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  • 1995-1999  (2)
  • Mutation spectrum  (1)
  • PACS: 75.70.Cn; 72.60.Tg; 73.50.Jt  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pulsed laser deposition of perovskite La0.5Sr0.5MnO3/La0.7Sr0.3CoO3 multilayers and their magnetotransport properties (1999)
    Springer
    Applied physics 69 (1999), S. S663 
    Details
    ISSN: 1432-0630
    Keywords: PACS: 75.70.Cn; 72.60.Tg; 73.50.Jt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. The perovskite La0.5Sr0.5MnO3-δ/La0.7Sr0.3CoO3-δ (LSMO/LSCO) bilayers and LSMO/LSCO/LSMO trilayers are fabricated by pulsed laser deposition and their magnetic and magnetoresistive properties are investigated. The “waist”-like magnetic hysteresis for both the bilayer and trilayer is explained in terms of the inter-layer exchange coupling model based on the large difference in coercivity between LSCO and LSMO layers. The shrink of hysteresis with temperature is attributed to the temperature dependence of the magnetic crystalline anisotropy and conduction band width W. We observe smoothed remnant resistance of the multilayers over a rather wide temperature range (〉100 K), while the magnetoresistance (MR) is not seriously damaged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003390051500
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Frequency and spectrum of p53 mutations in gastric cancer — a molecular genetic and immunohistochemical study (1995)
    Springer
    Virchows Archiv 426 (1995), S. 447-455 
    Details
    ISSN: 1432-2307
    Keywords: Gastric cancer ; p53 tumour-suppressor gene ; Mutation spectrum ; Dietary mutagens ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The p53 tumour-suppressor gene plays an important role in gastric carcinogenesis. In an analysis of the spectrum of mutations of the p53 gene seen in 56 primary gastric carcinomas of various types and grades of differentiation, the entire coding sequence (exons 2–11) of the p53 gene was screened by single-strand conformation polymorphism analysis and direct genomic sequencing of polymerase chain reaction products. Intragenic restriction site polymorphisms and the probe YNZ22 were used for the detection of loss of heterozygosity (LOH) of the p53 gene locus on chromosome 17p. p53 overexpression was studied with the anti-p53 antibody CM-1. A total of 21 somatic alterations of the p53 gene were found. Twenty were base-pair substitutions, and one was an eight base-pair deletion. Six tumours with p53 mutations revealed LOH. Abnormalities in p53 expression were found in 17 tumour samples, of which 16 had gene mutations. The spectrum of mutations observed was consistent with the predicted spectrum for dietary mutagens associated with the metabolism of nitrogenous compounds, resulting in deamination of nucleic acids. Our findings suggest that p53 could be a primary target for mutations associated with dietary carcinogens in gastric carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193167
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    Paper (German National Licenses)
    Fulltext
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