13 patients with acute optic neuritis and 13 with a previous optic neuritis (ON), assessed by clinical features, visual fields and visual evoked potentials. Results of the conventional short tau inversion recovery (STIR) sequence obtained with a short echo time (STE-STIR; 22 ms) were compared with those of a long echo time (LTE-STIR: 80 ms) sequence. The conventional STE-STIR sequence revealed lesions in the optic nerves in 78.5 % of acute and 58.8 % of previous ON. The LTE-STIR sequence showed abnormalities in 92.8 % of acutely symptomatic nerves and 94.1 % of nerves with previous ON. The optic nerve lesions appeared significantly longer with the LTE-STIR sequence than with the conventional STE-STIR sequences, in both acute and previous ON.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Optic neuritis ; Multiple sclerosis ; Visual evoked potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MRI of the optic nerves was obtained in 13 patients with acute optic neuritis and 13 with a previous optic neuritis (ON), assessed by clinical features, visual fields and visual evoked potentials. Results of the conventional short tau inversion recovery (STIR) sequence obtained with a short echo time (STE-STIR; 22 ms) were compared with those of a long echo time (LTE-STIR: 80 ms) sequence. The conventional STE-STIR sequence revealed lesions in the optic nerves in 78.5% of acute and 58.8% of previous ON. The LTE-STIR sequence showed abnormalities in 92.8% of acutely symptomatic nerves and 94.1% of nerves with previous ON. The optic nerve lesions appeared significantly longer with the LTE-STIR sequence than with the conventional STE-STIR sequences, in both acute and previous ON.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Hydrobiologia 400 (1999), S. 129-140 
    ISSN: 1573-5117
    Keywords: fish ; energetics ; temperature ; feeding ; prey abundance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract I examined food consumption and growth of walleye larvae in extensive culture ponds using direct methods and a bioenergetics model, and compared my results with laboratory feeding and growth studies. Walleye showed a diel pattern of increasing gut fullness during daylight hours. Larvae exhibited lower maximum food consumption rates in the ponds than predicted from previous short-term laboratory feeding studies. Direct estimates and bioenergetics model estimates of daily food consumption in the culture ponds were in poor agreement and the discrepancy varied with respect to walleye size. Food consumption rates in the ponds were related to walleye size (direct estimates) or water temperature (bioenergetics model estimates) but not zooplankton abundance. Growth exceeded 0.10 g g−1 d−1 for all but one sampling interval and the maximum growth rate in the culture pond fish was double the maximum growth rate determined in the laboratory. Growth was positively related to pond temperature and negatively related to walleye mass, but was not significantly related to zooplankton abundance. Gross conversion efficiency was negatively related to walleye mass, positively related to zooplankton abundance and not related to temperature. Food consumption and growth of walleye larvae in the field may be food-limited at much lower prey abundances than previous laboratory research has suggested.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2614
    Keywords: heparin ; anticoagulation ; cardiopulmonary bypass ; temperature ; normothermia ; hypothermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Notes: Abstract Objective. With the practice of warm cardiopulmonary bypass (CPB) at our institution we have observed an apparent increase in heparin requirements. CPB temperature predictability affects pharmacokinetics and differences in drug metabolism can be expected. We hypothesized that heparin requirements would increase with increasing CPB temperature. Methods. Following Institutional Review Board approval, we reviewed the charts of 354 patients undergoing primary coronary artery bypass graft surgery. We recorded patient demographic data, CPB duration, heparin requirements, and temperature during CPB. CPB was conducted between 24 °C and 37 °C. The Spearman's correlation coefficient, Pearson chi-square, and rank-sum tests were used for data analysis. Results. Core temperature during CPB correlated with heparin requirements (r = 0.13, p 〈 0.02). However, CPB duration was shorter in warm patients than in cold patients (r = −0.455, p 〈 0.0001). Additional heparin requirements adjusted for duration of CPB (units/minute) were also significantly greater in the warm group (p = 0.018). Conclusions. Maintenance of adequate heparin anticoagulation during CPB is clinically important. Warm CPB patients required more heparin per minute than those undergoing cold CPB. More frequent assessment of anticoagulation and administration of additional heparin should be considered in patients undergoing warm CPB.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-2568
