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  • 1995-1999  (6)
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  • 1
    Digitale Medien
    Digitale Medien
    A clinicopathological study of adult Japanese IgA nephropathy patients: Early stage cases and cases with exacerbation (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 3 (1997), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: Most cases of adult type IgA nephropathy (IgAN) have an insidious onset and asymptomatic course. However, some patients reveal recurrent macroscopic haematuria following episodes of respiratory or urinary tract infections. In order to clarify the correlation between clinical features and histological alterations or prognosis, 42 cases of early stage IgAN and 40 cases with acute exacerbation episodes were investigated and compared with a control group. Early stage cases were defined as having had a renal biopsy within 1 year after the first detection of urinary abnormalities, and had normal urinary findings within the 12 months before the first detection of urinary abnormalities. Acute exacerbation cases were defined as macroscopic haematuria or worsening of urinary abnormalities after acute infectious episodes and undergoing a renal biopsy within 120 days after the onset of these episodes. the early stage cases had better renal function and lower systolic and diastolic blood pressure than that of control group. They also showed milder changes in mesangial cell proliferation, mesangial matrix increase, totally sclerotic glomeruli, and tubulo-interstitial changes. However, it is important to note that glomerular and interstitial sclerotic changes were observed even in early stage cases. Endothelial detachment was noticed more frequently in the early stage cases. Acute exacerbation cases revealed lesions of endocapillary proliferation, mesangiolysis and endothelial detachment more frequently, although these changes were segmental in each glomerulus. There was no statistical difference in disease prognosis between cases with and without acute exacerbation. These data indicated that there are characteristic histological changes in early stage cases and acute exacerbation cases of IgAN.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1997.tb00288.x
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  • 2
    Digitale Medien
    Digitale Medien
    24R, 25-Dihydroxyvitamin D3 ameliorates the high-turnover bone diseases without suppressing parathyroid function in chronic renal failure in rats (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 2 (1996), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: To evaluate the effect of 24R,25-dihydroxyvitamin D3 (24,25D) on uraemic bone disease, we treated the model rats of mild renal failure either with 0.5 μg/kg bodyweight (BW) of 24,25D, or with 5 μg/kg BW of 24,25D, or with 0.01 μg/kg BW of 1,25-dihydroxyvitamin D3 (1,25D), or with 0.01 μg/kg BW of 1,25D and 0.5 μg/kg BW of 24,25D, or with vehicle alone, given orally for 16 weeks. the examination of bone histology revealed extreme acceleration of bone turnover and decreased trabecular bone volume with elevated serum parathyroid hormone (PTH) level in vehicle-treated uraemic rats compared with those of sham-operated rats. Treatment with 24,25D (5 μg/kg BW) not only ameliorated high-turnover bone disease as with 1,25D, but also prevented the reduction of trabecular bone volume without any changes of serum PTH levels, suggesting the possible direct effect of 24,25D on the bone. Our data suggest 24,25D may be another useful agent for the treatment of high-turnover bone disease caused by secondary hyperparathyroidism in chronic renal failure, with less suppression of parathyroid function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1996.tb00114.x
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  • 3
    Digitale Medien
    Digitale Medien
    Histomorphometric analysis of aplastic bone disease in chronic renal failure at initiation of haemodialysis: Relation to aluminum and parathormone (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: SUMMARY: We studied bone histology of 134 uraemic patients without a history of vitamin D administration at the start of haemodialysis. Patients were categorized according to bone histology as follows: aplastic bone disease (ABD), ostitis fibrosa, mixed type, mild hyperparathyroidism and osteomalacia. On initiation of haemodialysis, ABD was observed in 48.5% of patients. the average age of the ABD group (50.8 ± 12.5 years) was significantly higher than that of patients with other histologies (P〈0.01). Serum parathyroid hormone (PTH) and alkaline phosphatase (ALP) concentrations were lower (P〈0.01) in the ABD group, especially in patients with diabetes mellitus. Patients with diabetes mellitus and ABD had lower serum concentrations of PTH and ALP than non-diabetic patients, suggesting that depressed PTH may be related to ABD. Eleven (55%) of the 20 patients who were receiving A1(OH)3 also had ABD. A direct relationship was observed between serum aluminum concentration and aluminum-positive bone surface (r=0.60; P〈0.01). Aluminum staining was more frequently observed in the ABD group than in the non-ABD group (P〈0.01). Because serum intact-PTH concentrations correlate with osteoid surface area, fibrosis volume and bone formation rate, it may be a useful marker of bone histology in renal osteodystrophy. These results suggest that, in addition to conservative treatment with A1(OH)3, other factors may be involved in the formation of ABD which is often present at the start of haemodialysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1797.1998.d01-21.x
