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  • 1990-1994  (2)
  • 1980-1984  (3)
  • Polymer and Materials Science  (4)
  • NK1 antagonist  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological characterisation of NK1 receptor antagonist, [D-Trp7]sendide, on behaviour elicited by substance P in the mouse (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 350 (1994), S. 387-392 
    Details
    ISSN: 1432-1912
    Keywords: [D-Trp7]Sendide ; NK1 antagonist ; Intrathecal injection ; Scratching, biting and licking ; NK1 receptor binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An analogue of sendide, [DTrp7]sendide, was newly synthetized and evaluated as a putative NK1 receptor antagonist in a mouse behavioural test. Effects of [DTrp7]sendide on the scratching, biting and licking response induced by substance P (SP), neurokinin A (NK A) and neurokinin B (NK B) was studied after intrathecal injections. When administered simultaneously with SP, an endogenous agonist for NK1 receptors, [DTrp7]sendide inhibited the behavioural response to this tachykinin in a dose-dependent manner with ID50 value of 1 t.0 pmol/mouse. The behavioural response elicited by other NK1 receptor agonists, septide and physalaemin, was reduced significantly by a small dose (32.0 pmol) of [DTrp7]sendide. Large doses (nmol order) of [DTrp7]sendide were needed to reduce the characteristic behaviour of NK A, an NK2 agonist, NK B, an NK3 agonist and eledoisin, an NK2/NK3 agonist. The duration of the antagonistic effect of [DTrp7]sendide was relatively longer. In a [3H]labeled SP binding assay using mouse spinal cord membranes, [DTrp7]sendide potently displaced [3H] labeled SP binding with a Ki value of 0.023 ± 0.007 nM, which was approximately 140 and 9400 times more potent than that of unlabeled SP and CP-96,345, respectively. These findings suggest that [DTrp7]sendide interacts selectively with the NK1 receptor in the mouse spinal cord as assayed by the receptor binding and SP-induced behavioural tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178956
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetics and mechanism of emulsion polymerization initiated by oil-soluble initiators. II. Kinetic behavior of styrene emulsion polymerization initiated by 2,2′-azoisobutyronitrile (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 29 (1991), S. 987-994 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In order to clarify the general kinetic behavior of emulsion polymerization initiated by oilsoluble initiators, the emulsion polymerization of styrene initiated by 2,2′-azoisobutyronitrile was as a typical example, investigated thoroughly. The variations of the polymerization rate and the number of polymer particles produced with changes in emulsifier (sodium lauryl sulfate), initiator, and monomer concentrations initially charged and the reaction temperature were determined. It is shown from these experimental results that the kinetic behavior of this emulsion polymerization system is quite similar to that of styrene emulsion polymerization initiated by the water-soluble initiator, potassium persulfate despite the difference in the principal loci of radical production in both systems.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1991.080290705
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanical properties of the soft contact lens of poly(methyl methacrylate-N-vinylpyrrolidone) (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 557-566 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The mechanical properties of the hydrogel membrane of poly(methyl methacrylate-N-vinylpyrrolidone) were studied for the purpose of making soft contact lenses for extended wear. The dependence of tensile fracture energy, flexibility, and recovery from deformation on the water content and thickness of the hydrogel membrane was studied. Reducing the thickness of a lens was found to exert a more advantageous effect than increasing its water content on maximizing the tensile fracture energy under the condition of an adequate supply of oxygen to the cornea through the contact lens. As long as its water content is controlled between 63 and 78%, the contact lens made of poly(methyl methacrylate-N-vinylpyrrolidone) has the flexibility on the same order as that of conventional soft contact lenses of poly(2-hydroxyethyl methacrylate). The rate of recovery from deformation increases with water content, and the residual elongation is negligible in the range of water content over about 70%. It is concluded that practical requirements for use of these contact lenses, determined by these three mechanical properties, can be satisfied at the same time if the water content of the contact lens is adjusted at about 70%.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140503
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Head-to-head polymers. XV. A facile synthesis of 2,3-disubstituted succinates and butanediols-1,4 (1980)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 18 (1980), S. 1739-1758 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A synthetic approach that makes symmetrically 2,3-dialkyl-substituted succinates and compounds prepared from 2,3-dialkyl-substituted succinates easily available has been developed. Coupling of α-bromoalkanoic esters with a zinc/copper couple produced in about 40% yield 2,3-disubstituted succinates which were reduced with LiAlH4 to 2,3-disubstituted butanediols-1,4 in nearly quantitative yields. Some 2,3-disubstituted butanediols-1,4 were cyclodehydrated under reduced pressure with KHSO4 to 3,4-disubstituted tetrahydrofurans or acetylated and the diacetyl compounds pyrolyzed at 525°C to 2,3 disubstituted butadienes-1,3. The length of the alkyl chains of the 2,3-dialkylsuccinates and consequently the 2,3-dialkylbutanediols-1,4 ranged from C2 to C16. 2,3-Disubstituted butanediols-1,4, 2,3-disubstituted butadienes-1,3, and 3,4-disubstituted tetrahydrofurans are interesting monomers for polymerization experiments.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1980.170180609
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on suspension and emulsion. XLVII. Anomalous composite polymer emulsion particles with voids produced by seeded emulsion polymerization (1981)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 19 (1981), S. 143-147 
    Details
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1981.130190310
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    Paper (German National Licenses)
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