ISSN:
1432-1335
Keywords:
Ehrlich ascites tumor cells
;
DNA over-replication
;
Anaerobiosis
;
G2M phase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%–85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation under standard conditions: a significant proportion of cells with increased DNA (DNA content〉4C) emerged. Interruption of DNA synthesis by deprivation of oxygen may account for polyploidisation (over-replication) of DNA but other mechanisms must be taken into consideration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00396389
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