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  • 1995-1999  (14)
  • Chemistry  (9)
  • Key words Phenylketonuria  (3)
  • Secondary neoplasia  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 247-252 
    Details
    ISSN: 1432-0584
    Keywords: CLL ; Spontaneous remission ; Immunoglobulin deficiency ; Secondary neoplasia ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a 71-year-old patient with chronic lymphocytic leukemia diagnosed 27 years ago. Initially, the disease was staged as Rai II and the patient suffered from secondary immunoglobulin deficiency. Nevertheless, no treatment was necessary at that time. Because of disease progression a single course of chemotherapy was given in 1984. During the following year there was a constant decline of the WBC, accompanied by normalization of the immunoglobulins; both have remained stable ever since that time. However, there was still residual bone marrow infiltration, indicating persisting CLL. In 1993 cervical lymphadenopathy occurred with acute onset. A diagnostic lymphadenectomy revealed Hodgkin's disease of the nodular-sclerosing subtype. The patient was staged as II–III according to the Ann Arbor Classification and underwent radiation therapy. Cytogenetic examination of the bone marrow revealed a normal karyotype with an inversion of chromosome 9. This case demonstrates the rare coincidence of two lymphoproliferative disorders in the same patient. The clinical course and the immunologic findings of this patient are presented, together with a review of the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744374
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  • 2
    Electronic Resource
    Electronic Resource
    Hodgkin's disease developing after spontaneous remission of chronic lymphocytic leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 247-252 
    Details
    ISSN: 1432-0584
    Keywords: Key words CLL ; Spontaneous remission ; Immunoglobulin deficiency ; Secondary neoplasia ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We present a 71-year-old patient with chronic lymphocytic leukemia diagnosed 27 years ago. Initially, the disease was staged as Rai II and the patient suffered from secondary immunoglobulin deficiency. Nevertheless, no treatment was necessary at that time. Because of disease progression a single course of chemotherapy was given in 1984. During the following year there was a constant decline of the WBC, accompanied by normalization of the immunoglobulins; both have remained stable ever since that time. However, there was still residual bone marrow infiltration, indicating persisting CLL. In 1993 cervical lymphadenopathy occurred with acute onset. A diagnostic lymphadenectomy revealed Hodgkin's disease of the nodular-sclerosing subtype. The patient was staged as II-III according to the Ann Arbor Classification and underwent radiation therapy. Cytogenetic examination of the bone marrow revealed a normal karyotype with an inversion of chromosome 9. This case demonstrates the rare coincidence of two lymphoproliferative disorders in the same patient. The clinical course and the immunologic findings of this patient are presented, together with a review of the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744374
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of the brain in adolescents with phenyketonuria and in one case of 6-pyruvoyl tetrahydropteridine synthase deficiency (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S69 
    Details
    ISSN: 1432-1076
    Keywords: Key words Phenylketonuria ; Phenylalanine ; Magnetic resonance ; imaging ; Evoked potentials ; Myelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract White matter abnormalities on MRI have been observed in phenylketonuria (PKU) patients with late onset neurological symptoms as well as in neurologically inconspicious patients. We investigated 14 early treated adolescents at an age between 12 and 17 years (mean age 14.3 years) with classical PKU as well as one retarded patient with atypical PKU by cranial MRI with spinecho T1-, T2- and proton density sequences. Clinical examination was normal. Visual evoked potential (VEP) examination showed a prolonged latency of peak P100 (mean 122.6 ms; control mean 115.9) and IQ testing showed a mean IQ of 101.1. To investigate the influence of plasma phenylalanine (Phe) levels three approaches were used: Phe was determined for the day of MRI, for a period of 6 months prior to MRI and for lifetime up to 12 years. MRI scans revealed areas of abnormally increased signal intensity on T2-weighted and proton density images in 12 (86%) patients, preferably involving the parieto-occipital lobes. MRI of the patient with atypical PKU was normal. MRI findings correlated most strongly to long-term dietary control up to 12 years. We found no correlation with the other parameters of biochemical control, IQ or VEP latency. The nature and prognosis of MRI abnormalities in neurologically normal PKU patients remain unclear although abnormalities in VEPs which were not associated with the degree of MRI abnormalities in our sample indicate a disturbance in myelination along the visual pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014255
