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  • 1
    Digitale Medien
    Digitale Medien
    Downregulation of class II molecules on epidermal Langerhans cells in Lyme borreliosis (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Borrelia burgdorferi can be isolated from the skin of patients with acrodermatitis chronica atrophicans (ACA), a late-stage manifestation of Lyme borreliosis; despite a marked T-cell infiltrate in lesional skin and high antibody titres in patients’ sera. Objectives To determine whether antigen-presenting Langerhans cells (LCs), which reportedly show signs of injury in erythema chronicum migrans (ECM), the early stage of disease, are altered in ACA. Patients/Methods We studied the immunophenotype of cutaneous leucocytes on cryostat sections of lesional skin from both ECM and ACA patients. Results The total number of CD1a+ cells evaluated by semiautomatic image analysis was lower in ECM (594 ± 263 cells mm−2 epidermis) than in ACA (835 ± 317 cells mm−2 epidermis). HLA-DR expression was remarkably downregulated on CD1a+ LCs to 29% in ECM and 18% in ACA, whereas in normal skin, most of the epidermal CD1a+ dendritic cells were HLA-DR+. The inflammatory infiltrate was mainly composed of CD68+ macrophages and CD45RO+ memory T cells, with a predominance of CD4+ helper T cells. Conclusions It is conceivable that the downregulation of major histocompatibility complex class II molecules on LC in both the early and late skin manifestations of Lyme borreliosis is indicative of a poorly effective anti-B. burgdorferi immune response and thus at least partly responsible for the insufficient elimination of this micro-organism from ACA skin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03776.x
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  • 2
    Digitale Medien
    Digitale Medien
    Incidence of Chancroid in Vienna From 1980 to 1988 (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 28 (1989), S. 0 
    Details
    ISSN: 1365-4632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: : The authors report on a retrospective study of the occurrence of chancroid in the city of Vienna during the past 10 years. After identifying two patients at the authors' department with chancroid in March 1988, the authors investigated the frequency with which this disease presented during the last 10 years. Of 32 patients, six presented between 1977 and 1980, and one patient in 1987. The remaining 25 patients were diagnosed within a 4-month period in 1981, suggesting a limited outbreak. The source of this infection could be traced to Turkey; infected prostitutes contributed to further spread in Vienna. All patients were treated successfully with sulfamethoxazole/trimethoprim. Efficient control of this outbreak can be attributed to inpatient treatment of the prostitutes. Appropriate and timely treatment must be proceeded by careful and exact diagnosis of this disease whose clinical picture is constantly diverging from its classical form.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-4362.1989.tb02487.x
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  • 3
    Digitale Medien
    Digitale Medien
    Acute exacerbation of systemic scleroderma in Borrelia burgdorferi infection (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    Details
    ISSN: 1468-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In recent years a possible aetiological connection between skin sclerosis and an infection with Borrelia burgdorferi has been discussed, but this association has not yet been reported for systemic scleroderma. Several treatment modalities are suggested for systemic scleroderma, but no treatment has yet been found to alter the overall course of the disease. This report describes a 61-year-old woman with Raynaud's phenomenon, nail-fold changes and circulating anticentromere antibodies, who showed an abrupt onset of erythemas and doughy swellings involving the face and upper trunk, followed by thickening and induration of the skin mimicking diffuse systemic scleroderma. Laboratory tests including enzyme-linked immunosorbent assay (ELISA), immunoblot and urine polymerase chain reaction (PCR) showed an infection with B. burgdorferi sensu lato that was successfully treated with intravenous ceftriaxone, an antibiotic recommended for Lyme borreliosis. Fourteen days after the end of treatment the skin was no longer stiff and indurated and had returned to its normal predisease state. This case suggests that Lyme disease should be considered in atypical cases of skin sclerosis in patients predisposed to the development of systemic scleroderma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1468-3083.2004.01074.x
