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  • 1
    Electronic Resource
    Electronic Resource
    Predicting length-of-stay in preterm neonates (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 59-62 
    Details
    ISSN: 1432-1076
    Keywords: Key words Artificial neural network ; Neural networks computer ; Length-of-stay ; Preterm neonate ; Prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In neonatology, the early prediction of length-of-stay (LOS) may help in decision making. We retrospectively studied the accuracy of two LOS prediction models, namely a multiple linear regression model (MR) and an artificial neural network (ANN). Preterm neonates (n = 2144) were randomly assigned to a training-and-test (75%), or validation patient set (25%). A total of 40 first-day-of-life items (input data) and the date of discharge (output data) were routinely available. Training-and-test set data were used to identify input items with impact on LOS (input variables) using MR analysis to establish a MR prediction model and to train and test an ANN on those selected variables. Fed with validation set data, predicted LOS obtained from MR and ANN was compared individually with actual LOS. Predicted and actual LOS were highly correlated (for MR, r = 0.85 to 0.90; for ANN, r = 0.87 to 0.92). Conclusion Even first-day-of-life data may contain substantial information with which to predict individual length-of-stay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051010
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The “Pre-Molten Globule,” a New Intermediate in Protein Folding (1997)
    Springer
    The protein journal 16 (1997), S. 433-439 
    Details
    ISSN: 1573-4943
    Keywords: Pre-Molten globule ; folding intermediate ; NMR, proton exchange ; circular dichroism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In vitro folding studies of several proteins revealed the formation, within 2–4 msec, of transient intermediates with a large far-UV ellipticity but no amide proton protection. To solve the contradiction between the secondary structure contents estimated by these two methods, we characterized the isolated C-terminal fragment F2 of the tryptophan synthase β2 subunit. In β2, F2 forms its tertiary interactions with the F1 N-terminal region. Hence, in the absence of F1, isolated F2 should remain at an early folding stage with no long-range interactions. We shall show that isolated F2 folds into, and remains in, a “state” called the pre-molten globule, that indeed corresponds to a 2- to 4-msec intermediate. This condensed, but not compact, “state” corresponds to an array of conformations in rapid equilibrium comprising native as well as nonnative secondary structures. It fits the “new view” on the folding process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026397008011
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Local production of IgG and IgG subclasses in the aqueous humor of patients with Fuchs heterochromic cyclitis, herpetic uveitis and toxoplasmic chorioretinitis (1997)
    Springer
    International ophthalmology 21 (1997), S. 187-194 
    Details
    ISSN: 1573-2630
    Keywords: aqueous humor ; Fuchs heterochromic cyclitis ; IgG subclass ; herpetic uveitis ; toxoplasmic chorioretinitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in local immunity are important whenconsidering the physiopathology of uveitis. The aim ofthis study was to measure IgG and IgG subclassconcentrations in the serum and the AH of patients withthree different types of uveitis and to determine for eachof them the presence of a local production of IgG in theintra-ocular compartment. This investigation was extendedto IgG subclasses.Serum and AH of 46 patients, including 11 with Fuchsheterochromic cyclitis (FHC), 13 with toxoplasmicchorioretinitis, 11 with herpetic uveitis and 11 with senilecataract (taken as controls) were analyzed by ELISA forIgG and IgG subclasses. Three quotients (r1, IgG/albuminin serum; r2, IgG/albumin in AH; and R, r2/r1) werecalculated in order to estimate the local synthesis (LS) ofIgG and each IgG subclass.In AH of patients with herpetic uveitis, a concomitant andsignificant increase of all IgG subclasses as well asalbumin (with no significant increase of r2 or R) wasobserved. This finding was interpreted as an indirectconsequence of major damage to the blood–aqueousbarrier. In patients with FHC, a significant increase of r2and R involving only the IgG1 subclass was observed,indicating the existence of LS of IgG1 in the majority ofthese patients. In the AH of patients with toxoplasmicchorioretinitis, no significant modification of IgG subclassor albumin concentrations was observed when comparedto controls.In conclusion, it would seem interesting to considermeasurement of IgG and IgG subclasses and calculationof the coefficients r1, r2 and R for a better evaluation ofthe local immunological processes observed in differenttypes of uveitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005909331778
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    Paper (German National Licenses)
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