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  • 1
    Electronic Resource
    Electronic Resource
    A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3′ third of the gene (1998)
    Springer
    Human genetics 〈Berlin〉 103 (1998), S. 154-161 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have analyzed 61 German breast and breast/ovarian cancer families for BRCA1 mutations using single-strand conformation polymorphism analysis (SSCP) followed by sequencing. Forty-seven of the families had at least three cases (at least two under 60 years) and 14 families had only two cases of breast/ovarian cancer (at least one under 50 years). Twenty-eight families were breast/ovarian and 33 were breast cancer-only families. Eighteen mutations in BRCA1 were detected in 11/28 breast/ovarian cancer families and 7/33 breast cancer families and none in the families with only two cases. We identified 17 truncation mutations (8 frameshift, 7 nonsense and 2 splice variants) and one missense mutation. Seven of these are novel and two, the 5382insC and 5622C→T mutations, occurred in two apparently unrelated families. The genotype of the two families with the 5382insC mutation is compatible with the rare haplotype segregating with the 5382insC mutation in different populations, further supporting its European origin. One unclassified missense alteration, R841W, was found in one family but did not segregate with the disease, suggesting that it is more likely a polymorphism. We also report and discuss the sequence of several new unclassified single-nucleotide changes first identified by SSCP. Of the 18 mutations, 13 occurred in the 3′ third of the gene (end of exon 11–24) and ovarian cancers were found in eight of these families.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050799
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Breast cancer risk assessment: use of complete pedigree information and the effect of misspecified ages at diagnosis of affected relatives (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 348-356 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050704
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Modifying effect of reproductive risk factors on the age at onset of breast cancer for GermanBRCA1 mutation carriers (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 272-279 
    Details
    ISSN: 1432-1335
    Keywords: Breast cancer ; Genetic susceptibility ; Modifying factors ; Survival analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Female carriers of mutations in theBRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their life-time. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at onset of disease. We identified individuals showing a high probability of linkage toBRCA1 and examined the effect of other known risk factors on disease risk. A total of 43 families with at least three breast or ovarian cancer cases, including two affected before 60 years of age, were studied for linkage to the susceptibility locusBRCA1. Blood samples from relevant family members were used to genotype for at least three chromosome 17q polymorphic markers. Information on reproductive history, hormone use and lifestyle factors was collected from female members using a self-administered questionnaire. Diagnoses of breast and ovarian cancer were verified through pathology reports and paraffin blocks were obtained when available. Multipoint LOD (logarithm of the odds) scores were calculated and individuals from 10 families with a posteriori probability for linkage greater than 0.90 were used for further analysis. Forty-sixBRCA1 carriers were identified by the disease haplotype; 30 were affected with breast cancer and 5 with ovarian cancer. Proportional-hazards analysis of age at onset of breast cancer yielded increased relative risks of 1.74 for early age at menarche (〈14 years), 1.58 for late age at first birth (≥25 years) or nulliparity, and 2.78 for recent year of birth (≥1940); however, none of the risk estimates was statistically significant. When both breast and ovarian cancer were considered as disease endpoints, the birth cohort effect was stronger and age at first birth showed no effect. Our data provide some evidence that reproductive risk factors for breast cancer have an effect on age at onset forBRCA1 carriers. However, considering that our analyses were based on limited numbers, these results warrant further clarification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208638
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers (1997)
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 272-279 
    Details
    ISSN: 1432-1335
    Keywords: Key words Breast cancer  ;  Genetic susceptibility  ;  Modifying factors  ;  Survival analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at onset of disease. We identified individuals showing a high probability of linkage to BRCA1 and examined the effect of other known risk factors on disease risk. A total of 43 families with at least three breast or ovarian cancer cases, including two affected before 60 years of age, were studied for linkage to the susceptibility locus BRCA1. Blood samples from relevant family members were used to genotype for at least three chromosome 17q polymorphic markers. Information on reproductive history, hormone use and lifestyle factors was collected from female members using a self-administered questionnaire. Diagnoses of breast and ovarian cancer were verified through pathology reports and paraffin blocks were obtained when