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  • 1
    Electronic Resource
    Electronic Resource
    Inflammatory mediators of the terminal dentition in adult and early onset periodontitis (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 33 (1998), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Based upon the prosthodontic literature, subjects who are at the transition stage between natural dentition and edentulism are called “terminal dentition” (TD) cases. The aim of the present cross-sectional investigation was to characterize the local and systemic inflammatory responses in 2 groups of patients with terminal dentition periodontitis. Eight severe adult periodontitis terminal dentition (AP-TD) subjects and 8 early onset periodontitis terminal dentition (EOP-TD) subjects were entered into the study. Our purpose was to measure an extended battery of cytokines in the gingival crevicular fluid (GCF) and in lipopolysaccharide (LPS)-stimulated monocytic culture supernatants as well as gingival mononuclear cell messenger RNA (mRNA) transcripts determined from biopsy samples. Within the GCF there were 3 tiers (levels) of mediators based upon approximate 10-fold differences in concentration. The highest tier included prostaglandin E2 (PGE2), interleukin-1β (IL-1β) and interleukin-2 (IL-2), the intermediate tier included tumor necrosis factor alpha (TNFα) and interferon gamma (IFN-γ) and at the lowest concentration level were interleukin-4 (IL-4) and interleukin-6 (IL-6). Thus, the GCF analysis dearly indicated that in both AP-TD and EOP-TD groups the monocytic, i.e. IL-1β and PGE2 and Th1, i.e. IL-2 and IFN-γ, inflammatory mediator levels quantitatively dominated over the Th2 mediators, i.e. IL-4 and IL-6. LPS-stimulated monocytic release of IL-1β, PGE2 and TNFα was significantly elevated in both AP-TD and EOP-TD groups compared to those of a control group of 21 subjects with moderate to advanced adult periodontitis. The cytokine mRNA expression of isolated gingival mononuclear cells showed that in both the AP-TD and the EOP-TD groups Th1 and Th2 cytokines were expressed, with low levels of IL-4 and IL-12. In conclusion, our data suggest that this cross-sectional TD periodontitis model may reflect progressive periodontal disease associated with tooth loss. Furthermore, although Th1 cytokine levels in the GCF dominate over the Th2 response, monocytic activation provides the main source of proinflammatory mediators. In addition, LPS-stimulated peripheral blood monocytes demonstrate an upregulated inflammatory mediator secretion in the terminal dentition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1998.tb02193.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inflammatory mediators of the terminal dentition in adult and early onset periodontitis (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 33 (1998), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Based upon the prosthodontic literature, subjects who are at the transition stage between natural dentition and edentulism are called “terminal dentition” (TD) cases. The aim of the present cross-sectional investigation was to characterize the local and systemic inflammatory responses in 2 groups of patients with terminal dentition periodontitis. Eight severe adult periodontitis terminal dentition (AP-TD) subjects and 8 early onset periodontitis terminal dentition (EOP-TD) subjects were entered into the study. Our purpose was to measure an extended battery of cytokines in the gingival crevicular fluid (GCF) and in lipopolysaccharide (LPS)-stimulated monocytic culture supernatants as well as gingival mononuclear cell messenger RNA (mRNA) transcripts determined from biopsy samples. Within the GCF there were 3 tiers (levels) of mediators based upon approximate 10-fold differences in concentration. The highest tier included prostaglandin E2 (PGE2), interleukin-1/β (IL-1/β) and interleukin-2 (IL-2), the intermediate tier included tumor necrosis factor alpha (TNFα) and interferon gamma (IFN) and at the lowest concentration level were interleukin-4 (IL-4) and interleukin-6 (IL-6). Thus, the GCF analysis clearly indicated that in both AP-TD and EOP-TD groups the monocytic, i.e. IL-l/β and PGE2 and Thl, i.e. IL-2 and IFN-, inflammatory mediator levels quantitatively dominated over the Th2 mediators, i.e. IL-4 and IL-6. LPS-stimulated monocytic release of IL-1/β, PGE2 and TNFα was significantly elevated in both AP-TD and EOP-TD groups compared to those of a control group of 21 subjects with moderate to advanced adult periodontitis. The cytokine mRNA expression of isolated gingival mononuclear cells showed that in both the AP-TD and the EOP-TD groups Thl and Th2 cytokines were expressed, with low levels of IL-4 and IL-12. In conclusion, our data suggest that this cross-sectional TD periodontitis model may reflect progressive periodontal disease associated with tooth loss. Furthermore, although Thl cytokine levels in the GCF dominate over the Th2 response, monocytic activation provides the main source of proinflammatory mediators. In addition, LPS-stimulated peripheral blood monocytes demonstrate an upregulated inflammatory mediator secretion in the terminal dentition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1998.tb02313.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Wachstum von Kindern in Remission nach Medulloblastomtherapie Analyse der 2-Jahres-Daten unter Therapie mit Wachstumshormon*,** (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 476-480 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Kinder ; Kleinwuchs ; Medulloblastomtherapie ; Spätfolgen ; Wachstumshormontherapie ; Key words Children ; Growth hormone therapy ; Late effects ; Medulloblastomatherapy ; Short stature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aim: Growth hormone deficiency is a major long-term side effect of therapy in children with medulloblastoma. The aim of our analysis was to find out if growth hormone therapy is as effective in children after medulloblastoma therapy as in children treated for idiopathic growth hormone deficiency. Methods: We analysed 2 years auxological data of 6 children after medulloblastoma therapy who were in remission for at least 2 years. The data were compared to those of 8 children with idiopathic growth hormone deficiency. Results: Growth velocity (cm/year) in the medulloblastoma group improved significantly from 3.8 (before therapy start) to 8.4 (1. year) and to 7.4 (2. year). The height standard deviation score for chronological age improved from −2.9 at start to −2.0 after 2 years treatment. Conclusion: After 2 years growth hormone treatment growth was as a good in patients after medulloblastoma therapy as in patients treated for idiopathic growth hormone deficiency.
