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  • 1
    Electronic Resource
    Electronic Resource
    Presynaptic modulation of dopamine-induced locomotor activity by oxotremorine in nucleus accumbens of the rat (1982)
    Springer
    Journal of neural transmission 54 (1982), S. 137-143 
    Details
    ISSN: 1435-1463
    Keywords: Nucleus accumbens ; dopamine-induced locomotor activity ; oxotremorine ; presynaptic receptors ; 6-hydroxydopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Behavioural studies were carried out to determine whether central cholinergic mechanisms regulate dopaminergic activity by presynaptic mechanisms as suggested by recentin vitro studies. Bilateral injections of a muscarinic receptor agonist, oxotremorine (4μg), into the nucleus accumbens were found to enhance dopamine-induced locomotor activity. In rats deprived of presynaptic terminals by pretreatment with intraaccumbens injections of 6-hydroxydopamine, oxotremorine did not enhance dopamine-induced locomotor activity but on the contrary produced a marked reduction of locomotor activity. Although dopamine induced locomotor activity could occur in 6-hydroxydopamine treated animals, the muscarinic regulation was dependent on the presence of the intact dopamine terminal and hence a presynaptic receptor may be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01254923
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Feeding stimulated by very low doses of d-amphetamine administered systemically or by microinjection into the striatum (1982)
    Springer
    Psychopharmacology 78 (1982), S. 336-341 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Feeding ; Locomotion ; Stereotypy ; Striatum ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of d-amphetamine over a wide range of doses (0.125–4.0 mg/kg IP) on rat unconditioned behaviour were examined in the presence of food and water (experiment 1), in their absence (experiment 2) and after microinjection (2.0 μg in 0.5 μl) directly into the striatum (experiment 3). In experiment 1 very low doses (0.125 and 0.25 mg/kg) stimulated the intake of food, but not water, and higher doses produced locomotor hyperactivity, rearing, stereotyped sniffing and anorexia. In experiment 2 all doses, including very low doses (0.125 and 0.25 mg/kg), significantly potentiated locomotor activity. In experiment 3, microinjection into the corpus striatum elicited substantial feeding, but not drinking, locomotor activity or stereotyped behaviour. The results suggest that a single graded facilitative mechanism underlies the effects on food intake and other behavioural effects of amphetamine, as implied by a general hypothesis of amphetamine action proposed in the literature, and that these effects may to a large extent by mediated by forebrain dopamine systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433737
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of intracerebroventricular and systemic injections of caerulein, a CCK analogue, on electrical self-stimulation and its interaction with the CCKA receptor antagonist, L-364,718 (MK-329) (1990)
    Springer
    Psychopharmacology 101 (1990), S. 384-389 
    Details
    ISSN: 1432-2072
    Keywords: Caerulein ; Cholecystokinin ; L-364,718 ; CCKA receptors ; Self-stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Systemic administration of caerulein (10–100 µg/kg SC), a potent analogue of cholecystokinin, caused a profound dose-related depression of variable-interval self-stimulation, followed by progressive recovery within 60 min. Intracerebroventricular injection of caerulein (3–1000 ng) was not more effective than systemic injection, while injections into the nucleus accumbens (3–100 ng bilaterally) were without detectable effect. Systemic injections of L-364,718 (70–700 µg/kg IP), a specific competitive antagonist of CCKA (“peripheral-type”) receptors, had no effect on self-stimulation when given alone. When given in combination with caerulein, L-364,718 (200 µg/kg IP) significantly reduced the inhibitory effect of caerulein (30 µg/kg SC); however, this dose, and higher doses of L-364,718, failed to confer complete protection. It is concluded that self-stimulation performance may be subject to modulation by CCK receptors distributed predominantly in the peripheral nervous system and that some but not all of these receptors are CCKA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244058
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission (1993)
    Springer
    Journal of neural transmission 91 (1993), S. 1-11 
    Details
    ISSN: 1435-1463
    Keywords: d-Amphetamine ; dopamine ; nicotine ; ondansetron ; 5-HT3 receptor ; self-stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 5-HT3 receptors are abundant in central dopamine (DA) terminal areas. They do not affect basal DA turnover but appear to modulate DA release by e.g. morphine and nicotine. The interpretation of these findings is uncertain, and it is unclear whether 5-HT3 receptors also influence the activity of compounds such as amphetamine and cocaine, which act more directly on the DA synapse. Variable-interval (VI), threshold-current hypothalamic self-stimulation can provide a continuous index of central dopaminergic activity, but is relatively insensitive to changes in 5-HT and thus offers a means of investigating this question. In the present study, a selective 5-HT3 receptor antagonist, ondansetron (GR 38032F) (1.0 to 1000 μg/kg sc), had no effect on VI self-stimulation, nor did a 100 μg/kg dose affect facilitation of responding byd-amphetamine (500 jig/kg ip). Ondansetron (100 μg/kg) reduced the initial depression of self-stimulation by high-dose nicotine (400 μg/kg), but not the ensuing facilitation. Similar results were obtained in rats “sensitized” to nicotine by prior chronic exposure. These results support the proposal that 5-HT3 receptors, normally quiescent under basal conditions, mediate the excitatory effect of compounds acting upstream from the DA neuron, such as nicotine, but do not affect the dopaminergic synapse directly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244914
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward (1991)
    Springer
    Journal of neural transmission 83 (1991), S. 139-148 
    Details
    ISSN: 1435-1463
    Keywords: Buspirone ; dopamine ; feeding ; presynaptic receptor ; self-stimulation ; 5HT1A receptor ; 8-OH-DPAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two specific 5-HT1A agonists, 8-OH-DPAT (0–300 Μg/kg), and buspirone (0–3.0 mg/kg), were tested on variable-interval, threshold-current self-stimulation of rat lateral hypothalamus. Buspirone produced a prolonged monotonic depression of responding, whereas the effects of 8-OH-DPAT were biphasic: 3.0 Μg/kg produced a sustained enhancement of responding while higher doses (100–300 Μg/kg) produced a relatively short-lasting depression. This biphasic pattern parallels previously reported effects of 8-OH-DPAT on food intake and on various other behaviours. Threshold-current self-stimulation is highly sensitive to alterations in dopaminergic transmission but relatively insensitive to changes in 5-HT. Thus the facilitatory effect of low-dose 8-OH-DPAT seems most plausibly interpreted in terms of enhanced dopaminergic transmission. This could be brought about by 5HT1A autoreceptor-mediated inhibition of 5-HT release and consequent disinhibition of dopaminergic transmission. Depression of self-stimulation by higher doses of 8-OH-DPAT may reflect the activity of 8-OH-DPAT at postsynaptic 5-HT receptors, with consequent inhibition of DA transmission. Suppression of responding after buspirone at all doses tested may reflect the action of this compound as a partial agonist at postsynaptic 5-HT receptors, and/or its effects on other systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244460
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    Paper (German National Licenses)
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