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  • 4
    Digitale Medien
    Digitale Medien
    Isolation and polymerase chain reaction typing of Borrelia afzelii from a skin lesion in a seronegative patient with generalized ulcerating bullous lichen sclerosus et atrophicus (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A 64-year-old woman presented with bullous and ulcerating lichen sclerosus et atrophicus (LSA) on the neck, trunk, genital and perigenital area and the extremities. Histology of lesional skin showed the typical manifestations of LSA; in one of the biopsies spirochaetes were detected by silver staining. Despite treatment with four courses of ceftriaxone with or without methylprednisone for up to 20 days, progression of LSA was only stopped for a maximum of 1 year. Spirochaetes were isolated from skin cultures obtained from enlarging LSA lesions. These spirochaetes were identified as Borrelia afzelii by sodium dodecyl sulphate–polyacrylamide gel electrophoresis and polymerase chain reaction (PCR) analyses. However, serology for B. burgdorferi sensu lato was repeatedly negative. After one further 28-day course of ceftriaxone the lesions stopped expanding and sclerosis of the skin was diminished. At this time cultures for spirochaetes and PCR of lesional skin for B. afzelii DNA remained negative. These findings suggest a pathogenetic role for B. afzelii in the development of LSA and a beneficial effect of appropriate antibiotic treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04034.x
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  • 5
    Digitale Medien
    Digitale Medien
    Isolation of Borrelia afzelii from circumscribed scleroderma (1999)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A 45-year-old man presented with circumscribed scleroderma (CS) on the extremities. Histology of lesional skin showed the typical manifestations of scleroderma including a perivascular and interstitial infiltrate of lymphocytes and plasma cells; in one of the biopsies spirochaetes could be detected. Despite treatment with penicillin, progression of CS was observed and spirochaetes were isolated from skin cultures obtained from active scleroderma lesions. These spirochaetes were identified as Borrelia afzelii by sodium dodecyl sulphate–polyacrylamide gel electrophoresis of outer surface proteins and polymerase chain reaction (PCR) analysis of their chromosome. After two courses with ceftriaxone the lesions stopped expanding and sclerosis of the skin was diminished. At this time cultures for spirochaetes and PCR of lesional skin for Borrelia afzelii DNA remained negative. The pathogenetic role of Borrelia afzelii in the development of CS is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.02828.x
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  • 6
    Digitale Medien
    Digitale Medien
    Lymphoproliferative responses to Borrelia burgdorferi in circumscribed scleroderma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Humoral immune responses to Borrelia hurgdorferi (Bb) have been reported to occur in certain patients with circumscribed scleroderma (CS) (morphoea). Together with the isolation of spiro-chaetes from CS skin biopsies, this finding was taken to suggest Bb as the aetiological agent of CS. Since there is cellular immunoreactivity to Bb in patients with chronic Lyme borreliosis (LB). Bb-specific lymphocytic responses were tested in patients with CS. For this purpose, peripheral blood mononuclear cells from CS patients and. as controls, from patients with various manifestations of LB, and from healthy volunteers without any evidence of Bb infection, were exposed to Bb organisms for 5 days and then assayed for DNA synthesis. Stimulation indices (SI)〉 10 were scored positive. By performing lymphocyte proliferation tests we found: (i) that not only patients with various manifestations of LB but also a considerable percentage of seropositive (five of 13 = 38%) and seronegative (six of 26 = 23%) CS patients exhibit an elevated Bb-induced lymphocyte proliferation; (ii) that the magnitude of the cellular response seen in CS patients is comparable to that encountered in patients with established Bb manifestations; and (iii) that, within a given patient, antibiotic therapy can result in a significant reduction of this response. These results support a causative role of Bb in at least some CS patients. Bb-induced lymphocyte responses were also seen in both seropositive and seronegative erythema chronicum migrans patients. These findings show that the pattern of Bb-specific immune responses is more complex than previously thought, and underscore the importance of lymphocyte function assays in evaluating the diagnosis of potential Bb infection in seronegative patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb07615.x