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  • 4
    Digitale Medien
    Digitale Medien
    No linkage to the COL4A3 gene locus in Japanese thin basement membrane disease families (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 1 (1995), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: Patients with thin basement membrane disease (TBMD) exhibit persistent haematuria with a diffuse thinning of the glomerular basement membrane (GBM), especially of the lamina densa. It appears to be an autosomal dominant trait. It has been reported that the Goodpasture epitope, which is located in the non-collagenous domain of type IV collagen α 3 chain, may be reduced in patients with TBMD. We speculated that the candidate gene for TBMD could be the type IV collagen α 3 chain gene (COL4A3), which is present closely to type IV collagen α 4 chain gene (COL4A4) on chromosome 2q35–37. We conducted a linkage analysis to investigate the relationship between familial TBMD and COL4A3 gene, using COL4A3 cDNA polymorphism and a (CA)n microsatellite marker located in the COL4A3 gene. We examined 32 individuals from four Japanese families with TBMD. There were no associations between the patients with haematuria and certain alleles of the two markers in the pedigrees of three families. It has been reported that type IV collagen α 1 chain gene (COL4A1) and α 2 chain gene (COL4A2) are not involved in TBMD, and that α 5 chain gene (COL4A5) and a 6 chain gene (COL4A6) map to chromosome X. In conclusion, our findings suggested that familial TBMD is not caused by the genetic abnormalities of type IV collagen genes isolated thus far.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1995.tb00046.x
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  • 5
    Digitale Medien
    Digitale Medien
    Histocytochemical study of Spot 35-calbindin-D28K and Ca2+-ATPase in rat kidney (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 1 (1995), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary: We determined the distribution of Spot 35-calbindin-D28K, a vitamin-D dependent calciumbinding protein, in rat kidney using histochemical methods and compared it with the distribution of Ca2+-ATPase activity. Spot 35-calbindin-D28K immunoreactivity was localized in the cytosol of urinary epithelial cells in distal convoluted tubules (DCT), connecting tubules (CNT) and cortical collecting ducts (CCD), identifying the physiologically confirmed site of active transcellular calcium transport. In the cytosol, the immunoreactivity was clustered near the luminal plasma membrane and around the mitochondria. These findings indicated that Spot 35-calbindin-D28K seemed to have a cytosolic calcium buffering effect in the urinary tubular epithelial cells. Enzyme histochemical analysis showed that Ca2+-ATPase activity was localized at the basolateral plasma membrane of distal nephron segments and was strongest at the cortical thick ascending limb of Henle (CTAL), including the macula densa portion. Ca2+-ATPase activity was not evident in DCT, CNT or CCD. Strong Ca2+-ATPase activity and Spot 35-calbindin-D28K immunoreactivity did not coexist in a urinary tubular cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.1995.tb00012.x
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  • 6
    Digitale Medien
    Digitale Medien
    Acute renal failure secondary to rupture of the abdominal aortic aneurysm into the inferior vena cava: Report of two successfully treated cases (1997)
    Springer
    Clinical and experimental nephrology 1 (1997), S. 237-242 
    Details
    ISSN: 1437-7799
    Schlagwort(e): abdominal aortic aneurysm ; aortocaval fistula ; acute renal failure ; hepatic injury
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Aortocaval fistula is an unusual complication of an abdominal aortic aneurysm. We describe 2 patients with abdominal aortic aneurysms who presented with acute renal failure and hepatic injury secondary to spontaneous aortocaval fistulas. The fistulas were shown by computed tomography, right heart catheterization, and abdominal aortography, and were confirmed at surgery. Increases in the fractional excretion of filtered sodium, the urine sodium concentration divided by the urine-to-plasma creatinine ratio (the renal failure index), and the urine sodium concentration were observed. The patients recovered renal and hepatic function after closure of the fistulas. Increased venous pressure resulting from aortocaval shunt might cause the alteration of renal and hepatic function. Therefore, it is important to accurately diagnose the aortocaval fistula and to close it urgently by surgical methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02480702
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