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  • 11
    Electronic Resource
    Electronic Resource
    Preoperative Functional Magnetic Resonance Imaging (fMRI) of the Motor System in Patients with Tumours in the Parietal Lobe (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1223-1229 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Functional magnetic resonance imaging; fMRI; sensorimotor cortex; brain tumour.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Intracranial lesions may compromise structures critical for motor performance, and mapping of the cortex, especially of the motor hand area, is important to reduce postoperative morbidity. We investigated nine patients with parietal lobe tumours and used functional MRI sensitized to changes in blood oxygenation to define the different motor areas, especially the primary sensorimotor cortex, in relation to the localization of the tumour. Activation was determined by pixel-by-pixel correlation of the signal intensity time course with a reference waveform equivalent to the stimulus protocol. All subjects showed significant activation of the primary sensorimotor cortex while performing a finger opposition task with the affected and unaffected side. In five patients the finger opposition task additionally activated the ipsilateral sensorimotor cortex and the supplementary motor area (SMA). Extension and flexion of the foot, additionally performed in two patients, also activated the sensorimotor cortex, in one case within the perifocal oedema of the tumour. Tumour localization near the central sulcus induced displacement of the sensorimotor cortex as compared to the unaffected side in all patients with a relevant mass effect. The results of our study demonstrate that functional MRI at 1.5 T with a clinically used tomograph can reproducibly localize critical brain regions in patients with intracranial lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050242
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  • 12
    Electronic Resource
    Electronic Resource
    Atlanto-axial instability of a hypoplastic upper cervical spine (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 106-108 
    Details
    ISSN: 0942-0940
    Keywords: Atlanto-axial instability ; cervical spine ; hypoplasy ; cervical myelopathy ; surgical management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report on the development of myelopathy in a case of hypoplastic upper cervical spine with atlanto-axial instability. Its surgical treatment with transarticular screw fixation and interlaminar fusion is outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411446
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  • 13
    Electronic Resource
    Electronic Resource
    Acute subdural haematoma from ruptured intracranial aneurysms (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 163-167 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral aneurysm ; acute subdural haematoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute subdural haematoma (SDH) secondary to a raptured intracranial aneurysm is a rare event. Out of a total of 292 patients with a verified aneurysm (period 1986–1992) in five cases SDH was the diagnosis on CT-evaluation. One patient was in such a bad condition that no treatment was indicated. The remaining four patients were operated on: craniotomy and haematoma evacuation in two cases, craniotomy for haematoma evacuation and aneurysm-clipping in the other two cases. Two patients died and two achieved a good outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410620
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  • 14
    Electronic Resource
    Electronic Resource
    Restoration of expression of signal-transduction molecules in lymphocytes from patients with metastatic renal cell cancer after combination immunotherapy (1999)
    Springer
    Cancer immunology immunotherapy 48 (1999), S. 263-269 
    Details
    ISSN: 1432-0851
    Keywords: Key words Signal transduction ; Lymphocytes ; Immunotherapy ; Renal cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A decrease in lymphocyte signal-transduction molecules, described in cancer patients and patients with chronic infectious diseases, has been proposed as a possible mechanism leading to an impaired immune response in cancer patients. Here we report the effects of combination immunotherapy on the levels of T cell receptor ζ chain and p56lck tyrosine kinase in a retrospective study of cryopreserved lymphocytes from 26 metastatic renal cell carcinoma patients treated with high-dose interleukin-2 (IL-2), interferon α(INFα) and ex vivo IL-2-activated lymphocytes. Of the 26 patients, 12 were responders (5 complete and 7 partial) and 14 were non-responders (6 stable and 8 with progressive disease). Prior to treatment, 21 of 26 patients (81%) and 13 of 21 patients (62%) respectively expressed ζ chain and p56lck at less than 50% of the levels observed in healthy controls. During therapy, this low ζ chain and p56lck expression increased to at least 50% of normal in 13 of the 21 patients (62%) and in 6 of the 13 patients (46%) respectively; in the remaining patients expression levels remained at 50% of normal or more, or declined. Although, in this limited study, pretreatment levels of ζ and p56lck did not show significant correlation with antitumor response, 4 of 5 patients that achieved a complete response (80%) corrected bothζ chain and p56lck levels to at least 50% of normal, while restoration of both signal-transduction molecules to such levels was only observed in 3 of 7 partial responders (43%), 1 of 5 patients with stable disease (20%) and 2 of 7 patients with progressive disease (29%). Thus, these results suggest that analysis of changes in signal-transduction molecules may a be useful tool for immunological monitoring of patients throughout immunotherapy, and could provide important information for designing new clinical trials that restore impaired signal transduction while activating T cell responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050574
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  • 15
    Electronic Resource
    Electronic Resource
    Support Networks of Gay Male and Lesbian Youth (1998)
    Springer
    International journal of sexuality and gender studies 3 (1998), S. 27-46 
    Details
    ISSN: 1573-8167
    Keywords: gay ; lesbian ; youth ; support networks ; urban
