ISSN:
1420-908X
Keywords:
Key words: JTE-522 — Adjuvant arthritis — Prostaglandin H synthase-2 (PGHS-2) — Bone change — Non-steroidal anti-inflammatory drugs (NSAIDs)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Objective and Design: To investigate the effect of JTE-522, a novel selective prostaglandin H synthase (PGHS)-2 inhibitor, on adjuvant-induced arthritis and bone changes.¶Subjects: Male Lewis rats at 8 weeks old were immunized with heat-killed mycobacteria.¶Treatment: JTE-522 (0.1–30 mg/kg) and indomethacin (0.1–3 mg/kg) were administered orally once-daily after immunization.¶Methods: Paw swelling, bone changes in arthritic paws and vertebrae, urinary levels of deoxypyridinoline and pyridinium crosslinks, and the incidence of gastric lesions were determined in arthritic rats.¶Results: JTE-522 (from 0.3 mg/kg) suppressed the development of paw swelling, and also reduced bone damage (score and bone mineral density) in arthritic paws and the urinary excretion of deoxypyridinoline and pyridinium crosslinks. However, JTE-522 did not cause gastric lesions even at 30 mg/kg in arthritic rats.¶Conclusions: These results suggest that JTE-522 possesses potent anti-arthritic activities and suppressive activity on inflammatory bone resorption without gastric side effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000110050316
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