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  • 1990-1994  (3)
  • 1975-1979  (1)
  • 1955-1959
  • Cold receptor  (2)
  • Gene expression  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Discharge pattern analysis suggests existence of a low-threshold calcium channel in cold receptors (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 47-50 
    Details
    ISSN: 1420-9071
    Keywords: Cold receptor ; periodic discharge pattern ; transducer process ; low-threshold calcium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The regular periodic activity patterns of mammalian cold receptors have been quantitatively studied. Analysis of the timing of either single impulses or impulse groups demonstrated that the periodic receptor process is maintained independently of impulse generation and continues to operate under conditions when afferent impulses are not initiated. These results imply that the underlying conductances must be operational at threshold potentials related to impulse generation. In addition to temperature, the periodic process is considerably sensitive to calcium, which affects mainly the probability of impulse generation during each cycle. Reduction of external calcium and application of calcium entry blockers with relative selectivity for low-threshold calcium channels are similarly effective in modulating cold receptor activity. The data imply the existence of a low-threshold calcium conductance at the sensory terminal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041249
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The ADP/ATP translocator from potato has a long amino-terminal extension (1991)
    Springer
    Current genetics 20 (1991), S. 405-410 
    Details
    ISSN: 1432-0983
    Keywords: ADP/ATP translocator ; Mitochondria ; Presequence ; Gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ADP/ATP translocator is an abundant protein of the mitochondrial inner membrane, which in fungi and mammals is synthesized without a presequence. Here we report that the translocator from potato has an amino-terminal extension which may function in mitochondrial targeting. Several cDNA clones encoding the nucleotide sequence of the ADP/ATP translocator have been isolated from potato leaf and tuber cDNA libraries constructed in lambda phages. Only one class of cDNA clones was found but possibly different translocator genes are expressed in other tissues. High levels of transcripts for the translocator are found in all tissues analysed. Sequence determination of the complete insert of one of the clones reveals a long open reading frame of 1158 bp encoding a protein of 386 amino acids corresponding to a calculated molecular weight of 42 kDa. In contrast, the ADP/ATP translocator proteins from fungi and mammals are significantly smaller. Comparison of the Neurospora translocator with the potato protein shows about 75% sequence homology, being confined to the region after amino acid 85 of the potato polypeptide. Antibodies directed against the fungal translocator recognize a protein of 30 kDa in the inner membrane of potato mitochondria, suggesting that the mature protein has a similar size as the translocators from fungi and mammals. Thus, the additional segment of the potato ADP/ATP translocator forms an amino-terminal extension which may be involved in the import of the protein into plant mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317069
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Parameters of the static burst discharge of lingual cold receptors in the cat (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 1-5 
    Details
    ISSN: 1432-2013
    Keywords: Cold receptor ; Burst parameters ; Lingual nerve ; Static discharge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thermal stimuli were applied to the upper surface of the tongue of the cat. The stimuli ranged from 40°C to 10°C and were changed in cold steps of 5°C, each temperature lasting 2 min. Afferent impulses of single specific cold fibers from the lingual nerve were analysed by a computer program. About 90% of the fibers showed bursts under static conditions. The bursts began as doublets at the temperature of maximal average frequency. This temperature varied from 40°C to 15°C in different fibers, the average being 30°C. The parameters burst period, burst duration, pause duration, intraburst interval and spikes per burst increased monotonically from 30°C to 15°C. The possible physiological significance of the burst pattern is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585897
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cytochrome c1 from potato: a protein with a presequence for targeting to the mitochondrial intermembrane space (1992)
    Springer
    Molecular genetics and genomics 231 (1992), S. 217-225 
    Details
    ISSN: 1617-4623
    Keywords: Cytochrome c 1 ; Solanum tuberosum ; Mitochondria ; Protein import ; Gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Here we report the primary structure of potato cytochrome c 1, a nuclear-encoded subunit of complex III. Using heterologous antibodies directed against cytochrome c 1 from yeast two types of clones were isolated from an expression library, suggesting that at least two different genes are present and expressed in the genome. Northern blot analysis reveals that slightly varying levels of cytochrome c 1 transcripts are present in all potato tissues analysed. A 1304 bp insert of one of the cDNA clones (pC13II) encodes the entire 320 amino acids of the precursor protein corresponding to a molecular weight of 35.2 kDa. As revealed by direct amino acid sequence determination of the cytochrome c 1 protein another cDNA clone (pC18I) encodes the major form of cytochrome c 1 present in potato tuber mitochondria. Western blots of subfractionated potato mitochondria show that the mature protein present in the membrane fraction is smaller than the pC13II encoded protein synthesized in Escherichia coli. The transient presequence of the protein is 77 amino acids long and has a bipartite polarity profile characteristic of presequences involved in targeting to the intermembrane space of fungal mitochondria. It consists of a positively charged NH2-terminal part which resembles “matrix targeting domains” and an adjacent hydrophobic region showing sequence similarities to “intramitochondrial sorting domains”. The amino-terminal region of potato cytochrome c 1 is the first presequence of a plant protein of the mitochondrial intermembrane space to be determined and may be useful in the study of intramitochondrial sorting in plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279794
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    Paper (German National Licenses)
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