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  • 1990-1994  (1)
  • 1980-1984  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Retention of topical liposomal formulations on the cornea (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 713-715 
    Details
    ISSN: 1420-9071
    Keywords: Rabbit cornea ; retention ; liposomes ; drug delivery ; ophthalmic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 μl drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery, liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939943
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential sensitivity of the two phases of ear artery contraction to intimal and adventitial norepinephrine (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 268-269 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The biphasic contraction of the rabbit ear artery to norepinephrine (NE) was investigated in the normal (adventitial stimulation) and the everted (intimal stimulation) segment of ear artery. The 2nd phase response showed an intimal ED50 of 8.2×10−8 M which was significantly (p〈0.05) lower than the adventitial ED50 of 42.6×10−8 M. This difference was abolished by inhibition of neuronal and extraneuronal uptake for NE. The 1st phase response also showed an ED50 for the intimal stimulation (6.9×10−8 M) which was significantly (p〈0.05) lower than adventitial (65.5×10−8 M). This difference was reduced but not abolished by NE uptake inhibition. This suggsets that some feature of the adrenergic neuroeffector apparatus is asymmetrically arranged to favor fast responses to blood borne NE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991648
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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