ISSN:
1435-1536
Keywords:
5-trifluoromethyluracil
;
Sodium poly-α,L-glutamate
;
Interaction
;
Viscosity
;
1-(2-tetrahydrofuryl)-5-fluorouracil
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The purpose of our research is to obtain an understanding of the binding mechanism and to the correlations in term of chemical structure and the potentiactive drug activity. The interaction of 5-trifluoromethyluracil (although 5-trifluoromethyluracil do not used as anticancer drug, the structure of the compound has similar structure with 5-fluorouracil) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. It is very interesting that the value ofδH
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01419829
Permalink