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  • 7
    Digitale Medien
    Digitale Medien
    Immunoperoxidase Staining of Spirochetes in Borrelial Skin Diseases (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 539 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb31870.x
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  • 8
    Digitale Medien
    Digitale Medien
    Ekkrine Hidradenitis Kasuistik und Literaturübersicht (1997)
    Springer
    Der Hautarzt 48 (1997), S. 743-748 
    Details
    ISSN: 1432-1173
    Schlagwort(e): Schlüsselwörter Ekkrine Hidradenitis ; Idiopathische Neutropenie ; G-CSF ; Nebenwirkungen ; Key words Eccrine hidradenitis ; Idiopathic neutropenia ; G-CSF ; Side effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Neutrophilic eccrine hidradenitis is a self-limited dermatosis with spontaneous resolution. The clinical presentation and location of the lesions are variable. Histopathologically, neutrophilic eccrine hidradenitis is characterized by a predominantly neutrophilic or mononuclear infiltrate around the eccrine ducts with associated necrosis. Possible causes include malignant hematological disorders, tumors, side effects of chemotherapy and bacteria infections. We report a 16-month-old female patient with idiopathic neutropenia undergoing G-CSF therapy, who suddenly developed numerous papules on her trunk and extremities. The lesions resolved spontaneously within 6 weeks without treatment. The clinical and histopathological findings of the hitherto published 45 cases are reviewed.
    Notizen: Zusammenfassung Die neutrophile ekkrine Hidradenitis ist eine selbstlimitierende Dermatose mit spontaner Heilungstendenz. Das klinische Bild und die Lokalisation der Läsionen sind vielfältig. Histopathologisch ist diese Dermatose durch ein Infiltrat von neutrophilen Granulozyten im Bereich von ekkrinen Schweißdrüsengängen in Assoziation mit Nekrosen der Schweißdrüsen charakterisiert. Als pathogenetische Ursachen werden maligne hämatologische Erkrankungen, maligne Tumoren, Nebenwirkungen von Chemotherapeutika sowie bakterielle Noxen diskutiert. Wir berichten über eine 16 Monate alte Patientin mit idiopathischer Neutropenie unter G-CSF Therapie, bei der plötzlich zahlreiche papulöse Hautveränderungen am Bauch und an den Extremitäten auftraten und nach 6 Wochen spontan abheilten. Zusätzlich werden in dieser Arbeit die klinischen und histopathologischen Veränderungen der 45 bisher publizierten Fälle zusammengefaßt.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001050050654
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  • 9
    Digitale Medien
    Digitale Medien
    Evidence for spirochetal origin of Sudeck's atrophy (algodystrophy, reflex sympathetic dystrophy) (1989)
    Springer
    Archives of orthopaedic and trauma surgery 108 (1989), S. 314-316 
    Details
    ISSN: 1434-3916
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Vier weibliche Patienten mit Sudeck'scher Atrophie wurden in Hinblick auf eine mögliche Infektion mitBorrelia burgdorferi, dem Erreger der Lyme disease, untersucht. Bei allen Patienten fanden sich im Serum erhöhte IgG-Antikörper, bei einer Patientin auch erhöhte IgM-Antikörper gegenBorrelia burgdorferi. Bei einer Patientin konnten auf histologischen Schnitten Strukturen, identisch mitBorrelia burgdorferi, nachgewiesen werden. Unsere Ergebnisse und die anderer Autoren zeigen, daß eine Infektion mitBorrelia burgdorferi bei der Entstehung des Morbus Sudeck eine wichtige ätiopathogenetische Rolle spielen könnte.
    Notizen: Summary Four female patients with Sudeck's atrophy (SA) were evaluated at our department. Sera of all patients were investigated for antibodies againstBorrelia burgdorferi. In all patients elevated IgG antibody titers and in one patient also elevated IgM titer were found. In one patient structures identical withB. burgdorferi could be detected on histological sections from the skin of the affected limb. Our data and those of other authors suggest that a spirochetal infection can be regarded as an important etiopathogenetic factor in the development of SA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932322
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