available. Multipoint LOD (logarithm of the odds) scores were calculated and individuals from 10 families with a posteriori probability for linkage greater than 0.90 were used for further analysis. Forty-six BRCA1 carriers were identified by the disease haplotype; 30 were affected with breast cancer and 5 with ovarian cancer. Proportional- hazards analysis of age at onset of breast cancer yielded increased relative risks of 1.74 for early age at menarche (〈14 years), 1.58 for late age at first birth ( ≥ 25 years) or nulliparity, and 2.78 for recent year of birth ( ≥ 1940); however, none of the risk estimates was statistically significant. When both breast and ovarian cancer were considered as disease endpoints, the birth cohort effect was stronger and age at first birth showed no effect. Our data provide some evidence that reproductive risk factors for breast cancer have an effect on age at onset for BRCA1 carriers. However, considering that our analyses were based on limited numbers, these results warrant further clarification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208638
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Lung cancer mortality among European rock/slag wool workers: exposure-response analysis (1998)
    Springer
    Cancer causes & control 9 (1998), S. 411-416 
    Details
    ISSN: 1573-7225
    Keywords: Europe ; dose-response ; lung cancer ; man-made vitreous fibers ; men ; occupation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The purpose was to analyze the relationship between semi-quantitative indices of exposure to man-made vitreous fibers and lung cancer mortality among European rock/slag wool (RSW) workers. Methods: The study population comprised 9,603 male workers employed in RSW production in seven factories in Denmark, Norway, Sweden, and Germany, followed up for mortality as of 1990-91. Estimates of past exposure to respirable fibers were used to calculate cumulative exposure with a 15-year lag and maximum annual exposure based on employment history up to 1977. Rate ratios were estimated via multivariate Poisson regression, adjusting for country, age, calendar year, time since first employment, and employment status. Results: A total of 159 lung cancer deaths were included in the analysis of which 97 among workers with more than one year of employment. We found nonstatistically significant trends in lung cancer risk according to cumulative exposure. Relative risks (RR) in the four quartiles were 1.0 (reference), 1.3 (95 percent confidence interval [CI]=0.8-2.4), 1.2 (CI=0.7-2.1), and 1.5 (CI=0.7-3.0, P test for trend=0.4). When workers with less than one year of employment were excluded, there was no increased risk; the RRs in the four quartiles were 1.0, 0.9 (CI=0.4-2.0), 0.8 (CI=0.3-1.9), and 1.0 (CI=0.4-2.7). No trend was present according to maximum annual exposure. The results were not consistent among countries. Conclusions: We found a positive association between exposure to respirable fibers and lung cancer mortality. However, the lack of statistical significance, the dependence of the results on inclusion of short-term workers, the lack of consistency among countries, and the possible correlation between exposure to respirable fibers and to other agents reduce the weight of such evidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008871718323
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Occupation and bladder cancer in European women (1999)
    Springer
    Cancer causes & control 10 (1999), S. 209-217 
    Details
    ISSN: 1573-7225
    Keywords: bladder neoplasms ; occupation ; risk factors ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: We examined the importance of occupational exposures for bladder cancer in women. Methods: We combined data from 11 case-control studies conducted between 1976 and 1996 in six European countries. The pooled data comprised 700 incident female cases and 2425 population or hospital controls, aged 30–79 years. Lifetime occupational and smoking history were examined using common coding. Results: Excess risks were found in only a few of the occupations previously identified at high risk for bladder cancer. Statistically significant excess risks were observed for metal workers, particularly blacksmiths, toolmakers and machine tool operators (OR: 2.0, 95% CI: 1.1–3.6), tobacco workers (OR: 3.1, 95% CI: 1.1–9.3), field crop and vegetable farm workers (OR: 1.8, 95% CI: 1.0–3.1), tailors and dress makers (OR: 1.4, 95% CI: 1.0–2.1), saleswomen (OR: 2.6, 95% CI: 1.0–6.9), and mail sorting clerks (OR: 4.4, 95% CI: 1.0–19.5). About 8% (95% CI: 3.1–19.9) of all bladder cancers in women could be attributed to occupation after adjusting for smoking. The attributable risk was higher in women aged less than 65 years (12%), compared to older women (4%). Conclusions: The calculation of the attributable risk on the basis of results from this analysis may have caused some overestimation of the proportion of occupational bladder cancer in women. A significant proportion, however, of bladder cancer cases among European women less than 65years is likely to be attributed to occupation. This link between bladder cancer in women and occupational factors has received little recognition, probably because studies addressing these issues have predominantly been done in men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008852127139
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    Paper (German National Licenses)
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