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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms in acute septic cardiomyopathy: Evidence from isolated myocytes (1991)
    Springer
    Basic research in cardiology 86 (1991), S. 411-421 
    Details
    ISSN: 1435-1803
    Keywords: heart musclecells ; sepsis ; tumor necrosisfactor ; Pseudomonas exotoxin A ; β-adrenoceptor/G protein/adenylate cyclasesystem ; cardiodepressant factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although often not considered, the heart is one of the targets of multiple organ failure in sepsis and septic shock, with myocardial depression being a prominent component of this “acute septic cardiomyopathy”. Hypotheses concerning the etiology of this depression are increasingly elucidated on a cellular level, including dysfunction of the β-adrenoceptor/G protein/adenylate cyclase system, calcium channel blockade by cardiodepressant factor, contractile impairment by activated leucocytes, as well as inhibition of protein synthesis by Pseudomonas exotoxin A. In the search for “mechanisms of myocardial depression in sepsis”, isolated cardiomyocytes may play a role as research tools with respect to: a) discrimination between direct and indirect cardiodepressant effects; b) identifying not only the acute, but also chronic toxin- and mediator-induced cardiodepression; c) clarification of the mechanism of action of cardiodepressant bacterial toxins and sepsis mediators; d) establishment of in vitro models of leucocyte-mediated cardiodepressann in sepsis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190709
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Red cell count dependence of whole blood granulocyte luminescence (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 163-164 
    Details
    ISSN: 1432-1440
    Keywords: Luminescence ; Blood bactericidal activity ; Phagocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate phagocytosis of granulocyte, chemiluminescence (CL) — measurements were done in whole blood specimen. By this method much less variation (22% versus 84%) could be achieved in the whole blood specimen compared with isolated granulocytes. The quenching of CL by erythrocytes, which is dependent on the quotient erythrocytes/granulocytes, could be significantly reduced by dilution (1:5,000). Optimized reaction conditions were selected (approx. 5 × more sensitive then previous protocols) to evaluate the phagocytic activity of the few remaining granulocytes (approx. 2,000/ml) with routine luminometers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486371
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Decalcified and undecalcified cancellous bone block implants do not heal diaphyseal defects in dogs (1991)
    Springer
    Archives of orthopaedic and trauma surgery 111 (1991), S. 47-50 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a previous study it has been shown that granulae of decalcified bone matrix do not induce bony healing of 8-week-old mid-diaphyseal defects in dogs. The aim of this study was to test whether osteoinduction combined with the osteoconductive mechanisms provided by the natural structure of cancellous bone blocks would yield better results. A 30-mm-long diaphyseal defect of the left ulna was created in eight adult mongrel dogs and the bone was stabilized with a plate. A Silastic spacer was inserted in the defect for 8 weeks, followed by implantation of frozen undecalcified or decalcified allogeneic cancellous bone blocks for 16 weeks. Healing was analyzed using morphologic methods. At 16 weeks after implantation all grafts had been resorbed. In the decalcified group one defect healed, while none in the other group did so. The implant material was bioassayed in nude rats for osteoinductivity, which was found to be low in decalcified matrix and not detectable in undecalcified bone. Conclusion: Allogeneic cancellous bone blocks, demineralized or not, have no osteoinductive capacity and no osteoconductive function that promotes healing of mid-diaphyseal bone defects in dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390194
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral nerve repair with nerve growth factor and fibrin matrix (1994)
    Springer
    European journal of plastic surgery 17 (1994), S. 228-232 
    Details
    ISSN: 1435-0130
    Keywords: Nerve ; Regeneration Rat ; Growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A fibrin sealant matrix (FS) with or without a nerve growth factor (NGF) has been used to improve the recovery of severed peripheral nerves, and these have been compared with the results of using only the standard epineural suture (SUT). Regeneration in the early phase (up to 6 days) was measured by the pinch test. The functional recovery process (up to 12 weeks) was evaluated by serial gait track analysis. Longitudinal sections of the nerve specimens were submitted to immunohistochemical staining with monoclonal antibody against neurofilament. In addition, the release of the NGF from the NGF-FS matrix in vitro was investigated by ELISA. The regeneration of the leading sensory fibers was significantly faster in both FS groups (with and without NGF) than in the SUT group at 3 and 4 days postoperatively. The behavioural data expressed by the sciatic function index (SFI) and the toe spreading index (TSI) indicated significant improvement in NGF-FS group at the 9th week postoperatively (p〈0.05). Histologically, good and excellent outgrowth of neurites was encountered in both the NGF-FS and FS groups, while most of the results from SUT group were poor to satisfactory. In vitro, a peak of NGF release was seen within 18 h; afterwards, release remained slow for two weeks. It has been concluded that local application of a combination of FS and NGF may be useful for neuritic regeneration and subsequent functional recovery; the fibrin matrix itself may be beneficial for neuritic sprouting in the early phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208835
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Methodological approach to the characterization of diacylphosphatidyl cholines in rabbit lung lavage fluid by fast-atom bombardment mass spectrometryDedicated to Prof. J. F. K. Huber on the occasion of his 65th birthday. (1990)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 19-23 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Strong evidence exists that the distribution of phospholipids in the lung is a function of the degree of adult respiratory distress syndrome. The capabilities of positive-ion fast-atom bombardment (FAB) mass spectrometry for the determination of the relative distribution of intact diacylphosphatidylcholine species in lung lavage fluid were investigated. Two different FAB matrices and two different isolation/purification procedures - extraction/thin layer chromatography - high performance liquid chromatography (TLC-HPLC) - have been evaluated. In addition the relative fatty acid composition of the diacylphosphatidylcholines was determined by negative-ion FAB mass spectrometry using the [RCOO]- fragment ion. These results were compared with those obtained by gas chromatographic determination of the fatty acid methylesters.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290040107
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    Paper (German National Licenses)
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