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  • 1995-1999  (4)
  • Immunoelectron microscopy  (2)
  • Excitons and related phenomena (including electron-hole drops)  (1)
  • Exposure dose  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Calcitonin gene-related peptide- and substance P-immunoreactive axons in the nucleus gracilis of the rat with special reference to axonal dystrophy: light and electron microscopic observations (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 347-355 
    Details
    ISSN: 1432-0533
    Keywords: Key words Nucleus gracilis ; Axonal dystrophy ; Calcitonin gene-related peptide ; Substance P ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcitonin gene-related peptide (CGRP) and substance P (SP)-immunoreactive (IR) axons in the nucleus gracilis of normal rats (1–15 months of age) were studied by light and electron microscopy. Besides many CGRP-IR and SP-IR varicosities with normal appearance, we found a few swollen (nearly round or oval) varicosities with either CGRP or SP immunoreactivity. Swollen CGRP-IR varicosities were more frequently seen than SP-IR ones, appearing from 3 months of age and increasing in number and size (up to approximately 25 μm in diameter) with advancing age. At the electron microscopic (EM) level, CGRP-IR and SP-IR swollen varicosities showed dystrophic changes, i.e., many membranous dense bodies, and proliferation of microtubules and neurofilaments. CGRP-IR or SP-IR dystrophic axons also contained many mitochondria and sometimes made synaptic contacts with nonreactive dendrites (occasionally with non-IR axons). These findings suggest that the dystrophic CGRP and SP axonal profiles represent a functionally distinct subpopulation of axonal dystrophy in the nucleus gracilis and use CGRP or SP as a neuroactive substance. Using a double-immunostaining method, many of normal CGRP-IR axons were identified to be SP-IR. However, no single dystrophic varicosity was found to contain both CGRP and SP immunoreactivities. These findings suggest that CGRP and SP afferents are independently affected and progress to dystrophic changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315008
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Calcitonin gene-related peptide- and substance P-immunoreactive axons in the nucleus gracilis of the rat with special reference to axonal dystrophy: light and electron microscopic observations (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 347-355 
    Details
    ISSN: 1432-0533
    Keywords: Nucleus gracilis ; Axonal dystrophy ; Calcitonin gene-related peptide ; Substance P ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Calcitonin gene-related peptide (CGRP) and substance P (SP)-immunoreactive (IR) axons in the nucleus gracilis of normal rats (1–15 months of age) were studied by light and electron microscopy. Besides many CGRP-IR and SP-IR varicosities with normal appearance, we found a few swollen (nearly round or oval) varicosities with either CGRP or SP immunoreactivity. Swollen CGRP-IR varicosities were more frequently seen than SP-IR ones, appearing from 3 months of age and increasing in number and size (up to approximately 25 μm in diameter) with advancing age. At the electron microscopic (EM) level, CGRP-IR and SP-IR swollen varicosities showed dystrophic changes, i.e., many membranous dense bodies, and proliferation of microtubules and neurofilaments. CGRP-IR or SP-IR dystrophic axons also contained many mitochondria and sometimes made synaptic contacts with nonreactive dendrites (occasionally with non-IR axons). These findings suggest that the dystrophic CGRP and SP axonal profiles represent a functionally distinct subpopulation of axonal dystrophy in the nucleus gracilis and use CGRP or SP as a neuroactive substance. Using a double-immunostaining method, many of normal CGRP-IR axons were identified to be SP-IR. However, no single dystrophic varicosity was found to contain both CGRP and SP immunoreactivities. These findings suggest that CGRP and SP afferents are independently affected and progress to dystrophic changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315008
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Exciton dynamics within growth islands of GaAs/Al x Ga1−x As single quantum wells (1995)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 17 (1995), S. 1531-1536 
    Details
    ISSN: 0392-6737
    Keywords: Excitons and related phenomena (including electron-hole drops) ; Time-resolved optical spectroscopies and other ultrafast optical measurements in condensed matter ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary The localization dynamics of excitons within growth islands of GaAs/Al x Ga1−x As single quantum wells (SQW) have been investigated by time-resolved photoluminescence spectroscopy (TRPL). Several samples with different substrate misorientation and growth interruption times are compared with regard to the photoluminescence (PL) emission dynamics. For monolayer (ML) islands larger than the exciton radius,i.e. long growth interruption, the time evolution of the different PL peaks reflects the transfer of free excitons between growth islands as well as the localization within a single growth island. The samples with shorter growth interruption reveal a much less pronounced PL splitting due to ML islands. The dynamics appears to be mainly determined by exciton localization to thicker ML islands. The density of localization centres is larger for the sample grown on misoriented substrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02457239
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effect of the exposure dose of etoposide on the cell growth and cell kinetics of human ovarian cancer cells (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. 141-146 
    Details
    ISSN: 1432-0843
    Keywords: Key words Etoposide ; Cell kinetics ; Exposure dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although schedule-dependent cytotoxicity of etoposide has been reported, its mechanisms have not been elucidated fully. In this study, we attempted to clarify what concentration, time or exposure dose (ED, concentration of drug×time) of etoposide result in the antitumor effect on human ovarian cancer cells from the standpoint of cell cycle perturbation. The different ED were produced by different drug treatment schedules: 10 μg/ml×4 h (ED 40), 1.66 μg/ml×24 h (ED 40), 5 μg/ml×4 h (ED 20), 0.83 μg/ml×24 h (ED 20), 10 μg/ml×0.8 h (ED 8), 5 μg/ml×1.6 h (ED 8), 2 μg/ml×4 h (ED 8), 0.33 μg/ml×24 h (ED 8). Cell cycle perturbation on day 5 and the suppression of cell growth were dependent on the drug concentration at the lowest exposure dose (ED 8), but were dependent on ED at the higher EDs (20 or 40). The percentage of cells in the G2/M fraction significantly decreased from day 5 to day 7 in BG-1 cells treated at ED 20 or treated with higher concentrations (10 and 5 μg/ml) at ED 8, but not in those treated at ED 40 or treated with lower concentrations (2 and 0.33 μg/ml) at ED 8. Therefore, the cytotoxic mechanism of etoposide may not be explained by simple schedule dependency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050462
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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