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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of Borrelia afzelii from circumscribed scleroderma (1999)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 45-year-old man presented with circumscribed scleroderma (CS) on the extremities. Histology of lesional skin showed the typical manifestations of scleroderma including a perivascular and interstitial infiltrate of lymphocytes and plasma cells; in one of the biopsies spirochaetes could be detected. Despite treatment with penicillin, progression of CS was observed and spirochaetes were isolated from skin cultures obtained from active scleroderma lesions. These spirochaetes were identified as Borrelia afzelii by sodium dodecyl sulphate–polyacrylamide gel electrophoresis of outer surface proteins and polymerase chain reaction (PCR) analysis of their chromosome. After two courses with ceftriaxone the lesions stopped expanding and sclerosis of the skin was diminished. At this time cultures for spirochaetes and PCR of lesional skin for Borrelia afzelii DNA remained negative. The pathogenetic role of Borrelia afzelii in the development of CS is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.02828.x
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphoproliferative responses to Borrelia burgdorferi in circumscribed scleroderma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Humoral immune responses to Borrelia hurgdorferi (Bb) have been reported to occur in certain patients with circumscribed scleroderma (CS) (morphoea). Together with the isolation of spiro-chaetes from CS skin biopsies, this finding was taken to suggest Bb as the aetiological agent of CS. Since there is cellular immunoreactivity to Bb in patients with chronic Lyme borreliosis (LB). Bb-specific lymphocytic responses were tested in patients with CS. For this purpose, peripheral blood mononuclear cells from CS patients and. as controls, from patients with various manifestations of LB, and from healthy volunteers without any evidence of Bb infection, were exposed to Bb organisms for 5 days and then assayed for DNA synthesis. Stimulation indices (SI)〉 10 were scored positive. By performing lymphocyte proliferation tests we found: (i) that not only patients with various manifestations of LB but also a considerable percentage of seropositive (five of 13 = 38%) and seronegative (six of 26 = 23%) CS patients exhibit an elevated Bb-induced lymphocyte proliferation; (ii) that the magnitude of the cellular response seen in CS patients is comparable to that encountered in patients with established Bb manifestations; and (iii) that, within a given patient, antibiotic therapy can result in a significant reduction of this response. These results support a causative role of Bb in at least some CS patients. Bb-induced lymphocyte responses were also seen in both seropositive and seronegative erythema chronicum migrans patients. These findings show that the pattern of Bb-specific immune responses is more complex than previously thought, and underscore the importance of lymphocyte function assays in evaluating the diagnosis of potential Bb infection in seronegative patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07615.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ekkrine Hidradenitis Kasuistik und Literaturübersicht (1997)
    Springer
    Der Hautarzt 48 (1997), S. 743-748 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Ekkrine Hidradenitis ; Idiopathische Neutropenie ; G-CSF ; Nebenwirkungen ; Key words Eccrine hidradenitis ; Idiopathic neutropenia ; G-CSF ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Neutrophilic eccrine hidradenitis is a self-limited dermatosis with spontaneous resolution. The clinical presentation and location of the lesions are variable. Histopathologically, neutrophilic eccrine hidradenitis is characterized by a predominantly neutrophilic or mononuclear infiltrate around the eccrine ducts with associated necrosis. Possible causes include malignant hematological disorders, tumors, side effects of chemotherapy and bacteria infections. We report a 16-month-old female patient with idiopathic neutropenia undergoing G-CSF therapy, who suddenly developed numerous papules on her trunk and extremities. The lesions resolved spontaneously within 6 weeks without treatment. The clinical and histopathological findings of the hitherto published 45 cases are reviewed.
    Notes: Zusammenfassung Die neutrophile ekkrine Hidradenitis ist eine selbstlimitierende Dermatose mit spontaner Heilungstendenz. Das klinische Bild und die Lokalisation der Läsionen sind vielfältig. Histopathologisch ist diese Dermatose durch ein Infiltrat von neutrophilen Granulozyten im Bereich von ekkrinen Schweißdrüsengängen in Assoziation mit Nekrosen der Schweißdrüsen charakterisiert. Als pathogenetische Ursachen werden maligne hämatologische Erkrankungen, maligne Tumoren, Nebenwirkungen von Chemotherapeutika sowie bakterielle Noxen diskutiert. Wir berichten über eine 16 Monate alte Patientin mit idiopathischer Neutropenie unter G-CSF Therapie, bei der plötzlich zahlreiche papulöse Hautveränderungen am Bauch und an den Extremitäten auftraten und nach 6 Wochen spontan abheilten. Zusätzlich werden in dieser Arbeit die klinischen und histopathologischen Veränderungen der 45 bisher publizierten Fälle zusammengefaßt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050654
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    Paper (German National Licenses)
    Fulltext
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