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  • 1995-1999  (4)
  • Cyclophosphamide  (2)
  • Key words Fibromyalgia  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 89-94 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Fibromyalgie ; Gruppentherapie ; Psychotherapie ; Key words Fibromyalgia ; group treatment ; psychotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Fibromyalgia is present in 2% of the general population and leads to impairment by chronic pain and fatigue. It does not improve without therapy directed at the symptoms of fibromyalgia. We describe our interdisciplinary group treatment for patients with fibromyalgia. They received a physical examination, ergometry and psychometric tests both at admission and before discharge, and they were questioned to the degree and localization of their pain, to fatigue, sleeping disorders and functional symptoms. Therapy included information about fibromyalgia, learning of coping strategies, relaxation and endurance training. Our results show that our interdisciplinary group treatment is effective for fibromyalgia and improves anxiety, depression and well being after a period of 5 weeks of in-patient rehabilitation.
    Notes: Zusammenfassung Die Fibromyalgie betrifft 2% der Bevölkerung und führt bei den Betroffenen zu einer deutlichen Beeinträchtigung durch chronische Schmerzen und Müdigkeit. Ohne gezielte Therapie bessern sich die Symptome der Fibromyalgie nicht. Wir behandelten Fibromyalgiepatienten interdisziplinär in Gruppen. Dabei wurden die Patienten bei Aufnahme und vor Entlassung ärztlich, leistungsphysiologisch und psychometrisch untersucht und zur Ausprägung und Lokalisation ihrer Schmerzen, zu ihrer Müdigkeit, Schlafstörungen und funktionellen Symptomen befragt. Die Behandlung schloß Informationen zum Krankheitsbild, Erlernen von Bewältigungsstrategien, Entspannungstechniken und Ausdauertraining ein. Unsere Untersuchungen zeigen, daß die ärztlich und psychologisch geleitete interdisziplinäre Gruppentherapie in der Behandlung der Fibromyalgie effektiv ist und am Ende der 5-wöchigen Behandlungsdauer Angst, Depression und Befindlichkeit der Fibromyalgiepatienten bessert.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. S36 
    ISSN: 0340-1855
    Keywords: Key words Fibromyalgia ; spinal column ; Schlüsselwörter Fibromyalgie ; Wirbelsäule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Fibromyalgie beobachtet man in gleicher Weise wie bei unspezifischen chronischen Lumbalgien klinisch und röntgenologisch sehr häufig Haltungsstörungen der Wirbelsäule, insbesondere Skoliosen. Darüber hinaus lassen sich ebenfalls bei beiden Erkrankungen in einem hohen Prozentsatz segmentale oder ausgedehnte Funktionsstörungen des Achsenorgans nachweisen. Vermutlich sind die Wirbelsäulenveränderungen oft für die Erstmanifestation der Fibromyalgie verantwortlich, die sich ja meist monolokulär vor allem in der Lumbal- und Cervicalregion findet. Die spätere Ausbreitung der Schmerzen erfolgt wahrscheinlich auf neuralen und muskulären Wegen, wobei psychische Faktoren akzentuierend wirken dürften.
    Notes: Summary In fibromyalgia as well as in low back pain we frequently find disturbances of the posture of vertebral column clinically and radiologically. Also, reduction in the mobility of whole spine and localized movement impairments in both conditions was present. It is likely that the disturbances are responsible for the first manifestations of fibromyalgia in a single localization, especially in lumbar and cervical regions.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1437-160X
    Keywords: Key words Lupus erythematosus ; Cyclophosphamide ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the long-term effect of intravenous pulse cyclophosphamide (CY) on lymphocyte surface antigens in systemic lupus erythematosus (SLE) patients. Blood samples derived from 17 lupus erythematosus patients were analysed using two- and three-colour flow cytometry. During the CY therapy, the total number of T lymphocytes (CD3+) was reduced by 31.4%, B lymphocytes (CD19+) by 67.4% and NK cells (CD16+) by 27.4%. Six months after the end of the CY regimen, these values recovered to entry levels. At the onset of the study we observed increased percentages of CD3+ CD25+, CD3+ CD4– CD8–, CD4+ CD29+, CD19+ and CD19+ CD5+ cells. The CY treatment regimen decreased the CD3+ CD25+, CD3+ CD4– CD8–, CD19+ and CD19+ CD5+ cells, but increased the CD3+ CD8+ subpopulation. Taken together, a deficiency of CD8+ T cells associated with CD4+ CD29+ predominance may imply an immune regulatory imbalance leading to abnormal CD4+ cell activation and in consequence to autoimmunity. Depletion of CD19+ cells combined with an enlargement of CD8 cells as a result of CY therapy may reduce the enhanced immune response in SLE patients.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 10 (1995), S. 199-201 
    ISSN: 1437-9813
    Keywords: Cystic hygroma ; Inoperable ; Cyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Surgical excision is considered the treatment of choice for cystic hygromas (CH). However, radical surgery may result in serious complications, and nerve palsy due to dissection occurs in 12% – 33% of cases in most series. Resection is especially difficult and sometimes impossible if the lesion involves the floor of the mouth, tongue, and larynx. Different alternative treatment modalities have been advocated in cases of life-threatening, unresectable CHs, however, most of them are associated with severe side effects and doubtful effectiveness. Two children with inoperable CHs of the head and neck are presented. Since intralesional injection of sclerosing agents was unsuccessful, they were treated with IV cyclophosphamide. In both patients tumor size markedly regressed and vital functions stabilized, even though only partial remission was obtained. Cyclophosphamide seems to be a useful and well-tolerated treatment alternative in children with unresectable life-threatening CHs.
    Type of Medium: Electronic Resource
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