    Keywords: INFLAMMATORY BOWEL DISEASE ; THROMBOPHILIA ; COAGULATION ; ACTIVATED PROTEIN C ; RESISTANCE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thromboembolic events frequently complicate theclinical course of patients with inflammatory boweldisease (IBD). Hereditary thrombophilia may contributeto this tendency. Resistance to activated protein C is the most recently described thrombophilicstate and may account for up to 40% of patients withthrombophilia. Thirty-seven patients with IBD werestudied (mean age 44 years, range 18-82 years). Three patients had a history of thrombotic episodes.The 37 controls included 23 men and 17 women (mean age48 years, range 16-89 years). Disease activity wasassessed using the Harvey Bradshaw index for patients with Crohn's disease and the Truelove and Wittsgrading system for patients with ulcerative colitis.Levels of fibrinogen, antithrombin III (ATIII), proteinC, protein S, activated protein C resistance (APCR), and the presence of a lupusanticoagulant (LA) were determined. Median ATIII levelsin patients with IBD were significantly lower thancontrols (98% vs 106%, P = 0.007), while fibrinogen waselevated (4.2 vs 3.3 g/liter, P = 0.026) despitequiescent disease activity. LA was detected in 7/37patients in the IBD group compared to 0/37 controls.(χ2 = 5.68, P = 0.017). No significantdifference was observed in levels of inherited thrombophilic factorsand in particular APCR between IBD patients andcontrols. In conclusion, the presence of inheritedthrombophilic defects, in particular APCR, is uncommonin patients with IBD and does not merit routinescreening.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2568
    Keywords: INFLAMMATORY BOWEL DISEASE ; ANTI-CARDIOLIPIN ANTIBODIES ; DEEP VENOUS THROMBOSIS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Elevated levels of anti-cardiolipin antibodiesare associated with an increased risk for venous andarterial thrombosis. In patients with inflammatory boweldisease thrombosis is a well known complication. We determined the prevalence of elevatedanti-cardiolipin antibodies in 136 patients withinflammatory bowel disease compared with 136 healthycontrols and analyzed thromboembolic complications inpatients with increased anti-cardiolipin antibodylevels. Anti-cardiolipin antibody titers weresignificantly elevated in patients with Crohn's disease(5.7 units/ml) and ulcerative colitis (5.3 units/ml)compared to the control group (2.5 units/ml). We foundno correlation between disease activity andanti-cardiolipin antibody levels. Seven patients haddeep venous thrombosis in their history, in three ofthem this was complicated by pulmonary embolism. In onlytwo of the seven patients with deep venous thrombosiswere anti-cardiolipin antibody levels increased. Inconclusion, anti-cardiolipin antibody titers were significantly increased in patients withinflammatory bowel disease. Elevated anti-cardiolipinantibody levels appear to play no role in thepathogenesis of thromboembolic events in patients withinflammatory bowel disease.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Hydrobiologia 400 (1999), S. 129-140 
    ISSN: 1573-5117
    Keywords: fish ; energetics ; temperature ; feeding ; prey abundance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract I examined food consumption and growth of walleye larvae in extensive culture ponds using direct methods and a bioenergetics model, and compared my results with laboratory feeding and growth studies. Walleye showed a diel pattern of increasing gut fullness during daylight hours. Larvae exhibited lower maximum food consumption rates in the ponds than predicted from previous short-term laboratory feeding studies. Direct estimates and bioenergetics model estimates of daily food consumption in the culture ponds were in poor agreement and the discrepancy varied with respect to walleye size. Food consumption rates in the ponds were related to walleye size (direct estimates) or water temperature (bioenergetics model estimates) but not zooplankton abundance. Growth exceeded 0.10 g g−1 d−1 for all but one sampling interval and the maximum growth rate in the culture pond fish was double the maximum growth rate determined in the laboratory. Growth was positively related to pond temperature and negatively related to walleye mass, but was not significantly related to zooplankton abundance. Gross conversion efficiency was negatively related to walleye mass, positively related to zooplankton abundance and not related to temperature. Food consumption and growth of walleye larvae in the field may be food-limited at much lower prey abundances than previous laboratory research has suggested.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1590-3478
    Keywords: Visual evoked potentials ; VEP ; Optic neuritis ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario I 20 pazienti affetti da Neurite Ottica (NO), descritti nel precedente lavoro [23] sono stati sottoposti a registrazioni seriali multicanali dei Potenziali Evocati Visivi (PEV), per un periodo di 2 anni dall'esordio della NO. I PEV potevano correlare con le lesioni evidenziate con la Risonanza Magnetica, con le alterazioni campimetriche e con altri reperti clinici. Basandoci sulla loro distribuzione in mappa, i PEV sono stati classificati come realmente “ritardati” e “pseudo-ritardati”. PEV realmente “ritardati” potevano essere registrati all'esordio, o precocemente dopo l'episodio di NO, e la presenza del “ritardo” stava ad indicare un recupero della funzione visiva e, quindi, una prognosi fausta. Gli “pseudo-ritardi” indicavano un'alterazione del campo visivo a prognosi non favorevole per un recupero della funzione visiva, a meno che entro i primi 3 mesi dalla NO si fosse verificata una ricomparsa di componenti normali o “ritardate”. Gli “pseudo-ritardi” erano rilievi caratteristici nei pazienti con lesioni maggiormente lunghe alle immagini LTE-STIR MRI [23]. Nessuna correlazione è stata trovata tra latenza dei PEV e lunghezza delle placche. I nostri rilievi sono in disaccordo con precedenti teorie relative ai tempi di instaurazione-recupero delle alterazioni di conduzione nella NO e nella Sclerosi Multipla.
