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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— A study of the dependence of the fracture toughness on the microstructural morphology of polycrystalline materials is presented. The microstructure of several aluminas was characterized by thermal etching and image analysis. The fracture toughness of these materials was then determined by bridge-indentation pre-cracking followed by a four-point bending test procedure. A SEM investigation of the mechanisms of crack propagation was also carried out. The observed microstructure-related fracture toughness responses are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Crystals of alcohol dehydrogenase from Sulfolobus solfataricus were grown in the Advanced Protein Crystallization Facility during the Life and Microgravity Sciences Spacelab mission on the US Space Shuttle. Large diffracting crystals were obtained by dialysis, whereas only poor-quality crystals were obtained by vapour diffusion. The quality of both the microgravity and ground-based crystals was analysed by X-ray diffraction. There was some improvement in terms of size and diffraction resolution limit for the microgravity crystals. However, the twinning observed in the Earth-grown crystals was also present for those grown in microgravity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of engineering geology and the environment 57 (1998), S. 41-50 
    ISSN: 1435-9537
    Keywords: Key words Pumice ; Vesuvius ; Density ; Porosity ; Landslides ; Stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Resumé Cet article décrit les caractéristiques des sols constitués de ponces dans la région du Vésuve et discute les différents essais concernant le comportement de ces sols vis-à-vis de l'eau dans un certain nombre de sites différents. L'attention est attirée sur la présence de vides inter aussi bien qu'intraparticulaires et les auteurs proposent des modifications du diagramme traditionnel des phases solide-eau-air pour tenir compte de ces phénomènes. L'importance d'une bonne compréhension de la structure de ces sols et de leur comportement vis-à-vis des circulations d'eau est illustrée a l'aide d'exemples de glissements et de travaux de confortement.
    Notes: Abstract  This paper describes the characteristics of pumice soils from the area of Mount Vesuvius and discusses sinking, watering and other geotechnical tests on pumice from a number of sites. Attention is drawn to the presence of both inter- and intra-particle voids within this material and appropriate modifications to the standard solid-water-air phase diagram are suggested to take account of this. The importance of understanding the structure of the pumice and its response to rainfall/ground water conditions is discussed in relation to both landslips and stabilisation works.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Key words Antigen presentation ; TAP peptide transporter gene ; HLA class II ; insulin-dependent diabetes mellitus ; linkage disequilibrium.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The TAP2 gene, located in the HLA class II region, encodes a subunit of a transporter involved in the endogenous antigen-processing pathway, and has been suggested to contribute to the genetic risk for insulin-dependent diabetes (IDDM). In order to determine whether the TAP2 locus modulates the risk conferred by HLA DQ loci, HLA DQA1-DQB1-TAP2 haplotypes were analysed in 48 IDDM probands, their first degree relatives, and in 62 normal control subjects. A decreased frequency of the TAP2B allele was confirmed in this IDDM cohort (12 vs 28 % in control subjects, p c 〈 0.05). Analysis of 73 informative meiotic events in IDDM and control families demonstrated a recombination fraction between HLA DQB1 and TAP2 loci of 0.041 (Log of the odds score = 16.5; p 〈 10–8) indicating strong linkage between these loci. Family haplotype analysis demonstrated linkage disequilibrium between TAP2 and HLA DQA1-DQB1, and showed that the reduced frequency of TAP2B was associated with its absence on the IDDM susceptible DQA1*0301-DQB1*0302 haplotype, its low frequency on DQA1*0501-DQB1*0201, and the association of TAP2B with DQA1*0101-DQB1*0501 haplotypes which were less frequent in IDDM patients. Comparison of transmitted with non-transmitted haplotypes in IDDM families showed a slight but not significant decrease in TAP2B allele frequency on transmitted (3 of 37) vs non-transmitted (2 of 9) HLA DQA1*0501-DQB1*0201 haplotypes. No other differences were observed. Twenty-four unrelated DQA1*0501-DQB1*0201 haplotypes from non-diabetic families had a TAP2B allele frequency (4 %) similar to that in IDDM haplotypes. These findings suggest that the decreased TAP2B allele frequency in Italian IDDM patients is due to HLA DQ haplotype differences between IDDM patients and control subjects, and do not support a contribution to IDDM risk by the TAP2 locus. [Diabetologia (1995) 38: 968–974]
