ISSN:
1573-8221
Keywords:
erythrocytes
;
calcium-activated potassium channels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of inhibitors of calmodulin and protein kinase C, complex [AlF4]−, and potassium channel blockers on the parameters of calcium-induced hyperpolarization in human erythrocytes is studied by recording proton distribution between the cytoplasm and incubation medium in the presence of a protonophore. It is shown that the calmodulin inhibitor dis-C3-5, the protein kinase C inhibitor staurosporine, and the blocker of highconductance calcium-activated potassium channels considerably suppress the calciuminduced hyperpolarization in erythrocytes. High concentration of [AlF4]− in the incubation medium inhibits hyperpolarization.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02458079
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