    Notes: Abstract Twenty patients with optic neuritis (ON) described in the previous study [23] underwent serial VEP recordings (using multiple electrode arrays) for two years. The VEPs could be correlated with the lesions revealed by MRI, Visual Field tests and other clinical findings. On the basis of their scalp distribution, they were classified as “really delayed” VEPs and “pseudo-delayed” VEPs. Real delays could be recorded at the onset of ON or shortly afterwards, and their appearance indicated the recovery of visual function and a good prognosis. Pseudo-delays indicated an alteration in the visual field and, unless a breakthrough of normal or delayed components appeared in the first three months, following acute ON, indicate a poor prognosis for the recovery of visual function. The pseudo-delayed VEPs were mainly observed in patients with longer lesions revealed by means of LTE-STIR MRI [23]; there was no correlation between VEP latency and the length of plaques. Our findings contradict previous theories on the timing of conduction alterations in ON and multiple sclerosis.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-9686
    Keywords: Elastance ; Stroke volume ; Model ; Cardiomyoplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Dynamic cardiomyoplasty (DCM) is an emerging surgical procedure for heart failure in which the patient's latissimus dorsi (LD) muscle is wrapped around the heart and stimulated to contract in synchrony with the heartbeat as a cardiac assist measure. A 6 week training protocol of progressive electrical stimulation renders the normally fatigueable skeletal muscle fatigue-resistant and suitable for chronic stimulation. To date, over 500 procedures have been performed in worldwide clinical trials. Investigators typically report symptomatic improvement and modest hemodynamic improvement in patients. Controversy exists regarding the exact mechanism of DCM. To test the hypothesis that DCM augments cardiac stroke volume through improvement in systolic function, we formulated an engineering model of dynamic cardiomyoplasty to predict stroke volume. The heart and the LD were modeled as nested (series) elastance chambers, and the vasculature was represented by a two-element Windkessel model. Using five healthy goats, we verified model predictions of stroke volume for both stimulator ON beats (y=1.00x−0.08, r=0.87, p 〈 0.0001) and OFF beats (y=1.01x+1.06, r=0.91, p 〈 0.0001), where x and y are the measured and predicted stroke volumes, respectively. The model confirms that using untrained latissimus dorsi applied to the normal myocardium produces only moderate increases in stroke volume and suggests that future research should focus on increasing LD strength after training.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-9686
    Keywords: Clinical cardiomyoplasty ; Nomogram ; Muscle transformation ; Model ; Cardiomyoplasty ; Applications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Previously, a modification to the Sunagawa engineering model for the isolated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty patients, we predicted human stroke volume using the model with human clinical data from the literature. Predicted stroke volume correlated well with published stroke volume in patients who have had the dynamic cardiomyoplasty procedure. These results suggest that the modest hemodynamic improvement commonly reported after the procedure is performed may be due to diminished latissimus dorsi strength after transformation. The validity of both the original Sunagawa model and the previously proposed modification for dynamic cardiomyoplasty is further supported with these results. A nomogram methodology for predicting stroke volume after dynamic cardiomyoplasty for any particular patient is presented.
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