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract The support networks of 90 self-identified urban gay male and lesbian youth (ages 14 to 21 years) are examined. The youth, who are predominantly black and Latino/a, indicated an average of eight persons in their support networks, most of whom were close friends. Other significant groups included were parents, siblings, other relatives, and lovers or partners. A large majority of the support network members knew that the youth were gay or lesbian. Youth were moderately to very satisfied with the support they received from the network members—being more satisfied with the support provided by those who knew of their homosexuality compared to those who suspected or were unaware. Nonetheless, most youth felt that they did not have enough friends, and that they often to seldom felt lonely. These two feelings correlated positively with suicide ideation and attempts; and feeling lonely also correlated positively with drug use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026252124173
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Typha control efficiency of a weed-cutting boat in the Lac de Guiers in Senegal: a preliminary study on mowing speed and re-growth capacity (1999)
    Springer
    Hydrobiologia 415 (1999), S. 249-255 
    Details
    ISSN: 1573-5117
    Keywords: Typha australis ; Senegal River ; Lac de Guiers ; mowing boat ; aquatic weed ; control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Prolific growth of Typha australis in the lower part of the Senegal River and the Lac de Guiers resulted from changed ecological conditions following the construction of two high dams in the Senegal River. Fluctuation of the water level has decreased markedly and the water has changed from brackish to fresh as the inflow of salt water from the ocean is prevented. The efficiency of a hydraulic weed cutting boat (model Conver 480 H) has been tested in various plots in the Lac de Guiers. This lake, connected with the Senegal River, is economically very important as it is the city of Dakar's major drinking water supply and also provides irrigation water for vast agricultural areas. Cutting, performed at 20 cm and 50 cm below the water surface, was very effective in removing Typha stands. However, due to the excessively thick stems of the Typha plants, cutting took much more time compared to similar operations in Europe. It was estimated that approximately 35 h were required to clear one ha of dense Typhastands. Directly after cutting re-growth was observed during a relatively brief period (approximately three months), however, subsequently all newly formed growth tips in the plots had suddenly disappeared. It was concluded that this sudden collapse was linked to a destruction of the root zone due to anoxic conditions. Eventual re-growth was relatively slow as after one year the plots were still largely free from Typha plants. Efficiency of mowing was not related significantly to depth of cutting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003877201612
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  • 17
    Electronic Resource
    Electronic Resource
    Survival strategy of Pistia stratiotes L. in the Djoudj National Park in Senegal (1999)
    Springer
    Hydrobiologia 415 (1999), S. 21-27 
    Details
    ISSN: 1573-5117
    Keywords: Pistia stratiotes ; seed formation ; flowering ; habitat factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The water level in the Senegal River is now regulated due to the construction of two high dams (1986 and 1988). In consequence, large parts of the floodplains have permanently dried up and the brackish water in the lower part of the river has become fresh. The Djoudj National Park, situated approximately 60 km upstream from Saint Louis in Senegal in the former floodplain, is artificially flooded when inlets from the river are opened during the rainy season. This change in ecological conditions has led to an annually recurrent, explosive development of the floating aquatic weed Pistia stratiotes L. in the Park during the first half of the dry season. A rapid increase in the salt content of the water in the Park, in the course of the dry season (due to the high salt content of the soils and evaporation), eventually causes massive die back of Pistia. Rapid seed production by Pistia permits it to survive these unfavourable conditions, i.e. high salinity coupled with drought during the second half of the dry season. This applies in particular to an area where the water is fertilised by excreta from a pelican colony. Flowering of Pistiaappears to be markedly enhanced when vegetative reproduction is inhibited by crowding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003817213753
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  • 18
    Electronic Resource
    Electronic Resource
    Nonradioactive Northern blotting with biotinylated and digoxigenin-labeled RNA probes (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 1351-1355 
    Details
    ISSN: 0173-0835
    Keywords: Stripping ; Chemiluminescence ; Alkaline phosphatase ; Nonradioactive blotting ; Peroxidase ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The application of nonradioactive RNA probes for Northern blotting offers the advantage of a rapid turn-around time for results without the loss of sensitivity for target mRNA detection. However, a problem that has impeded the widespread use of nonradioactive RNA probes for use in Northern blotting is the difficulty in stripping these probes from nylon membranes after hybridization. In this report we describe two protocols for stripping digoxigenin (Dig)-labeled RNA probes from nylon membranes. One protocol utilizes a phosphate-buffered formamide stripping solution to remove nonchemically modified (regular) RNA probes while the other method utilizes strippable probes that were produced with a chemically modified nucleotide (CTP) and removed by a specific stripping solution. This latter method was developed by Ambion Inc. and is called Strip-EZ™. We also describe a protocol for the detection of two separate rat mRNAs using both biotin and digoxigenin-labeled RNA probes that does not require stripping the membrane after hybridization. Finally, we describe the use of another new labeling technology, called ChemLink™, that quickly and conveniently labels RNA for use in Northern blotting.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150190825
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