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  • 4
    Electronic Resource
    Electronic Resource
    Phenylalanine hydroxylase genotypes, predicted residual enzyme activity and phenotypic parameters of diagnosis and treatment of phenylketonuria (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S11 
    Details
    ISSN: 1432-1076
    Keywords: Key words Phenylketonuria ; Genotype ; Treatment ; IQ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interdependence of the predicted in vitro residual enzyme activity (PRA), as deduced from the complete genotypes of 64 hyperphenylalaninaemic patients, and parameters for diagnosis of hyperphenylalaninaemic disorders, the fluctuation of the phyenlylalanine (Phe) values during treatment, long-term dietary control during treatment, and a parameter for the outcome of therapy (IQ) was investigated by correlation analysis. A highly significant correlation was found between the PRA and diagnostic parameters, as well as the fluctuation of the Phe values during treatment. Significant correlations were also observed between the parameter describing the fluctuation of the Phe values and the IQ, as well as between the quality of dietary control and IQ. The PRA is a valuable tool for the differential diagnosis of hyperphenylalaninaemic disorders and for the prediction of one aspect of the course of the disease which is related to the intellectual outcome of therapy. The quality of dietary control was independent of the genotype, indicating that the outcome of therapy can be successfully manipulated in spite of the genetic make-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014222
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  • 5
    Electronic Resource
    Electronic Resource
    Intelligence and professional career in young adults treated early for phenylketonuria (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S97 
    Details
    ISSN: 1432-1076
    Keywords: Key words Phenylketonuria ; Intelligence ; Education ; Professional career ; Phenylalanine ; control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The intellectual status and professional careers of 51 young adults with phenylketonuria whose treatment started before 3 months of age are described. Their mean IQ was 97 (SD = 16). Of the IQs, 4% were more than 2 SD below the norm. The distribution of types of schooling of the patients was comparable to that in the German population. The professional careers of nearly all the patients were according to their educational level. Within the sample the outcome was significantly correlated with phenylalanine (Phe) control, even when the patients’ social background was statistically taken into account. The main influence of Phe on intelligence seems to occur during the first decade of life since IQ data remain stable even after Phe levels increased during adolescence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014262
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation and properties of composites of kevlar-nomex copolymer and boehmite (1997)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 248 (1997), S. 139-151 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Ein neuartiges organisch-anorganisches Hybridmaterial wurde durch den Einbau des Minerals Böhmit mittels eines Sol-Gel-Prozesses in ein Kevlar-Nomex-Copolymeres hergestellt. Durch Reaktion eines Gemisches aus m- und p-Phenylendiamin mit Terephthaloylchlorid und anschließender Umsetzung mit Aminophenyltrimethoxysilan wurden Poly(phenylenterephthalamid)-Ketten mit Aminophenyltri-methoxysilan-Endgruppen synthetisiert. In dieser Polymermatrix wurde die Hydrolyse der Alkoxygruppen einer Lösung von Aluminium-sec-butanolat in Butanol durchgeführt. Dadurch wurde ein chemisch an die Aramid-Ketten gebundenes anorganisches Netzwerk aufgebaut. Aus den hergestellten Hybridmaterialien mit unterschiedlichen Böhmit-Gehalten in der Aramidmatrix wurden Filme gegossen. Die Filme aus Hybridmaterial mit bis zu 15 Gew.-% Böhmit waren transparent gelb, während bei 20 und mehr Gew.-% Böhmit opake Filme erhalten wurden. Die mechanischen Eigenschaften dieser Filme wurden untersucht. Zugfestigkeit, Zugmodul, Härte und maximale Bruchdehnung nahmen mit steigendem Böhmitgehalt zunächst zu, vemngerten sich jedoch bei weiterer Erhöhung des Mineralanteils wieder. Der Zugmodul des Hybridmaterials bei 25°C lag zwischen 3,0 und 4,5 GPa. Die Materialien hielten einer maximalen Zugspannung von 252 MPa stand und zeigten Zersetzungstemperaturen von etwa 450°C. Die rnit DMTA ermittelten Werte für den Speichemodul lagen im Bereich 7,6-18,9 GPa. Das tan δ-Signal verbreiterte sich mit zunehmendem Böhmitanteil und ging bei hohen Böhmitgehalten in eine Schulter über. Die Signalpositionen des Verlustfaktors wurden infolge der zunehmenden sterischen Einschränkung der Segmentbewegungen rnit steigendem anorganischen Anteil zu höheren Temperaturen verschoben.