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Antigen presentation ; TAP peptide transporter gene ; HLA class II ; insulin-dependent diabetes mellitus ; linkage disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The TAP2 gene, located in the HLA class II region, encodes a subunit of a transporter involved in the endogenous antigen-processing pathway, and has been suggested to contribute to the genetic risk for insulin-dependent diabetes (IDDM). In order to determine whether the TAP2 locus modulates the risk conferred by HLA DQ loci, HLA DQA1-DQB1-TAP2 haplotypes were analysed in 48 IDDM probands, their first degree relatives, and in 62 normal control subjects. A decreased frequency of the TAP2B allele was confirmed in this IDDM cohort (12 vs 28% in control subjects, p c 〈0.05). Analysis of 73 informative meiotic events in IDDM and control families demonstrated a recombination fraction between HLA DQB1 and TAP2 loci of 0.041 (Log of the odds score=16.5; p〈10−8) indicating strong linkage between these loci. Family haplotype analysis demonstrated linkage disequilibrium between TAP2 and HLA DQA1-DQB1, and showed that the reduced frequency of TAP2B was associated with its absence on the IDDM susceptible DQA1*0301-DQB1*0302 haplotype, its low frequency on DQA1*0501-DQB1*0201, and the association of TAP2B with DQA1*0101-DQB1*0501 haplotypes which were less frequent in IDDM patients. Comparison of transmitted with non-transmitted haplotypes in IDDM families showed a slight but not significant decrease in TAP2B allele frequency on transmitted (3 of 37) vs non-transmitted (2 of 9) HLA DQA1*0501-DQB1*0201 haplotypes. No other differences were observed. Twenty-four unrelated DQA1*0501-DQB1*0201 haplotypes from non-diabetic families had a TAP2B allele frequency (4%) similar to that in IDDM haplotypes. These findings suggest that the decreased TAP2B allele frequency in Italian IDDM patients is due to HLA DQ haplotype differences between IDDM patients and control subjects, and do not support a contribution to IDDM risk by the TAP2 locus.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Photothermal reflectance microscopy was applied to the analysis of local thermal diffusivity on tape-cast AlN ceramics. The materials were obtained from three different commercial powders, two sintering temperatures (1750 and 1800 °C), and 3 wt % Y2O3 sintering aid. Owing to the high spatial resolution of the technique (∼30 μm in the present case), measurements in different positions on the sample surface were carried out. In this way a study of the homogeneity of thermal properties was performed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 33 (1998), S. 1827-1836 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A solid state bonding technique under hot pressing was used for joining alumina with thin metal sheets of Ni, Cu and Fe. The microstructure and microchemistry of the ceramic–metal interface and of the fracture interface were examined using scanning electron microscopy (SEM) energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD), in order to identify the adhesion mechanisms and the nature of strength limiting flaws. Interaction between the selected metals and alumina can be physical or physico-chemical in nature: very low amounts of interfacial compounds were formed, depending on the processing conditions and on the presence of oxygen in the system. Fracture and toughness tests indicated that high ceramic–metal interface strengths (up to 177 MPa) were achieved under the adopted processing conditions and that strength and toughness were directly related. Moreover, an increase in hardening in the metal interlayer at a distance of 2–3 μm from the interface was observed in the samples with high strength values. The mechanical behaviour was related to several factors that strongly depend on the bonding conditions: plastic deformation of the metal, metal creep, metal intrusion and diffusion into alumina, and chemical reactions at the interface. © 1998 Chapman & Hall
    Type of Medium: Electronic Resource
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