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  • 1
    Electronic Resource
    Electronic Resource
    The μ-Phase of Co6.3Nb6.7 (1995)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 1241-1243 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270195000552
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of weak interactions on the structure of adaptive surfaces (1997)
    Springer
    Soft computing 1 (1997), S. 148-154 
    Details
    ISSN: 1433-7479
    Keywords: Key words self-organization ; evolutionary adaptability ; adaptive surfaces ; dual dynamics model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract  The information processing and evolutionary capabilities of networks of decision making elements are strongly dependent on structural features. Weak interaction effects play an especially important role. The manner in which these are introduced controls the effect of mutation on the dynamics of the network. We report on a dual dynamics model which is being used to address this issue. The model combines discrete decision making features reflective of logical operations with arithmetic features that represent graded influences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005000050016
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  • 3
    Electronic Resource
    Electronic Resource
    Protein kinase C β from Friend erythroleukemia cells is associated with chromatin and DNA (1995)
    Springer
    Molecular and cellular biochemistry 151 (1995), S. 107-111 
    Details
    ISSN: 1573-4919
    Keywords: protein kinase C ; DNA-binding protein ; erythroleukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Certain protein kinase C (PKC) isotypes are localized to the nucleus during cellular proliferation in murine erythroid cells, as well as in human promyelocytic leukemia and erythroleukemia cells. Because the structure of these PKC isotypes contains a conserved cysteine-rich region that contains the zinc finger DNA binding motif, we tested the hypothesis that selected PKC isotypes found in Friend erythroleukemia cells can bind to DNA. Cell lysates from murine Friend erythroleukemia cells, which express α, βI, and βII PKC, expressed greater amounts of the β isoforms than the α isoform of PKC in their nuclei, and PKC βI was found in the chromatin of these cells. Lysates of these cells were tested for their ability to bind to a DNA-cellulose columm. Bound proteins were eluted with a step gradient of increasing KCl concentrations, and eluant fractions were then subjected to immunoblot analysis using isotype-specific antibodies to the α and βI isotypes of PKC. DNA binding was detected for the PKC βI isotype, which is present in the nucleus, but not for the more abundant PKC α isotype, which resides primarily in the cytoplasm. These results demonstrate that PKC can associate with DNA, and that this association is isotype specific in Friend erythroleukemia cells. (Mol Cell Biochem151: 107–111, 1995)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01322332
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  • 4
    Electronic Resource
    Electronic Resource
    Betaxolol in Anxiety Disorders (1998)
    Springer
    Annals of clinical psychiatry 10 (1998), S. 9-14 
    Details
    ISSN: 1573-3238
    Keywords: Anxiety ; panic ; betaxolol ; β-blocker ; treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Betaxolol, a long-acting β-adrenergic blocker that enters the central nervous system, was examined for therapeutic effects on the persistent anxiety of anxiety disorders. Prior studies of β-blockers examined only agents that were short-acting or did not enter the brain. Betaxolol was administered to 31 patients in open trials. Of 13 outpatients, 11 had generalized anxiety disorder (GAD) and 2 had adjustment disorder with anxiety. Five with GAD had concurrent panic disorder. Of 18 inpatients, 16 had GAD and 2 had adjustment disorder with anxiety. Betaxolol doses were increased until the patient responded or declined further dosage. Severity was rated on a 4-point global scale. Before betaxolol, all were moderately or severely ill. In all patients with panic disorder panic attacks stopped within 2 days (p〈0.001). Anxiety decreased to no more than marginally ill in 85% of outpatients (p〈0.0001) and all inpatients (p〈0.0001). Betaxolol doses were usually 5 mg once or twice daily; four inpatients took 10 to 20 mg twice daily. In sum, betaxolol administration was rapidly followed by improvements that were easily noticed by the doctor, even in patients with longstanding anxiety and obsessive–compulsive personality disorder. Preliminary observations in posttraumatic stress disorder are similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026146528290
