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  • 1990-1994  (1)
  • 1985-1989  (1)
  • Endocytotic processes  (1)
  • Neutrophil activating peptide (NAP-1/IL-8)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical studies on NAP-1/IL-8 in contact eczema and atopic dermatitis (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 82-85 
    Details
    ISSN: 1432-069X
    Keywords: Neutrophil activating peptide (NAP-1/IL-8) ; Contact eczema ; Atopic dermatitis ; Inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neutrophil activating peptide NAP-1/IL-8 has in the past been shown to be secreted by diverse cell-types involved in inflammatory processes. Furthermore, potent biological effects on both neutrophilic granulocytes and lymphocytes enforce its role in inflammation. Recently, immunohistochemical studies using monoclonal anti-NAP-1/IL-8 antibodies have been performed on dermal inflammatory conditions like psoriasis vulgaris. These have demonstrated epidermal IL-8 immunoreactivity in a pattern inversely related to the degree of inflammatory infiltration. Based on these results, in the present study biopsies from patients with contact eczema as well as atopic dermatitis were examined. The same patterns of immunoreactivity were found with either homogenous epidermal staining, focally negative staining or overall decreased or even absent staining. As in psoriasis, these patterns were related to the degree of inflammatory infiltration. These results prove NAP-1/IL-8 to be involved not only in psoriasis vulgaris, but more likely to be a marker of different inflammatory processes. Future work will have to examine the kinetics as well as stimuli causing these effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373374
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Transendothelial cell diapedesis of neutrophils in inflamed human skin (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 475-481 
    Details
    ISSN: 1432-069X
    Keywords: Cell diapedesis ; Polymorphonuclear leukocytes ; Cutaneous inflammation ; Interleukin ; Endocytotic processes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mode of extravasation of neutrophils (PMNs) in cutaneous inflammation was studied in sequential biopsy specimens taken from human skin. Inflammatory skin reactions were produced by intracutaneous injection of endogeneous mediators of inflammation — C5ades arg, LTB4, neutrophil-activating peptide (NAP) and interleukin-1 (IL-1). Within 30 min after injection neutrophils were observed in close contact with endothelial cells of postcapillary venules and, following cytoplasmic engulfment, the cells were found to be transported transcellulary through the endothelial layer. In a total of 20 biopsy specimens taken at various times, cell migration via interendothelial gaps was absent. Instead, the transcellular pathway appeared to be the first and foremost mode of diapedesis. During this migratory process PMNs lacked signs of degranulation and numerous electron-lucent vesicles and secondary lysosomes were found. In addition, coated pits present on leukocyte as well as endothelial-cell membranes were indicative of receptor-mediated endocytotic processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510083
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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