ISSN:
1420-9071
Keywords:
Rabbit cornea
;
retention
;
liposomes
;
drug delivery
;
ophthalmic drugs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 μl drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery, liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01939943
Permalink