    Notes: A new organic-inorganic hybrid material was prepared by incorporating boehmite into a Kevlar-Nomex copolymer via a sol-gel process. Poly(phenylene-terephthalamide) chains having aminophenyltrimethoxysilane end groups were prepared by reacting a mixture of m-and p-phenylenediamine with terephthaloyl chloride, followed by end-capping with aminophenyltrimethoxysilane. The hydrolysis of the alkoxy groups of an aluminium sec-butoxide solution in butanol was carried out in the polymer matrix, thus creating an inorganic network structure combined chemically with the aramid chains. Hybrid materials containing different proportions of boehmite in aramid were thus produced and films were cast by solvent evaporation technique. These films with up to 15 wt.-% of boehmite were yellow and transparent, whereas the films with 20 wt.-% or more contents of boehmite were opaque. Mechanical properties of these films were analyzed. The values of tensile strength, initial modulus, toughness and maximum strain at rupture were initially found to increase and then decrease with further addition of boehmite. The tensile modulus of the hybrid material was found to be in the range of 3.0-4.5 GPa at 25°C. These ceramers were found to withstand maximum tensile stress of the order of 252 MPa, and the thermal decomposition temperature was around 450°C. The storage modulus as measured using DMTA was in the range of 7.6-18.9 GPa. The tan δ peak which in general became broader with increasing boehmite content showed a shoulder for composites containing large amounts of boehmite. The position of the peaks shifted towards high temperature with the increase in the inorganic contents showing hindrance in motion with increasing boehmite contents.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1997.052480109
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  • 7
    Electronic Resource
    Electronic Resource
    Neue Sol-Gel-Beschichtungen als Korrosions-und Verschleißschutz für NE-Metalle (1998)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 23-29 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: New Sol-Gel Based Coatings as Corrosion- and Wear-Protection On Non-Ferrous MetalsA new composite coating material has been developed for the protection of non-ferrous alloys (e.g. aluminum, magnesium, zinc and brass). The coating materials were prepared by the solgel process from epoxyalkoxysilanes and aromatic diols to act as crosslinking agents. As solvent, alcohols and glycol ethers have been used.The viscosity of the system (7-55 mPas) was established in a way to be used in spray, dip or flow coating processes. The transparent coatings were cured at T = 100-220°C. In corrosion tests, 3000 hours salt-spray climate and 240 hours CASS-test = Copper chloride and Acetic acid added Salt Spray, no infiltration of the metal-coating interface and no „filiform-corrosion“ on A199.5, AlMg3 and AlMgSil was observed. Brass samples showed less than 4 mm extension of a scribe after 500 hours salt-spray-test. The coatings showed no visible traces of abrasion after 1000 cycles taber abrader test and an excellent adhesion (cross cut and tape-test: grade 0). The transparent basic systems were pigmented by 5 - 10 wt.% of colored organic pigments to obtain all kind of colored coatings.
