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  • 1
    Electronic Resource
    Electronic Resource
    Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus (1996)
    Springer
    Acta diabetologica 33 (1996), S. 103-107 
    Details
    ISSN: 1432-5233
    Keywords: Anti-myeloperoxidase antibody ; Polymorphonuclear leucocytes ; Endothelial cell ; Intercellular adhesion molecule 1 (ICAM-1)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the occurrence of anti-MPO and anti-thyroperoxidase antibodies. Levels of soluble intercellular adhesion molecule 1 (ICAM-1) were found to be higher in anti-MPO antibodypositive (n=28, 508±126 ng/ml) than in anti-MPO antibody-negative (n=58, 438±140 ng/ml;P〈0.05) patients. A state of chronic neutrophil activation has been described in diabetes mellitus. As anti-MPO antibodies can stimulate neutrophils to damage endothelial cells in systemic vasculitis, this suggests that a similar mechanism may be operative in the development of diabetic angiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569418
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus (1996)
    Springer
    Acta diabetologica 33 (1996), S. 103-107 
    Details
    ISSN: 1432-5233
    Keywords: Key words  Anti-myeloperoxidase antibody ; Polymorphonuclear leucocytes ; Endothelial cell ; Intercellular adhesion molecule 1 (ICAM-1)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the occurrence of anti-MPO and anti-thyroperoxidase antibodies. Levels of soluble intercellular adhesion molecule 1 (ICAM-1) were found to be higher in anti-MPO antibody-positive (n=28, 508±126 ng/ml) than in anti-MPO antibody-negative (n=58, 438±140 ng/ml; P〈0.05) patients. A state of chronic neutrophil activation has been described in diabetes mellitus. As anti-MPO antibodies can stimulate neutrophils to damage endothelial cells in systemic vasculitis, this suggests that a similar mechanism may be operative in the development of diabetic angiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569418
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Anti-single-stranded DNA antibody in the sera of patients with type 2 diabetes mellitus (1997)
    Springer
    Acta diabetologica 34 (1997), S. 39-41 
    Details
    ISSN: 1432-5233
    Keywords: Key words Anti-single-stranded DNA antibodies ; Type 2 diabetes ; Vascular complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anti-single-stranded(ss)DNA antibodies were searched for by enzyme-linked immunosorbent assay (ELISA) in the serum of 202 outpatients with non-insulin-dependent diabetes mellitus and 135 healthy subjects to investigate their prevalence in the serum of patients with type 2 diabetes and their relationship with the presence of vascular complications. Of the 202 patients 128 had vascular complications. Anti-ssDNA antibodies were observed to be significantly more frequent in the serum of patients with vascular complications (33.6%) and in particular in patients with overt nephropathy (50%) than in patients without complications (6.7%) or controls (6.7%). Anti-ssDNA antibodies have been previously described in patients with type 1 diabetes before clinical evidence of vascular disease, and their cross-reactivity with a variety of anionic biological molecules or cells, i.e. platelets and endothelial cells, assessed. It seems not unreasonable that these autoantibodies detected in patients with type 2 diabetes could be of importance in the pathogenesis or progression of angiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050063
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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