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  • 1
    Electronic Resource
    Electronic Resource
    A new type of multiparticle imaging detector (1990)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 945-952 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The foil-induced dissociation of molecular ions can provide a direct image of the stereochemical structures of small molecules. Such experiments require high-resolution measurements of the relative momenta of all dissociation fragments. In order to improve and extend previous studies of this type to a larger variety of molecules and clusters, we have developed a new type of low-pressure multiwire proportional counter. The novel feature of this large-area (25×50 cm2 ) multiparticle detector is that all the signals are recorded from a single two-level printed circuit board which serves as the anode. This segmented anode consists of three families of nonintersecting "wires'' which are interwoven on the rear surface of the board. By redundantly determining positions and arrival times, the new segmented anode multiparticle detector provides good time resolution (100–200 ps) and high spatial resolution (0.2 mm) for detecting as many as six simultaneous particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1141447
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  • 2
    Electronic Resource
    Electronic Resource
    Intersubband absorption in a modulation-doped Ga0.47In0.53As/Al0.48In0.52As multiple quantum well structure (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 571-573 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We observe strong intersubband absorption at a wavelength of 8.4 μm in an n-type modulation-doped Ga0.47In0.53As/Al0.48In0.52As multiple quantum well structure with a well thickness of 8.2 nm. An oscillator strength of the corresponding dipole transition of 21.0 is measured. The dependence of the intersubband absorption on the polarization of the incident light and on lattice temperature is investigated in detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99860
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  • 3
    Electronic Resource
    Electronic Resource
    New hydroxyisoflavans as contact sensitizers in cocus wood Brya ebenus DC (Fabaceae) (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 25 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 15-year-old girl developed perioral dermatitis and swelling of the lips, having played a flute made of cocus wood for 2 years. Patch tests with wood shavings, as well as with subsequently isolated constituents named focus 1 and focus II. were Strongly positive. Alter complete purification, boltContact allergens were identified as isoflavan derivatives, While Cocus 1 was shown to be 7,8-dihydroxy-2,4,5trmethoxyisoflava, the structure of focus II could not be elucidated exactly. It could have been Either 7,8,3′-trihydroxy 2,4 dimethoxyisoflavan or 7,8,2-trihydroxy-3′,4-dime-thoxyoflavan The exact position of the hydroxy and methoxy group in C-2 and C-3 can be determined only by complete synthesis Of both compounds or by isolation of greater amounts of focus II for further oxidation experiments. Due t0 the stronger patch lest reaction and the higher yield cocus I in the wood, this hydroxyisoflavan must be recognized as the main contact allergen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01820.x
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  • 4
    Electronic Resource
    Electronic Resource
    Contact allergy due to colophony (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 20 (1989), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 7 resin acids, 3 symbolically prepared derivatives and the neutral fraction of Chinese colophony were studied by experimental sensitization using a modified FCA method. 4 resin acids, laevopimaric. abietic. podocarpic and tetrahydroabietic. proved to be weak sensitizers Neoabietic, dehydroabietic, isopimarie acid and larixol remained negative. However, the derivative, methyl abietate and calcium abietate. were shown to be moderate sensitizers. and the maleic-modified adduct to be a moderate to strong sensitizer. As laevopimaric acid plays only a minor rote in colophony, abietic acid must he considered a major, even if weak, allergen in non-modified colophony. The neutral fraction of colophony is also partially involved in colophony allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1989.tb03094.x
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  • 5
    Electronic Resource
    Electronic Resource
    Release and Functional Characterization of the Leukotriene D4-Metabolizing Enzyme (Dipeptidase) from Human Polymorphonuclear Leucocytes (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 25 (1987), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Polymorphonuclear leucocytes released LTD4-dipeptidase activity in a time-, calcium-, and cell number-dependent fashion. The LTD4-dipeptidase released from polymorphonuclear leucocytes (PMN) by incubation with calcium (0.91 mm) was detectable up to a cell concentration of 1 × 106/ml and increased with higher concentrations. Maximal LTD4-dipeptidase activity within the extracellular environment was detected after 15 min of incubation (2x107/ml) in the presence of 2–4.5 mm calcium or after 30 min, when stimulation was carried out with 0.91 mm calcium. The activity of the released LTD4-dipeptidase was modulated by various metal ions and other compounds. The addition of Mn2+ Co2+, and Zn2+ (final concentration 1 mm) enhanced the LTD4-dipeptidase activity, while Cu2+ led to a complete inhibition. In the absence of exogenoas calcium EDTA inhibited LTD4-dipeptidase. Calcium up to a concentration of 5 and 10mm decreased the dipeptidase activity. The LTD4-dipeptidase is not affected by bestatin, leupeptin. or N-ethyl-maleinimide (NEM). The Km of LTD4-dipeptidase for LTD4 was 0.95±0.2μm and vmax was 737.5±112.5 pmol/min × mg protein (n = 3±SEM). The highest LTD4dipeptidase activity was obtained at physiological pH values. LTD4-dipeptidase activity can also be released from other cell types, but the enzyme activity from human PMN exceeded that of other cells (e.g. human lymphocytes/monocytes and basophils (LMB) and human lung cell suspension).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1987.tb01076.x
