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  • 1990-1994  (4)
  • 1975-1979
  • homosexuality  (2)
  • nuclear polyhedrosis virus  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A test of the maternal stress theory of human male homosexuality (1991)
    Springer
    Archives of sexual behavior 20 (1991), S. 277-293 
    Details
    ISSN: 1573-2800
    Keywords: maternal stress ; sexual orientation ; etiology ; homosexuality ; familiality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Both the neurohormonal theory of sexual orientation and previous research on humans and animals suggest that male homosexuality may arise from prenatal stress during the brain's sexual differentiation. Stress-proneness and retrospective reports of stress during pregnancy were obtained from mothers of male and female heterosexuals, bisexuals, and homosexuals. Each mother also rated pregnancy stress for a heterosexual sibling of the subject. For males, neither between-family nor within-family analyses revealed a maternal stress effect for either sexual orientation or childhood gender nonconformity. However, mothers of effeminate children reported more stress-proneness than other mothers. Male homosexuality nevertheless was strongly familial, suggesting a reconsideration of genetic and familial environmental mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541847
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maternally rated childhood gender nonconformity in homosexuals and heterosexuals (1993)
    Springer
    Archives of sexual behavior 22 (1993), S. 461-469 
    Details
    ISSN: 1573-2800
    Keywords: homosexuality ; gender nonconformity ; sexual orientation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Homosexual and heterosexual subjects provided self-ratings of childhood gender nonconformity. Additionally, their mother rated them on several adjectives describing childhood behavior, which included words related to gender nonconformity. Male homosexuals were remembered by their mothers as less masculine and more nonathletic. This finding did not appear to be due to a bias in mothers' memories. Though female homosexuals were recalled as more masculine than female heterosexuals, this appeared to reflect retrospective bias, as mothers who knew of their daughters' homosexuality were more likely to rate them as masculine. Both self-rated and maternally rated childhood gender nonconformity made independent contributions in predicting sexual orientation. Within the homosexual samples, maternal and self-ratings of subjects' childhood gender nonconformity failed to correlate significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01542559
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Modeling the population dynamics of baculovirus-infected insect cells: Optimizing infection strategies for enhanced recombinant protein yields (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 39 (1992), S. 432-441 
    Details
    ISSN: 0006-3592
    Keywords: nuclear polyhedrosis virus ; polyhedrin promoter ; population dynamics ; multiplicity of infection ; Poisson distribution ; baculovirus ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The insect cell-baculovirus model presented here is capable of simulating cell population dynamics, extracellular virion densities, and heterologous product titers in reasonable agreement with experimental data for a wide rang of multiplicities of infection (MOI) and times of infection. The model accounts for the infection of a single cell by multiple virions and the consequences on the time course of infection. The probability of infection by more than one virion was approximated using the Poisson distribution, which proved to be a refinement over second-order kinetics. The model tracks initiation and duration of important events in the progression of infected cell development (virus replication, recombinant protein synthesis, and cell lysis) for subpopulations delineated by the time and extent of their initial infection. The model suggests infection strategies, weighing the importance of MOI and infection time. Maximum product titers result from infection in the early exponential growth phase with low MOI.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260390409
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Production of a discrete, heterogeneous population of β-galactosidase polypeptides using baculovirus expression vectors (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 39 (1992), S. 932-944 
    Details
    ISSN: 0006-3592
    Keywords: Spodoptera frugiperda ; Autographa californica ; nuclear polyhedrosis virus ; polyhedrin promoter ; β-galactosidase ; heterogeneous polypeptides ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Gel electrophoresis analysis of immunoprecipitated β-galactosidase and polyhedrin-β-galactosidase expressed in Spodoptera frugiperda cells infected with recombinant Autograph californica nuclear polyhedrosis virus revealed the existence of a population of discrete β-galactosidase polypeptides. Several of the polypeptides observed in the fusion protein expression experiments exhibit a consistent pattern of slightly greater molecular weight when compared to the nonfusion β-galactosidase that is compatible with the hypothesis that these fusion protein fragments retain the N-terminal polyhedrin residues. Pulse-chase experiments showed that overall β-galactosidase degradation occurred at a negligible rate compared to the synthesis rate at 96 h postinfection, yet the fragments are observed for short pulse times. Degradation of several different β-galactosidase polypeptides was observed 24 h postinfection. Ribonucleic acid hybridization analysis of lacZ transcripts shows significant heterogeneity that may result from premature transcription termination. Although a proteolytic origin cannot be excluded, the data assembled suggest that premature termination of transcription or translation is the likely cause for the heterogeneous population of immunoreactive peptides observed. Many discrete forms of β-galactosidase polypeptides were also observed in studies with Escherichia coli, indicating that production of these heterogeneous forms is not a consequence of heterologous expression of the enzyme.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260390908
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    Paper (German National Licenses)
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