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  • 5
    Electronic Resource
    Electronic Resource
    Biosynthesis of the endogenous cyclic adenosine monophosphate (AMP) antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), from prostaglandin E and activated inositol polyphosphate in rat liver plasma membranes (1996)
    Springer
    Acta diabetologica 33 (1996), S. 126-138 
    Details
    ISSN: 1432-5233
    Keywords: Key words  Prostaglandin E ; Insulin action ; Prostaglandylinositol cyclic phosphate ; Activated inositol polyphosphate ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   The endogenous cyclic adenosine monophosphate (AMP) antagonist, cyclic PIP, has been identified as a prostaglandylinositol cyclic phosphate. It inhibits protein kinase A 100% and activates protein serine phosphatase about sevenfold. It is biosynthesized by an enzyme of the plasma membrane when the assay mixture contains adenosine triphosphate (ATP), Mg2+, prostaglandin E and a novel inositol polyphosphate, which cannot be substituted by commercially available inositol phosphates. This novel inositol polyphosphate is a very labile compound. On anion exchange chromatography it elutes in the range of ATP, which may indicate the presence of three phosphate groups. It adsorbs on charcoal, which suggests the presence of a hydrophobic component, possibly a guanosine. Pyrophosphates obtained from inositol 1,4- and inositol 2,4-bisphosphate are accepted by cyclic PIP synthetase for the synthesis of cyclic PIP. The biosynthesis is characterized by enzyme kinetic parameters like dependence on time, enzyme and substrate concentration. The pH optimum of the enzyme is in the range 7.5–8. The enzyme functions optimally with prostaglandin E and poorly with prostaglandin A as the substrate. The presence of fluoride in the assay causes a three- to fourfold increase in cyclic PIP synthesis, which may be correlated with activation via G proteins. These data support previous reports on the chemical structure and action of cyclic PIP. With respect to the possible isomers of cyclic PIP, these indicate that it is most likely the C4-hydroxyl group of the inositol which binds the C15-hydroxyl group of prostaglandin E. A model of hormone-stimulated synthesis of cyclic PIP is proposed: phospholipase A2 and phospholipase C, activated by G proteins upon α-adrenergic stimulation, liberate either unsaturated fatty acids or inositol phosphates, which are transformed to prostaglandins and to novel inositol polyphosphate with an energy-rich bond. The cyclic PIP synthetase combines these two substrates to cyclic PIP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569423
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  • 6
    Electronic Resource
    Electronic Resource
    Biosynthesis of the endogenous cyclic adenosine monophosphate (AMP) antagonist, prostaglandylinositol cyclic phosphate (cyclic PIP), from prostaglandin E and activated inositol polyphosphate in rat liver plasma membranes (1996)
    Springer
    Acta diabetologica 33 (1996), S. 126-138 
    Details
    ISSN: 1432-5233
    Keywords: Prostaglandin E ; Insulin action ; Prostaglandylinositol cyclic phosphate ; Activated inositol polyphosphate ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The endogenous cyclic adenosine monophosphate (AMP) antagonist, cyclic PIP, has been identified as a prostaglandylinositol cyclic phosphate. It inhibits protein kinase A 100% and activates protein serine phosphatase about sevenfold. It is biosynthesized by an enzyme of the plasma membrane when the assay mixture contains adenosine triphosphate (ATP), Mg2+, prostaglandin E and a novel inositol polyphosphate, which cannot be substituted by commercially available inositol phosphates. This novel inositol polyphosphate is a very labile compound. On anion exchange chromatography it elutes in the range of ATP, which may indicate the presence of three phosphate groups. It adsorbs on charcoal, which suggests the presence of a hydrophobic component, possibly a guanosine. Pyrophosphates obtained from inositol 1,4- and inositol 2,4-bisphosphate are accepted by cyclic PIP synthetase for the synthesis of cyclic PIP. The biosynthesis is