    Notes: Zusammenfassung Fragestellung: Eine der wichtigsten Langzeitnebenwirkungen der Medulloblastomtherapie bei Kindern ist ein Wachstumshormonmangel. Es stellt sich die Frage, ob eine Wachstumshormontherapie bei Medulloblastompatienten genauso effektiv ist wie bei Kindern mit idiopathischem Wachstumshormonmangel. Methode: Wir analysierten die 2 Jahres-Wachstumsdaten von 6 Medulloblastomkindern, die mindestens 2 Jahre in Remission waren und verglichen sie mit den Daten von 8 Kindern mit idiopathischem Wachstumshormonmangel. Ergebnisse: Nach Beginn der Wachstumshormontherapie verbesserte sich die Wachstumsgeschwindigkeit (cm/Jahr) bei den Medulloblastompatienten von 3,8 signifikant auf 8,4 (1. Jahr) und 7,4 im 2. Therapiejahr. Die Abweichung der Körperhöhe von der Norm (SDS) in Relation zum chronologischen Alter verbesserte sich von −2,9 (Start) auf −2,0 (2 Jahre). Schlußfolgerung: Bei der Analyse der 2-Jahres-Daten zeigte sich in der Medulloblastomgruppe ein ebenso gutes Wachstum unter Wachstumshormon wie in der Gruppe mit idiopathischem Wachstumshormonmangel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050288
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  • 4
    Electronic Resource
    Electronic Resource
    Continuous plasma resin perfusion for detoxification of methotrexate (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 533-536 
    Details
    ISSN: 1432-1076
    Keywords: Key words Methotrexate ; Acute renal failure ; Haemodiafiltration ; Plasma adsorption ; Ion-exchange resins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred. Conclusion The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050656
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  • 5
    Electronic Resource
    Electronic Resource
    Neurophysiological findings in long-term survivors of acute lymphoblastic leukaemia in childhood treated with the BFM protocol 81 SR-A/B (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 727-733 
    Details
    ISSN: 1432-1076
    Keywords: Key words Acute lymphoblastic leukaemia ; Neurophysiology ; CNS late effects ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monitoring of therapy-related late effects after acute lymphoblastic leukaemia (ALL) therapy in childhood has become an increasingly important field in posttherapeutic patient surveillance. The usefulness of neurophysiological investigations (e.g. EEG, evoked potentials (EP)) as part of these attempts is controversial. The present report focuses on this problem and the question whether and to what extent routinely performed EEG recordings and visual evoked potentials (VEP) were correlated with further measures of CNS integrity. EEGs and VEPs were recorded in 163 asymptomatic long-term survivors of ALL in childhood during a large retrospective multicentre study evaluating CNS late sequelae following antileukaemic therapy. Fifty-two ALL long-term survivors (4.5–10.6 years after end of therapy, median: 8.8 years), who had been treated according to BFM-81 SR-A (n=30) or SR-B (n=22) were selected for this analysis focusing on therapy-related CNS late effects. Therapy protocols differed with regard to the mode for CNS prophylaxis: SR-A, cranial irradiation with intrathecal methotrexate; SR-B, intrathecal and iv methotrexate. Neurophysiological findings were correlated with illness- and treatment-related parameters, as well as with data on the morphological, neurological and psychological status of the CNS. At the time of follow-up neurophysiological measures were abnormal in 28/52 cases (53.8%). Neither illness- nor therapy-specific differences in CNS prophylaxis showed any relationship to EEG/VEP outcome any relationship to EEG/VEP outcome in this reduced group of the whole study population. Children with EEG/VEP abnormalities showed a significantly higher incidence of structural CNS disturbances compared to those with inconspicuous neurophysiological recordings (60.9% vs 31.8%). However, in this special subject group there was no specific neurophysiological finding for a specific morphological substrate, neurological or psychological deficiency and vice versa. Conclusion Routinely performed EEG/VEP investi gations are not very helpful measures to predict the presence or degree of behavioural deficiencies, neuro‐logical disturbances, or morphological CNS abnor‐malities. Patients who received cranial irradiation or systemic methotrexate applications showed the same incidence of neurophysiological disturbances without evidence for specific neurotoxic correlates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050700
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    Paper (German National Licenses)
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