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  • 1
    Electronic Resource
    Electronic Resource
    Gastric adenoma — carcinoma sequence with special reference to p53 and Ki-ras gene alterations (1995)
    Springer
    Virchows Archiv 427 (1995), S. 119-124 
    Details
    ISSN: 1432-2307
    Keywords: p53 ; Ki-ras ; Gastric carcinoma ; Immunohistochemistry ; Polymerase chain reaction-single-strand conformational polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With the aim of detecting the timing of p53 and Ki-ras gene alterations in the gastric adenoma-carcinoma sequence, 19 early gastric adenocarcinomas arising from adenomas were studied. Immunohistochemically, 5 adenocarcinomas were positive for p53; 3 focally and 2 diffusely. The p53 point mutations were detected in a focal area with p53 immunoreactivity in 2 of the 5 p53-positive adenocarcinomas. This indicated that p53 point mutations may play a less crucial part in malignant conversion of adenoma to adenocarcinoma in the stomach than in the colon. No Ki-ras gene mutations at codons 12 and 13 were detected in any lesion. These results suggest that the adenoma-carcinoma sequence in the stomach has a different mechanism from that in the colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196515
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Complete Atrioventricular Septal Defect and Ebstein's Anomaly (1999)
    Springer
    Pediatric cardiology 20 (1999), S. 232-235 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Complete atrioventricular septal defect — Ebstein's anomaly — Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A case child with complete atrioventricular septal defect (AVSD) and Ebstein's anomaly underwent surgical treatment at 3 months of age. She died on the third postoperative day. Postmortem examination showed complete AVSD, downward displacement of the right atrioventricular valve, left ventricular outflow tract obstruction, and hypertensive pulmonary vascular disease. Association of complete AVSD and Ebstein's anomaly is a rare cardiac anomaly for which no attempt at surgical repair has previously been made. This report deals with our experience and also with the morphological features of this anomaly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900451
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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