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  • 1
    Electronic Resource
    Electronic Resource
    Cerebrovascular autoregulation is resistant to calcium channel blockade with nimodipine (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 305-306 
    Details
    ISSN: 1420-9071
    Keywords: Baboon ; 133xenon ; cerebral blood flow ; cerebrovascular resistance ; autoregulation ; nimodipine ; calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In normal baboons cerebrovascular resistance changed along with blood pressure to maintain blood flow constant. This ‘autoregulation’ was not significantly altered in animals treated with a dose of the calcium channel blocker nimodipine causing selective cerebral vasodilation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951818
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1173-1174 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Jaundiced plasma and plasma from hyperlipidaemic patients was perfused into an isolated artery or kidney preparation. The responses of the artery to doses of noradrenaline when Krebs solution was perfused were compared to the responses when the plasmas were perfused. It was found that both jaundiced and hyperlipidaemic plasmas potentiated the effects of noradrenaline on the isolated arteries and kidneys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326776
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Differential sensitivity of the two phases of ear artery contraction to intimal and adventitial norepinephrine (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 268-269 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The biphasic contraction of the rabbit ear artery to norepinephrine (NE) was investigated in the normal (adventitial stimulation) and the everted (intimal stimulation) segment of ear artery. The 2nd phase response showed an intimal ED50 of 8.2×10−8 M which was significantly (p〈0.05) lower than the adventitial ED50 of 42.6×10−8 M. This difference was abolished by inhibition of neuronal and extraneuronal uptake for NE. The 1st phase response also showed an ED50 for the intimal stimulation (6.9×10−8 M) which was significantly (p〈0.05) lower than adventitial (65.5×10−8 M). This difference was reduced but not abolished by NE uptake inhibition. This suggsets that some feature of the adrenergic neuroeffector apparatus is asymmetrically arranged to favor fast responses to blood borne NE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991648
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Retention of topical liposomal formulations on the cornea (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 713-715 
    Details
    ISSN: 1420-9071
    Keywords: Rabbit cornea ; retention ; liposomes ; drug delivery ; ophthalmic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 μl drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery, liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939943
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    Paper (German National Licenses)
    Fulltext
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