    Notes: Es wurde ein neuer Beschichtungswerkstoff auf Basis von anorganisch-organischen Kompositen zum Schutz von Metalloberflächen, besonders von Aluminium entwickelt. Das Beschichtungsmaterial wurde über den Sol-Gel-Prozeß synthetisiert, ausgehend von Epoxy-funktionalisierten Alkoxysilanen und aromatischen Diolen als Quervernetzer. Als Lösungsmittel wurden Alkohole und Glykolether verwendet.Die Viskosität der Systeme wurde so eingestellt, daß sowohl Sprüh-, als auch Tauch- und Flut-Beschichtungen durchgeführt werden konnten. Sie lag zwischen 7 und 55 mPas. Nach dem thermischen Verdichtungsprozeß bei 100-220°C wurden transparente Beschichtungen mit ausgezeichneter Haftung auf Al-Mg-, Zn-und Messing-Oberflächen (Gitterschnitt- und Tape-Test: Klasse 0) erhalten. Die Korrosionsfestigkeit beschichteter Aluminiumlegierungen (Al 99.5, AlMg3, AlMgSi I) wurde mit dem Salzsprühverfahren (DIN 50021) und dem CASS-Test (NaCl, CuCl2·2H2O, Essigsäure, pH=3) geprüft und auch nach 3000 Stunden trat keine Unterwanderung der Grenzfläche Metall / Schicht auf. Ebenso wurde keine „Filiform“-Korrosion beobachtet. Messingproben zeigten nach 500 h Salzsprühnebel-Test weniger als 4 mm mittlere Unterwanderungsbreite. Darüber hinaus wurde die Abriebbeständigkeit der Proben überprüft. Die Schichten zeigten keine sichtbare Beschädigung nach Prüfung des Abriebes mit dem Reibradverfahren (1000 Zyklen, Räder: CS 10-F).Es konnten stabile Dispersionen von organischen Farbpigmenten im transparenten Basissystem hergestellt werden, wodurch eine große Vielfalt farbiger Beschichtungen erhalten wurde.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19980290108
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  • 8
    Electronic Resource
    Electronic Resource
    Massenspektroskopische Charakterisierung von ω-ChloralkylphenylphosphanenHerrn Prof. Dr. Siegfried Engels (Halle/S.) anläßlich seines 65. Geburtstages gewidmet (1997)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 339 (1997), S. 482-484 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On the Mass Spectrometric Characterization of ω-Chloralkylphenylphosphines
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19973390187
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  • 9
    Electronic Resource
    Electronic Resource
    Modifikation von Titan durch Ionenimplantation-Ein Überblick (1997)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 28 (1997), S. 88-97 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Modification of Titanium by Ion Implantation-A ReviewThis paper reviews investigations concerning the effect of ion implantation on the properties of titanium alloys. The correlations between the process parameters and the phase formation in implanted layers, the wear and strength properties as well as the corrosion and oxidation behaviour are described. The application for joint prostheses is mentioned.
    Notes: Es wird ein Überblick über den Einfluß der Ionenimplantation auf die Eigenschaften von Titanlegierungen gegeben. Die Beziehungen zwischen den Prozeßparametern und der Phasenbildung in ionenimplantierten Schichten, den Verschleiß- und Festigkeitseigenschaften sowie dem Korrosions- und Oxidationsverhalten werden dargestellt. Die Anwendung für Gelenkprothesen wird kurz besprochen.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19970280210
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  • 10
    Electronic Resource
    Electronic Resource
    Gefüge und Korrosionsverhalten eines stickstofflegierten rostfreien Stahls (1998)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 29 (1998), S. 329-335 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Microstructure and Corrosion Behaviour of a Nitrogen Alloyed Stainless SteelThe corrosion behaviour of a nitrogen alloyed stainless steel is investigated using potentiodynamic anodic polarization in physiological NaCl solution. The microstructure of forged samples is determined by microscopy and hardness measurements. The steel shows a globular austenitic structure. In the zone of large forging deformation the grains are elongated. Precipitates are observed in which chromium and molybdenium are enriched. The breakdown potentials range from 200 to 1170 mV vs. SCE, most of the values exceed 500 mV. The breakdown potentials decrease with increasing aspect ratio of the grains and increasing hardness. The precipitates are initial sites for pitting and crater shaped metal dissolution.
    Notes: Das Korrosionsverhalten eines stickstofflegierten rostfreien Stahles wird durch potentiodynamische anodische Polarisation in physiologischer NaCl-Lösung untersucht. Der Gefügezustand geschmiedeter Proben wird mikroskopisch und durch Härtemessungen ermittelt. Der Stahl weist ein globulares austenitisches Gefüge auf, in der Zone starker Schmiedeverformung sind die Körner gestreckt. Es liegen Ausscheidungen vor, in denen Chrom und Molybdän angereichert sind. Der Stahl zeigt Durchbruchspotentiale zwischen 200 und 1170 mV vs. SCE, die meisten Werte liegen über 500 mV. Die Durchbruchspotentiale fallen mit zunehmendem Streckungsgrad der Körner und zunehmender Härte ab. Die Ausscheidungen sind Initialpunkte für loch- und kraterförmigen Materialabtrag.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19980290704
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