characterized by enzyme kinetic parameters like dependence on time, enzyme and substrate concentration. The pH optimum of the enzyme is in the range 7.5–8. The enzyme functions optimally with prostaglandin E and poorly with prostaglandin A as the substrate. The presence of fluoride in the assay causes a three- to fourfold increase in cyclic PIP synthesis, which may be correlated with activation via G proteins. These data support previous reports on the chemical structure and action of cyclic PIP. With respect to the possible isomers of cyclic PIP, these indicate that it is most likely the C4-hydroxyl group of the inositol which binds the C15-hydroxyl group of prostaglandin E. A model of hormone-stimulated synthesis of cyclic PIP is proposed: phospholipase A2 and phospholipase C, activated by G proteins upon α-adrenergic stimulation, liberate either unsaturated fatty acids or inositol phosphates, which are transformed to prostaglandins and to novel inositol polyphosphate with an energy-rich bond. The cyclic PIP synthetase combines these two substrates to cyclic PIP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569423
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  • 7
    Electronic Resource
    Electronic Resource
    Melancholia with Onset During Treatment With SRISs (1998)
    Springer
    Annals of clinical psychiatry 10 (1998), S. 177-179 
    Details
    ISSN: 1573-3238
    Keywords: Melancholia ; major depression ; tricyclics ; SSRIs ; bupropion ; treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A defined group of medical records was surveyed for patients who showed onset of major depression with melancholic features while taking an antidepressant medication. Nine cases resulted. In all the antidepressants being taken while melancholia began were SSRIs and the melancholic depression remitted rapidly with the first treatment given, bupropion in five males, nortriptyline with triiodothyronine in two females, and ECT in one male and one female. This suggests that patients who take SSRIs and are melancholic respond well to bupropion, nortriptyline, or ECT These observations complement reports of low responsivity of melancholic depression to SSRIs and distinctions between melancholic and nonmelancholic depressions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022398213729
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  • 8
    Electronic Resource
    Electronic Resource
    Ta5Se1.2Te1.8 - eine tetraedrisch dicht gepackte metallreiche SchichtstrukturProfessor Joachim Strähle zum 60. Geburtstag gewidmet (1997)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 623 (1997), S. 742-748 
    Details
    ISSN: 0044-2313
    Keywords: Tantalum-rich chalcogenides ; selenides ; tellurides ; high temperature synthesis ; crystal structure ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Ta5Se1.2Te1.8 - a Tetrahedrally Close-packed Metal-rich Layer StructureTa5Se1.2Te1.8 was prepared by reducing a mixture of TaSe2 and TaTe2 with tantalum at 1540°C. A X-ray single crystal structure analysis was performed. Space group; P1, a = 1008.5(4) pm, b = 1052.1(4) pm, c = 1440,2(5) pm, α = 90.32(2)°, β = 96.42(2)°, γ = 108.28(2), Z = 8, Pearson-Symbol; aP64, 5684 reflexions, 300 variables, RI = 0.066. The structure is built up of hetero-nuclear, distorted icosahedral clusters penetrating mutually into pentagonal anti-prismatic columns. The connection of these units by inter-columnar Ta-Ta- and Ta-Se, Te-contacts affords tetrahedral close-packed layers. The chalcogen atoms are one-sidedly coordinated by three, four or six tantalum atoms.
    Notes: Ta5Se1.2Te1.8 wurde aus einem Gemenge aus TaSe2 und TaTe2 durch Reduktion mit Tantal bei 1540°C dargestellt. Die Struktur wurde aus Röntgenbeugungsintensitäten eines Einkristalls aufgeklärt. Raumgruppe: P1, a = 1008,5(4) pm, b = 1052,1(4) pm, c = 1440,2(5) pm, α = 90,32(2)°, β = 96,42(2)°, γ = 108,28(2), Z = 8, Pearson-Symbol: aP64, 5684 Reflexe, 300 Variablen, RI = 0,066. Die Struktur besteht aus zentrierten, verzerrt ikosaedrischen, heteronuklearen Clustern, die sich zu Strängen durchdringen. Die pentagonal-antiprismatischen Stränge sind untereinander über interkolumnare Ta-Ta- und Ta-Se, Te-Kontakte zu tetraedrisch dicht gepackten Schichten verknüpft. Die Chalkogen-Atome sind stels einseitig drei-, vier-, oder sechsfach von Tantal-Atomen koordiniert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.199762301117
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