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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 751-753 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Globular clusters, the most ancient stellar groups in our galaxy, are known to contain bright X-ray sources, faint X-ray sources and millisecond pulsars. The bright X-ray sources are neutron stars accreting matter from a companion star, and the millisecond pulsars are believed to be descendants ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 23 (1998), S. 1125-1132 
    ISSN: 1573-6903
    Keywords: Human brain capillary endothelium ; endothelin-1 ; K+ efflux ; K+ uptake ; Ca2+ uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report describes K+ efflux, K+ and Ca2+ uptake responses to endothelins (ET-1 and ET-3) in cultured endothelium derived from capillaries of human brain (HBEC). ET-1 dose dependently increased K+ efflux, K+ and Ca2+ uptake in these cells. ET-1 stimulated K+ efflux occurred prior to that of K+ uptake. ET-3 was ineffective. The main contributor to the ET-1 induced K+ uptake was ouabain but not bumetanide-sensitive (Na+-K+-ATPase and Na+-K+-Cl− cotransport activity, respectively). All tested paradigms of ET-1 effects in HBEC were inhibited by selective antagonist of ETA but not ETB receptors and inhibitors of phospholipase C and receptor-operated Ca2+ channels. Activation of protein kinase C (PKC) decreased whereas inhibition of PKC increased the ET-1 stimulated K+ efflux, K+ and Ca2+ uptake in HBEC. The results indicate that ET-1 affects the HBEC ionic transport systems through activation of ETA receptors linked to PLC and modulated by intracellular Ca2+ mobilization and PKC.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1572-946X
    Keywords: Instruments ; Gamma-ray bursts ; X-ray emission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The High-Energy Transient Experiment (HETE) is designed for the multiwavelengths study of Gamma-Ray Bursts (GRBs) in UV, X-ray and gamma-ray range with three scientific instruments. The X-ray instrument, Wide-field X-ray Monitor (WXM), consists of four units of one-dimensional position sensitive gas proportional counters and two perpendicularly oriented one-dimensional coded apertures. The WXM has a wide FOV of 1.5 steradian together with the capability to locate GRBs with ∼ 10 arcmin accuracy, and covers photon energies of 2 to 25 keV with an energy resolution of typically ∼ 18 % at 6 keV, measuring wide band spectra together with the gamma-ray spectrometer (FREGATE). The coded X-ray image will be deconvolved on board and the GRB location will be provided to the UV camera within ∼ 1 sec . GRB locations will also be broadcast in “real time” to ground-based observers for follow-up observations.
    Type of Medium: Electronic Resource
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