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  • 1995-1999  (2)
  • Numerical Methods and Modeling  (1)
  • p53 tumour-suppressor gene  (1)
  • 1
    ISSN: 1432-2307
    Keywords: Gastric cancer ; p53 tumour-suppressor gene ; Mutation spectrum ; Dietary mutagens ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The p53 tumour-suppressor gene plays an important role in gastric carcinogenesis. In an analysis of the spectrum of mutations of the p53 gene seen in 56 primary gastric carcinomas of various types and grades of differentiation, the entire coding sequence (exons 2–11) of the p53 gene was screened by single-strand conformation polymorphism analysis and direct genomic sequencing of polymerase chain reaction products. Intragenic restriction site polymorphisms and the probe YNZ22 were used for the detection of loss of heterozygosity (LOH) of the p53 gene locus on chromosome 17p. p53 overexpression was studied with the anti-p53 antibody CM-1. A total of 21 somatic alterations of the p53 gene were found. Twenty were base-pair substitutions, and one was an eight base-pair deletion. Six tumours with p53 mutations revealed LOH. Abnormalities in p53 expression were found in 17 tumour samples, of which 16 had gene mutations. The spectrum of mutations observed was consistent with the predicted spectrum for dietary mutagens associated with the metabolism of nitrogenous compounds, resulting in deamination of nucleic acids. Our findings suggest that p53 could be a primary target for mutations associated with dietary carcinogens in gastric carcinogenesis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 4313-4339 
    ISSN: 0029-5981
    Keywords: finite element ; stress modes ; classification ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A classification method is presented to classify stress modes in assumed stress fields of hybrid finite element based on the eigenvalue examination and the concept of natural deformation modes. It is assumed that there only exist m (=n-r) natural deformation modes in a hybrid finite element which has n degrees of freedom and r rigid-body modes. For a hybrid element, stress modes in various assumed stress fields proposed by different researchers can be classified into m stress mode groups corresponding to m natural deformation modes and a zero-energy stress mode group corresponding to rigid-body modes by the m natural deformation modes. It is proved that if the flexibility matrix [H] is a diagonal matrix, the classification of stress modes is unique. Each stress mode group, except the zero-energy stress mode group, contains many stress modes that are interchangeable in an assumed stress field and do not cause any kinematic deformation modes in the element. A necessary and sufficient condition for avoiding kinematic deformation modes in a hybrid element is also presented. By means of the m classified stress mode groups and the necessary and sufficient condition, assumed stress fields with the minimum number of stress modes can be constructed and the resulting elements are free from kinematic deformation modes. Moreover, an assumed stress field can be constructed according to the problem to be solved. As examples, 2-D, 4-node plane element and 3-D, 8-node solid element are discussed. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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