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  • 1995-1999  (3)
  • coupled conduction and radiation  (1)
  • galectins  (1)
  • reverse transcriptase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Sequence Analysis of the Polymerase Domain of HIV-1 Reverse Transcriptase in Naive and Zidovudine-Treated Individuals Reveals a Higher Polymorphism in α-Helices as Compared with β-Strands (1999)
    Springer
    Virus genes 18 (1999), S. 203-210 
    Details
    ISSN: 1572-994X
    Keywords: reverse transcriptase ; polymerase ; zidovudine ; α-helix ; β-strand ; polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a statistical analysis of genetic heterogeneity of the reverse transcriptase (RT)-coding region of human immunodeficiency virus type 1. Both newly determined sequences and sequences contained in the data banks have been examined. For the calculations, the viral samples and the regions within the RT molecule were divided in two groups. The viral samples were split into those from patients not subjected to antiretroviral therapy and those from patients treated with zidovudine (AZT, 3′-azido-3′-deoxythymidine) alone or in combination with other RT inhibitors. The RT-coding region was divided into segments encoding β-strands and segments encoding α-helices. A significantly lower heterogeneity was observed in β-strands relative to the α-helix coding segments. Application of the D test of Tajima has provided evidence of operation of negative (or purifying) selection in sequences from viruses of patients not subjected to antiretroviral treatment as well as in treated patients. In the group of untreated individuals, regions encoding β-strands are subjected to stronger negative selection than those encoding α-helices. It is likely that the observed differences reflect stronger functional constraints in β-strands than in α-helices of RT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008012101219
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Laser-Flash Diffusivity Measurement of Diamond Films (1998)
    Springer
    International journal of thermophysics 19 (1998), S. 951-959 
    Details
    ISSN: 1572-9567
    Keywords: coupled conduction and radiation ; diamond films ; diffusivity ; laser-flash stimulation ; semifitransparent films ; transient technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A laser-flash technique with fast infrared detection for the measurement of the normal diffusivity of samples, with a thickness in the range 200 to 700 μm, is presented. The experimental apparatus for such a measurement is described. Some points specific to the diffusivity measurement of semi-transparent and highly conductive materials such as diamond are discussed. Particularly, difficulties in connection with the good conductivity and low thickness of the samples we consider are pointed out. Finally, experimental results performed within the framework of the Diamond Round Robin 2 tests for both nondiamond and diamond films are presented and the influence of the coupled conductive–radiative heat transfer is shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022663611392
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Generation of H2O2 by Human Neutrophils and Changes of Cytosolic Ca2+ and pH of Rat Thymocytes in Response to Galactoside-Binding Proteins (Lectins or Immunoglobulins) (1997)
    Springer
    Bioscience reports 17 (1997), S. 219-230 
    Details
    ISSN: 1573-4935
    Keywords: Endogenous lectins ; galectins ; hydrogen peroxide ; biosignaling pathways
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In contrast to plant agglutinins, biological activities of animal/human lectins are not well defined yet. Testing a panel of seven mammalian carbohydrate-binding proteins we have found that the dimeric lectin from chicken liver (CL-16) was a stimulator of H2O2 release from human neutrophils as well as effector for induction of cytosolic Ca2+ and pH increase in rat thymocytes. Activity of this lectin was comparable to potent galactoside-specific plant lectins such as Viscum album L. agglutinin. The activities of the tested plant lectins depended significantly on their nominal carbohydrate specificity as well as on the source. The results indicate that endogenous lectins may be involved in the regulation of neutrophil and lymphocyte functions by elicitation of selective biosignaling reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027389614391
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    Paper (German National Licenses)
    Fulltext
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