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  • 6
    Electronic Resource
    Electronic Resource
    Generation of Cell-Derived Factors Suppressing IgE Synthesis of Nippostrongylus brasiliensis-Infected Mice in Vitro (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Modulation of de novo IgE synthesis in vitro was studied using the parasitic infection of mice with the nematode Nippostrongylus brasiliensis. Cell-derived factors were generated by stimulation of splenic and mesenteric lymph node cells of BALB/c mice with monoclonal IgE in vitro. High molecular weight (〉50,000) and low molecular weight (〈50,000) culture superna-tants were prepared. De novo IgE synthesis of BALB/c lymphocytes-obtained from N. brasiliensis-reinfected mice that secreted pronounced quantities of IgE in vitro-was markedly reduced by the addition of high molecular weight supernatants. A dose-dependent suppression of IgE synthesis was obtained, whereas IgG synthesis, viability, and cell proliferation were not inhibited. After fractionation of low molecular weight supernatants with IgE-Sepharose the glycine/HCl eluate fractions markedly inhibited the in vitro IgE synthesis. Low molecular weight factors which suppressed IgE synthesis without modulating IgG production were obtained from IgE high responder B6D2F1 normal mouse cells. Thus, our results demonstrate the generation of IgE-specific suppressor factors in vitro upon stimulation with IgE. The suppression of IgE synthesis by eluate fractions of low molecular weight supernatants absorbed with IgE-Sepharose suggest a potential role for IgE binding factors on de novo IgE synthesis in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb02168.x
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  • 7
    Electronic Resource
    Electronic Resource
    Neutrophils, leukotrienes and bacteria (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01707.x
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  • 8
    Electronic Resource
    Electronic Resource
    Propolis allergy (IV) Studies with further sensitizers from propolis and constituents common to propolis, poplar buds and balsam of Peru (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 26 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 26 different compounds have been investigated experimentally for their sensitizing capacity in guinea pigs. 19 of these occur in propolis as well as in poplar bud exudates, and 14 of them are also found in balsam of Peru. 4 caffeates and benzyl isoferulate were found to be strong Sensitizers. 7 compounds were moderate, and 13 compounds showed only weak sensitizing potency. Methyl cinnamate was negative. Patch tests in 11 propolis-sensitive patients once more revealed 3-methyi-2-butenyl caffeate and phenylethyl caffeate as the major sensitizers. In addition to the 8 compounds already known to occur in propolis as well as in balsam of Peru, we detected 5 further substances that both materials have in common. Among these, benzyl isoferulate is considered a noteworthy sensitizer. Coniferyl benzoate, which was shown to be a moderate sensitizer, is present in fresh samples of balsam of Peru, while in propolis it has been detected only once so far. The flavonoid aglycones occurring in poplar bud exudates, and hence also in propolis, are weak sensitizers which play only a minor role m propolis hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb00865.x
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  • 9
    Electronic Resource
    Electronic Resource
    Primin as the source of sea-urchin hypersensitivity? (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 17 (1987), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1987.tb01490.x
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  • 10
    Electronic Resource
    Electronic Resource
    Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.) (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 17 (1987), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Experimental and chemical investigations revealed that common ivy (Hedera helix susp. Helix) contains 3 compounds which are powerful irritants and moderate sensitizers. Only 2 of these constituents, falcarinol and didehydrofalcarinol, are present in the plant during the whole year. Besides Panax ginseng and Schefflera arboricala, this is the third species of the Araliaceae in which these polyacetylenic sensitizers have been found. Falcarinol and didehydrofalcarinol also occur in Hedera helix subsp. canariensis. 4 patients have been patch tested. Even in low concentrations (0.03%). the main allergen falcarinol elicited strong reactions in all of them. One of the authors became sensitized during the investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1987.tb02634.x
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