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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Activities of enzyme markers of subcellular organelles have been measured in brain tissue from subjects with Alzheimer-type dementia (ATD) and Huntington's disease (HD). Significant increases in the activity of the lysosomal enzyme β-glucuronidase were observed in both ATD temporal cortex and HD putamen. It is suggested that β-glucuronidase activity may be a useful biochemical indicator of cellular damage in the CNS. A significant reduction in neutral α-glucosidase activity was observed in ATD temporal cortex and HD putamen. This change may reflect an alteration in glycoconjugate processing and may relate to the susceptibility of neurones to the degenerative processes of ATD and HD.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 1 (1994), S. 4043-4049 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The collisional heating rate of a fully ionized plasma driven by a strong electromagnetic pump wave is re-examined both analytically and with two-dimensional particle-in-cell (PIC) simulations. The high frequency conductivity model of Dawson and Oberman [J. Dawson and C. Oberman, Phys. Fluids 5, 517(1962)] is extended for the case in which the quiver velocity vo=eE/mωo is much larger than the thermal velocity vth and its equivalence to the results of Silin [V. P. Silin, Sov. Phys. JETP 20, 1510 (1965)] is shown. The Dawson and Oberman model is reduced to two-dimensions for comparison with the PIC simulations. Excellent agreement between the theory and the simulations for vo/vth≤1 is obtained. However, when vo/vth(very-much-greater-than)1 and the excursion amplitude xo=eE/mω2o is larger than the Debye length λD, the simulations show enhancements in the collision frequency from the theory. A possible mechanism for this enhancement is provided. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 1 (1989), S. 1001-1010 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Acceleration of both electrons and ions to relativistic energy by large amplitude magnetosonic waves is investigated by use of numerical simulation. Nonlinear effects are shown to form the saturation mechanism and limit the amplitude below the level where a particle specie can undergo unlimited acceleration, which is expected theoretically. Spiky structures appear both in density and field waveforms that are characteristics of the relativistic regime. Both electrons and ions are strongly accelerated by Elx×Bz drift and Ety field, but their resonance features versus fields are strongly different. Around the trapping time, relativistic electron solitonlike wavelets are triggered from the main wave ramp; a few mechanisms are proposed for their interpretation. Both electrons and ions are strongly heated at the expense of the wave energy. This damping in association with the large space charge effects resulting from the spiky structures is the origin of some observed saturation level in the field energy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 5 (1993), S. 3148-3162 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The modulational instability and collapse of waves in the vicinity of the lower-hybrid resonance including both magnetosonic and lower-hybrid waves are investigated by analytical and numerical methods. The mechanism leading to the modulational instability is the nonlinear coupling of lower-hybrid waves with the much lower-frequency quasineutral density perturbations via the ponderomotive force. The result is a filamentation of the high-frequency field producing elongated, cigar-shaped nonlinear wave packets aligned along the magnetic field with the plasma expelled outside (cavities). The analytical self-similar solutions describing cavity collapse are obtained and compared with the results of numerical simulation for both two- and three-dimensional cavity geometries. It is shown that in three-dimensional solutions the transverse, with respect to the magnetic field, contraction remains prevailing. The possibility of ion acceleration as the result of the lower-hybrid collapse is discussed and detailed comparison is made with the observations of the phenomena in the auroral ionosphere.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 3203-3203 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 1767-1788 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Particle dynamics and field behavior associated with a perpendicular collisionless supercritical and viscous shock are investigated by use of numerical simulation. A one-dimensional, relativistic, fully electromagnetic and nonperiodic particle simulation code (for both electrons and ions) is used where self-consistent space-charge effects and induced effects are totally included. The principal field patterns of the shock (trailing wave train, ramp, and foot region) are studied in detail and are shown to have scale lengths mainly dictated by ion dynamics; the behavior of the corresponding plasma currents associated with the different field components is also presented. Ions are shown to suffer successive "acceleration–trapping–detrapping'' at the shock front, and locally in the trailing wave train of the downstream region through combined effects of the electrostatic and magnetic fields. While detrapped, the reflected ions describe very large Larmor orbits and cause a ring distribution; a large rapid nonstochastic ion heating results from this ion gyration. This heating (resistivity-free) is the main source of dissipation and is responsible for large field damping. Competitive effects such as particle stochasticity, particle trapping, wave damping, wave overtaking, and dispersion effects are shown to interact with each other and to affect the overall dissipation mechanism. Comparison with previous works is also discussed. Various Mach number situations are considered, leading to the definition of a transitory regime between subcritical and supercritical regimes and of a corresponding critical threshold of the electrostatic field. In contrast with the supercritical regime, the subcritical regime is characterized by a low density of trapped-reflected ions, a broad ion distribution function with a weak tail, and a weak adiabatic bulk ion heating.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 1110-1114 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electron and ion dynamics are investigated through particle simulation of a supercritical oblique collisionless shock. As θ deviates from 90°, ions are accelerated and trapped in the electrostatic wells and later become detrapped; this results in strong ion heating perpendicular to B0. Below a critical angle θte electrons are strongly energized along B0, and heated. A large parallel electron current builds up and induces new transverse electromagnetic components in the ramp of the shock. For weaker angles, ion heating vanishes below a second critical angle θti.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 30 (1987), S. 3237-3244 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The parametric dependence of the growth rate of the low-frequency hot-electron interchange mode is studied with a two-and-a-half-dimensional relativistic electromagnetic particle code that models the geometry of a bumpy torus. The simulation results are compared in detail with finite-Larmor-radius theory, as well as zero-Larmor-radius theory. For the long-wavelength modes, the growth rates measured in the simulations tend to agree with those predicted from zero-Larmor-radius theory. For short-wavelength modes, the stabilizing effects of finite Larmor radius are significant.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 29 (1986), S. 821-836 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The behavior of strong magnetosonic waves propagating perpendicular to a static field B0 is investigated within the frequency range ωci〈ω〈ωlh; ωci,ω, and ωlh are, respectively, the ion cyclotron, the pump wave, and the lower-hybrid frequencies. A one-dimensional, relativistic, fully electromagnetic, particle simulation code (for both electrons and ions) is used, where self-consistent effects are totally included. During the buildup phase, a longitudinal electric field develops and attains a nonlinear level which strongly distorts its shape so that many harmonics are produced. This is followed shortly by ion trapping, which simultaneously enhances the wave overtaking (the wave crests overtaking the wave troughs) and produced a strong wave damping. A very large ion acceleration accompanied by a strong heating (mainly nonstochastic) perpendicular to B0 results; the electrons exhibit only poor heating associated with their adiabatic compression. The dynamics of both particle species, the consequences of the wave–particle energy transfer and the particle viscosities, are studied in detail. Competitive and self-consistent effects such as space-charge effects, wave overtaking, ion trapping, and wave damping are investigated and compared with previous models; the mechanisms by which these various phenomena interact on each other are analyzed. Characteristics of nonstochastic and stochastic ion heating are also discussed. Our computations show that if sufficient intensity is reached, one is not constrained to use lower-hybrid waves or cyclotron harmonic waves to heat a plasma efficiently and that any frequency below ωlh can be used.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 1384-1389 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The plasma physics associated with intense electron and positron beams in high-energy colliders is discussed. The focusing and plasma oscillation of these beams are studied in the presence of an externally supplied plasma (a plasma lens) and in the self-consistent fields of the interpenetrating beams. A plasma lens can provide strong focusing of a beam by shielding the beam's radial space-charge electric field and allowing it to self-pinch in its self-generated azimuthal magnetic field. The focusing force of a plasma lens can be equivalent to quadrupole magnet strengths of the order of hundreds of MG/cm. Theoretical and computational work characterizing the aberrations and final spot sizes possible with plasma lenses is presented. Furthermore, when the e+ and e− beams overlap at the interaction point (i.e., collide), they behave (temporarily) as a two-component plasma. The self-pinching or disruption of one beam by another in the e+e− plasma is modeled analytically and with two-dimensional particle-in-cell simulations.
    Type of Medium: Electronic Resource
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